Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles

Abstract Failure to remove a retrievable inferior vena cava (IVC) filter can cause severe complications with high treatment costs. Polydioxanone (PPDO) has been shown to be a good candidate material for resorbable IVC filters. However, PPDO is radioluscent under conventional imaging modalities. Thus...

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Autores principales:	Li Tian, Patrick Lee, Burapol Singhana, Aaron Chen, Yang Qiao, Linfeng Lu, Jonathan O. Martinez, Ennio Tasciotti, Adam Melancon, Steven Huang, Mitch Eggers, Marites P. Melancon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c573427fbca4175927707ce07620ded
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spelling	oai:doaj.org-article:8c573427fbca4175927707ce07620ded2021-12-02T12:32:54ZRadiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles10.1038/s41598-017-02508-32045-2322https://doaj.org/article/8c573427fbca4175927707ce07620ded2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02508-3https://doaj.org/toc/2045-2322Abstract Failure to remove a retrievable inferior vena cava (IVC) filter can cause severe complications with high treatment costs. Polydioxanone (PPDO) has been shown to be a good candidate material for resorbable IVC filters. However, PPDO is radioluscent under conventional imaging modalities. Thus, the positioning and integrity of these PPDO filters cannot be monitored by computed tomography (CT) or x-ray. Here we report the development of radiopaque PPDO IVC filters based on gold nanoparticles (AuNPs). Commercially available PPDO sutures were infused with AuNPs. Scanning electron microscopy analysis confirmed the presence of AuNP on the surface of PPDO. Micro-CT and x-ray images of the AuNP-infused PPDO sutures showed significant signal enhancement compared to untreated PPDO sutures. Elemental analysis showed that gold loading exceeded 2000 ppm. Tensile strength and in vitro cytotoxicity showed no significant difference between AuNP-infused and untreated PPDO. In a 10-week stability study, neither the gold content nor the radiopacity of the infused PPDO sutures significantly changed in the first 6 weeks. The increased attenuation of AuNP-infused PPDO sutures indicates their major advantage as a radiopaque resorbable filter material, as the radiopacity allows monitoring of the position and integrity of the filter, thereby increasing its safety and efficacy.Li TianPatrick LeeBurapol SinghanaAaron ChenYang QiaoLinfeng LuJonathan O. MartinezEnnio TasciottiAdam MelanconSteven HuangMitch EggersMarites P. MelanconNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Tian Patrick Lee Burapol Singhana Aaron Chen Yang Qiao Linfeng Lu Jonathan O. Martinez Ennio Tasciotti Adam Melancon Steven Huang Mitch Eggers Marites P. Melancon Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles
description	Abstract Failure to remove a retrievable inferior vena cava (IVC) filter can cause severe complications with high treatment costs. Polydioxanone (PPDO) has been shown to be a good candidate material for resorbable IVC filters. However, PPDO is radioluscent under conventional imaging modalities. Thus, the positioning and integrity of these PPDO filters cannot be monitored by computed tomography (CT) or x-ray. Here we report the development of radiopaque PPDO IVC filters based on gold nanoparticles (AuNPs). Commercially available PPDO sutures were infused with AuNPs. Scanning electron microscopy analysis confirmed the presence of AuNP on the surface of PPDO. Micro-CT and x-ray images of the AuNP-infused PPDO sutures showed significant signal enhancement compared to untreated PPDO sutures. Elemental analysis showed that gold loading exceeded 2000 ppm. Tensile strength and in vitro cytotoxicity showed no significant difference between AuNP-infused and untreated PPDO. In a 10-week stability study, neither the gold content nor the radiopacity of the infused PPDO sutures significantly changed in the first 6 weeks. The increased attenuation of AuNP-infused PPDO sutures indicates their major advantage as a radiopaque resorbable filter material, as the radiopacity allows monitoring of the position and integrity of the filter, thereby increasing its safety and efficacy.
format	article
author	Li Tian Patrick Lee Burapol Singhana Aaron Chen Yang Qiao Linfeng Lu Jonathan O. Martinez Ennio Tasciotti Adam Melancon Steven Huang Mitch Eggers Marites P. Melancon
author_facet	Li Tian Patrick Lee Burapol Singhana Aaron Chen Yang Qiao Linfeng Lu Jonathan O. Martinez Ennio Tasciotti Adam Melancon Steven Huang Mitch Eggers Marites P. Melancon
author_sort	Li Tian
title	Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles
title_short	Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles
title_full	Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles
title_fullStr	Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles
title_full_unstemmed	Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles
title_sort	radiopaque resorbable inferior vena cava filter infused with gold nanoparticles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8c573427fbca4175927707ce07620ded
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Radiopaque Resorbable Inferior Vena Cava Filter Infused with Gold Nanoparticles

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