Plasmids Shape the Current Prevalence of <i>tmexCD1-toprJ1</i> among Klebsiella pneumoniae in Food Production Chains

Tigecycline, the first member of the glycylcycline class of antibacterial agents, is frequently used to treat complicated infections caused by multidrug-resistant Gram-positive and Gram-negative bacteria. The emergence of a novel plasmid-mediated efflux pump, TmexCD1-ToprJ1, conferring resistance t...

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Autores principales: Kai Peng, Qian Wang, Yi Yin, Yan Li, Yuan Liu, Mianzhi Wang, ShangShang Qin, Zhiqiang Wang, Ruichao Li
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
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Acceso en línea:https://doaj.org/article/8c540d9016e643b49e3e13d817d5aa47
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Sumario:Tigecycline, the first member of the glycylcycline class of antibacterial agents, is frequently used to treat complicated infections caused by multidrug-resistant Gram-positive and Gram-negative bacteria. The emergence of a novel plasmid-mediated efflux pump, TmexCD1-ToprJ1, conferring resistance to multiple antimicrobials, including tigecycline, poses a huge risk to human health.