The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
The mechanisms underlying gene regulation and genome architecture remain poorly understood. Here, the authors investigate the role of chromatin remodelling enzyme Chd4 in granule neurons of the mouse cerebellum and find that conditional knockout of Chd4 preferentially activates enhancers and modulat...
Guardado en:
Autores principales: | Jared V. Goodman, Tomoko Yamada, Yue Yang, Lingchun Kong, Dennis Y. Wu, Guoyan Zhao, Harrison W. Gabel, Azad Bonni |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/8c5f1f247923448eb79492786dde4b16 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum
por: Naveen C. Reddy, et al.
Publicado: (2021) -
The CHD6 chromatin remodeler is an oxidative DNA damage response factor
por: Shaun Moore, et al.
Publicado: (2019) -
CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.
por: Rebecca Casaday Potts, et al.
Publicado: (2011) -
The chromatin remodeler Chd1 supports MRX and Exo1 functions in resection of DNA double-strand breaks.
por: Marco Gnugnoli, et al.
Publicado: (2021) -
The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration
por: Mohi Ahmed, et al.
Publicado: (2021)