Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment

Zhen Zhang,1 Hanqing Qian,2 Mi Yang,2 Rutian Li,2 Jing Hu,1 Li Li,1 Lixia Yu,2 Baorui Liu,1,2 Xiaoping Qian1,2 1Comprehensive Cancer Center, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, 2Comprehensive C...

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Autores principales:	Zhang Z, Qian HQ, Yang M, Li RT, Hu J, Li L, Yu LX, Liu BR, Qian XP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Gambogic acid Nanocarriers RBCm-GA/PLGA nanoparticles Colorectal cancer. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8c598308327846c5be005c9d62a40215
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spelling	oai:doaj.org-article:8c598308327846c5be005c9d62a402152021-12-02T00:39:21ZGambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment1178-2013https://doaj.org/article/8c598308327846c5be005c9d62a402152017-02-01T00:00:00Zhttps://www.dovepress.com/gambogic-acid-loaded-biomimetic-nanoparticles-in-colorectal-cancer-tre-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zhen Zhang,1 Hanqing Qian,2 Mi Yang,2 Rutian Li,2 Jing Hu,1 Li Li,1 Lixia Yu,2 Baorui Liu,1,2 Xiaoping Qian1,2 1Comprehensive Cancer Center, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, 2Comprehensive Cancer Center, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute, Nanjing University, Nanjing, China Abstract: Gambogic acid (GA) is expected to be a potential new antitumor drug, but its poor aqueous solubility and inevitable side effects limit its clinical application. Despite these inherent defects, various nanocarriers can be used to promote the solubility and tumor targeting of GA, improving antitumor efficiency. In addition, a cell membrane-coated nanoparticle platform that was reported recently, unites the customizability and flexibility of a synthetic copolymer, as well as the functionality and complexity of natural membrane, and is a new synthetic biomimetic nanocarrier with improved stability and biocompatibility. Here, we combined poly(lactic-co-glycolic acid) (PLGA) with red blood-cell membrane (RBCm), and evaluated whether GA-loaded RBCm nanoparticles can retain and improve the antitumor efficacy of GA with relatively lower toxicity in colorectal cancer treatment compared with free GA. We also confirmed the stability, biocompatibility, passive targeting, and few side effects of RBCm-GA/PLGA nanoparticles. We expect to provide a new drug carrier in the treatment of colorectal cancer, which has strong clinical application prospects. In addition, the potential antitumor drug GA and other similar drugs could achieve broader clinical applications via this biomimetic nanocarrier. Keywords: gambogic acid, nanocarriers, RBCm-GA/PLGA nanoparticles, colorectal cancerZhang ZQian HQYang MLi RTHu JLi LYu LXLiu BRQian XPDove Medical PressarticleGambogic acidNanocarriersRBCm-GA/PLGA nanoparticlesColorectal cancer.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1593-1605 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gambogic acid Nanocarriers RBCm-GA/PLGA nanoparticles Colorectal cancer. Medicine (General) R5-920
spellingShingle	Gambogic acid Nanocarriers RBCm-GA/PLGA nanoparticles Colorectal cancer. Medicine (General) R5-920 Zhang Z Qian HQ Yang M Li RT Hu J Li L Yu LX Liu BR Qian XP Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
description	Zhen Zhang,1 Hanqing Qian,2 Mi Yang,2 Rutian Li,2 Jing Hu,1 Li Li,1 Lixia Yu,2 Baorui Liu,1,2 Xiaoping Qian1,2 1Comprehensive Cancer Center, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, 2Comprehensive Cancer Center, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute, Nanjing University, Nanjing, China Abstract: Gambogic acid (GA) is expected to be a potential new antitumor drug, but its poor aqueous solubility and inevitable side effects limit its clinical application. Despite these inherent defects, various nanocarriers can be used to promote the solubility and tumor targeting of GA, improving antitumor efficiency. In addition, a cell membrane-coated nanoparticle platform that was reported recently, unites the customizability and flexibility of a synthetic copolymer, as well as the functionality and complexity of natural membrane, and is a new synthetic biomimetic nanocarrier with improved stability and biocompatibility. Here, we combined poly(lactic-co-glycolic acid) (PLGA) with red blood-cell membrane (RBCm), and evaluated whether GA-loaded RBCm nanoparticles can retain and improve the antitumor efficacy of GA with relatively lower toxicity in colorectal cancer treatment compared with free GA. We also confirmed the stability, biocompatibility, passive targeting, and few side effects of RBCm-GA/PLGA nanoparticles. We expect to provide a new drug carrier in the treatment of colorectal cancer, which has strong clinical application prospects. In addition, the potential antitumor drug GA and other similar drugs could achieve broader clinical applications via this biomimetic nanocarrier. Keywords: gambogic acid, nanocarriers, RBCm-GA/PLGA nanoparticles, colorectal cancer
format	article
author	Zhang Z Qian HQ Yang M Li RT Hu J Li L Yu LX Liu BR Qian XP
author_facet	Zhang Z Qian HQ Yang M Li RT Hu J Li L Yu LX Liu BR Qian XP
author_sort	Zhang Z
title	Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
title_short	Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
title_full	Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
title_fullStr	Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
title_full_unstemmed	Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
title_sort	gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/8c598308327846c5be005c9d62a40215
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Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment

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