The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain

The mechanisms underlying gene regulation and genome architecture remain poorly understood. Here, the authors investigate the role of chromatin remodelling enzyme Chd4 in granule neurons of the mouse cerebellum and find that conditional knockout of Chd4 preferentially activates enhancers and modulat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jared V. Goodman, Tomoko Yamada, Yue Yang, Lingchun Kong, Dennis Y. Wu, Guoyan Zhao, Harrison W. Gabel, Azad Bonni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c5f1f247923448eb79492786dde4b16
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8c5f1f247923448eb79492786dde4b16
record_format	dspace
spelling	oai:doaj.org-article:8c5f1f247923448eb79492786dde4b162021-12-02T15:23:19ZThe chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain10.1038/s41467-020-17065-z2041-1723https://doaj.org/article/8c5f1f247923448eb79492786dde4b162020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17065-zhttps://doaj.org/toc/2041-1723The mechanisms underlying gene regulation and genome architecture remain poorly understood. Here, the authors investigate the role of chromatin remodelling enzyme Chd4 in granule neurons of the mouse cerebellum and find that conditional knockout of Chd4 preferentially activates enhancers and modulates genome architecture at a genome-wide level.Jared V. GoodmanTomoko YamadaYue YangLingchun KongDennis Y. WuGuoyan ZhaoHarrison W. GabelAzad BonniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jared V. Goodman Tomoko Yamada Yue Yang Lingchun Kong Dennis Y. Wu Guoyan Zhao Harrison W. Gabel Azad Bonni The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
description	The mechanisms underlying gene regulation and genome architecture remain poorly understood. Here, the authors investigate the role of chromatin remodelling enzyme Chd4 in granule neurons of the mouse cerebellum and find that conditional knockout of Chd4 preferentially activates enhancers and modulates genome architecture at a genome-wide level.
format	article
author	Jared V. Goodman Tomoko Yamada Yue Yang Lingchun Kong Dennis Y. Wu Guoyan Zhao Harrison W. Gabel Azad Bonni
author_facet	Jared V. Goodman Tomoko Yamada Yue Yang Lingchun Kong Dennis Y. Wu Guoyan Zhao Harrison W. Gabel Azad Bonni
author_sort	Jared V. Goodman
title	The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
title_short	The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
title_full	The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
title_fullStr	The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
title_full_unstemmed	The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
title_sort	chromatin remodeling enzyme chd4 regulates genome architecture in the mouse brain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8c5f1f247923448eb79492786dde4b16
work_keys_str_mv	AT jaredvgoodman thechromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT tomokoyamada thechromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT yueyang thechromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT lingchunkong thechromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT dennisywu thechromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT guoyanzhao thechromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT harrisonwgabel thechromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT azadbonni thechromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT jaredvgoodman chromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT tomokoyamada chromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT yueyang chromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT lingchunkong chromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT dennisywu chromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT guoyanzhao chromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT harrisonwgabel chromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain AT azadbonni chromatinremodelingenzymechd4regulatesgenomearchitectureinthemousebrain
_version_	1718387277012402176

The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain

Ejemplares similares