Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer—A Systematic Review

(1) Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common malignancies globally. An early diagnosis of this disease is crucial, and the detection of gene mutations in circulating tumour DNA (ctDNA) through a liquid biopsy is a promising non-invasive diagnostic method. T...

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Autores principales:	Markéta Hudečková, Vladimír Koucký, Jan Rottenberg, Břetislav Gál
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	head and neck cancer squamous cell carcinoma (HNSCC) circulating tumour DNA (ctDNA) diagnostic biomarker liquid biopsy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8c5f741182f74c14a2fe530c469d20be
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spelling	oai:doaj.org-article:8c5f741182f74c14a2fe530c469d20be2021-11-25T16:48:53ZGene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer—A Systematic Review10.3390/biomedicines91115482227-9059https://doaj.org/article/8c5f741182f74c14a2fe530c469d20be2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1548https://doaj.org/toc/2227-9059(1) Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common malignancies globally. An early diagnosis of this disease is crucial, and the detection of gene mutations in circulating tumour DNA (ctDNA) through a liquid biopsy is a promising non-invasive diagnostic method. This review aims to provide an overview of ctDNA mutations in HNSCC patients and discuss the potential use of this tool in diagnosis and prognosis. (2) Methods: A systematic search for articles published in the English language between January 2000 and April 2021 in the Medline and Scopus databases was conducted. (3) Results: A total of 10 studies published in nine publications were selected and analysed. Altogether, 390 samples were obtained from HNSCC patients, and 79 control samples were evaluated. The most often explored gene mutation in ctDNA was <i>TP53</i>. (4) Conclusions: The examination of a larger group of gene mutations and the use of a combination of multiple detection methods contribute to a higher detection rate of mutated ctDNA. More studies are necessary to verify these conclusions and to translate them into clinical practice.Markéta HudečkováVladimír KouckýJan RottenbergBřetislav GálMDPI AGarticlehead and neck cancer squamous cell carcinoma (HNSCC)circulating tumour DNA (ctDNA)diagnostic biomarkerliquid biopsyBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1548, p 1548 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	head and neck cancer squamous cell carcinoma (HNSCC) circulating tumour DNA (ctDNA) diagnostic biomarker liquid biopsy Biology (General) QH301-705.5
spellingShingle	head and neck cancer squamous cell carcinoma (HNSCC) circulating tumour DNA (ctDNA) diagnostic biomarker liquid biopsy Biology (General) QH301-705.5 Markéta Hudečková Vladimír Koucký Jan Rottenberg Břetislav Gál Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer—A Systematic Review
description	(1) Background: Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the most common malignancies globally. An early diagnosis of this disease is crucial, and the detection of gene mutations in circulating tumour DNA (ctDNA) through a liquid biopsy is a promising non-invasive diagnostic method. This review aims to provide an overview of ctDNA mutations in HNSCC patients and discuss the potential use of this tool in diagnosis and prognosis. (2) Methods: A systematic search for articles published in the English language between January 2000 and April 2021 in the Medline and Scopus databases was conducted. (3) Results: A total of 10 studies published in nine publications were selected and analysed. Altogether, 390 samples were obtained from HNSCC patients, and 79 control samples were evaluated. The most often explored gene mutation in ctDNA was <i>TP53</i>. (4) Conclusions: The examination of a larger group of gene mutations and the use of a combination of multiple detection methods contribute to a higher detection rate of mutated ctDNA. More studies are necessary to verify these conclusions and to translate them into clinical practice.
format	article
author	Markéta Hudečková Vladimír Koucký Jan Rottenberg Břetislav Gál
author_facet	Markéta Hudečková Vladimír Koucký Jan Rottenberg Břetislav Gál
author_sort	Markéta Hudečková
title	Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer—A Systematic Review
title_short	Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer—A Systematic Review
title_full	Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer—A Systematic Review
title_fullStr	Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer—A Systematic Review
title_full_unstemmed	Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer—A Systematic Review
title_sort	gene mutations in circulating tumour dna as a diagnostic and prognostic marker in head and neck cancer—a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8c5f741182f74c14a2fe530c469d20be
work_keys_str_mv	AT marketahudeckova genemutationsincirculatingtumourdnaasadiagnosticandprognosticmarkerinheadandneckcancerasystematicreview AT vladimirkoucky genemutationsincirculatingtumourdnaasadiagnosticandprognosticmarkerinheadandneckcancerasystematicreview AT janrottenberg genemutationsincirculatingtumourdnaasadiagnosticandprognosticmarkerinheadandneckcancerasystematicreview AT bretislavgal genemutationsincirculatingtumourdnaasadiagnosticandprognosticmarkerinheadandneckcancerasystematicreview
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Gene Mutations in Circulating Tumour DNA as a Diagnostic and Prognostic Marker in Head and Neck Cancer—A Systematic Review

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