Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.

The aim of this systematic review and meta-analysis was to identify a list of common, candidate genes associated with the three components of fitness, specifically cardiovascular fitness, muscular strength, and anaerobic power, and how these genes are associated with exercise response phenotype vari...

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Autores principales:	Henry C Chung, Don R Keiller, Justin D Roberts, Dan A Gordon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c5e2073d0234c78b9b54a66ddb5955a
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spelling	oai:doaj.org-article:8c5e2073d0234c78b9b54a66ddb5955a2021-12-02T20:13:41ZDo exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.1932-620310.1371/journal.pone.0249501https://doaj.org/article/8c5e2073d0234c78b9b54a66ddb5955a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0249501https://doaj.org/toc/1932-6203The aim of this systematic review and meta-analysis was to identify a list of common, candidate genes associated with the three components of fitness, specifically cardiovascular fitness, muscular strength, and anaerobic power, and how these genes are associated with exercise response phenotype variability, in previously untrained participants. A total of 3,969 potentially relevant papers were identified and processed for inclusion. After eligibility and study selection assessment, 24 studies were selected for meta-analysis, comprising a total of 3,012 participants (male n = 1,512; females n = 1,239; not stated n = 261; age 28 ± 9 years). Meta-Essentials spreadsheet 1.4 (Microsoft Excel) was used in creating the forest plots and meta-analysis. IBM SPSS statistics V24 was implemented for the statistical analyses and the alpha was set at p ≤ 0.05. 13 candidate genes and their associated alleles were identified, which were associated with the phenotypes of interest. Analysis of training group data showed significant differential phenotypic responses. Subgroup analysis showed; 44%, 72% and 10% of the response variance in aerobic, strength and power phenotypes, respectively, were explained by genetic influences. This analysis established that genetic variability explained a significant proportion of the adaptation differences across the three components of fitness in the participants post-training. The results also showed the importance of analysing and reporting specific gene alleles. Information obtained from these findings has the potential to inform and influence future exercise-related genes and training studies.Henry C ChungDon R KeillerJustin D RobertsDan A GordonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0249501 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Henry C Chung Don R Keiller Justin D Roberts Dan A Gordon Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.
description	The aim of this systematic review and meta-analysis was to identify a list of common, candidate genes associated with the three components of fitness, specifically cardiovascular fitness, muscular strength, and anaerobic power, and how these genes are associated with exercise response phenotype variability, in previously untrained participants. A total of 3,969 potentially relevant papers were identified and processed for inclusion. After eligibility and study selection assessment, 24 studies were selected for meta-analysis, comprising a total of 3,012 participants (male n = 1,512; females n = 1,239; not stated n = 261; age 28 ± 9 years). Meta-Essentials spreadsheet 1.4 (Microsoft Excel) was used in creating the forest plots and meta-analysis. IBM SPSS statistics V24 was implemented for the statistical analyses and the alpha was set at p ≤ 0.05. 13 candidate genes and their associated alleles were identified, which were associated with the phenotypes of interest. Analysis of training group data showed significant differential phenotypic responses. Subgroup analysis showed; 44%, 72% and 10% of the response variance in aerobic, strength and power phenotypes, respectively, were explained by genetic influences. This analysis established that genetic variability explained a significant proportion of the adaptation differences across the three components of fitness in the participants post-training. The results also showed the importance of analysing and reporting specific gene alleles. Information obtained from these findings has the potential to inform and influence future exercise-related genes and training studies.
format	article
author	Henry C Chung Don R Keiller Justin D Roberts Dan A Gordon
author_facet	Henry C Chung Don R Keiller Justin D Roberts Dan A Gordon
author_sort	Henry C Chung
title	Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.
title_short	Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.
title_full	Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.
title_fullStr	Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.
title_full_unstemmed	Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.
title_sort	do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8c5e2073d0234c78b9b54a66ddb5955a
work_keys_str_mv	AT henrycchung doexerciseassociatedgenesexplainphenotypicvarianceinthethreecomponentsoffitnessasystematicreviewmetaanalysis AT donrkeiller doexerciseassociatedgenesexplainphenotypicvarianceinthethreecomponentsoffitnessasystematicreviewmetaanalysis AT justindroberts doexerciseassociatedgenesexplainphenotypicvarianceinthethreecomponentsoffitnessasystematicreviewmetaanalysis AT danagordon doexerciseassociatedgenesexplainphenotypicvarianceinthethreecomponentsoffitnessasystematicreviewmetaanalysis
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Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.

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