Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy

Abstract Polychlorinated biphenyls (PCBs) are human carcinogens, based on sufficient evidence for melanoma and limited evidence for non-Hodgkin lymphoma and breast cancer. Few data are available for liver cancer, although PCBs cause it in rats and determined liver damage in poisoned people. We inves...

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Autores principales:	Francesco Donato, Marco Moneda, Nazario Portolani, Angelo Rossini, Sarah Molfino, Silvia Ministrini, Giovanni Battista Contessi, Silvia Pesenti, Giuseppe De Palma, Alice Gaia, Elena Zanardini, Claudio Vito Sileo, Michele Magoni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c61dfe805924fbd95fa80ee94bbfe21
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spelling	oai:doaj.org-article:8c61dfe805924fbd95fa80ee94bbfe212021-12-02T14:06:18ZPolychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy10.1038/s41598-021-82657-82045-2322https://doaj.org/article/8c61dfe805924fbd95fa80ee94bbfe212021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82657-8https://doaj.org/toc/2045-2322Abstract Polychlorinated biphenyls (PCBs) are human carcinogens, based on sufficient evidence for melanoma and limited evidence for non-Hodgkin lymphoma and breast cancer. Few data are available for liver cancer, although PCBs cause it in rats and determined liver damage in poisoned people. We investigated the association between PCB serum levels and hepatocellular carcinoma (HCC) with a case–control study in a PCB-polluted area in North Italy. We enrolled prospectively 102 HCC incident cases and 102 age and gender-matched hospital controls. Serum concentrations of 33 PCB congeners were determined by a gas chromatograph coupled to mass spectrometry. Of 102 HCC cases, 62 who had lost < 3 kg of body weight in past 3 years were included in the analysis (67.7% males, mean age 68 years). The odds ratio (OR) for HCC for 3rd compared to 1st tertile of PCB distribution was 1.76 (95% confidence interval 0.62–5.03) for total PCB, adjusting for socio-demographic variables and risk factors for HCC by logistic regression. For most PCB congeners, ORs > 1.5 or 2 were found, although the 95% CIs included the null value for almost all of them. This preliminary study suggests that PCBs might play a role in HCC development.Francesco DonatoMarco MonedaNazario PortolaniAngelo RossiniSarah MolfinoSilvia MinistriniGiovanni Battista ContessiSilvia PesentiGiuseppe De PalmaAlice GaiaElena ZanardiniClaudio Vito SileoMichele MagoniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francesco Donato Marco Moneda Nazario Portolani Angelo Rossini Sarah Molfino Silvia Ministrini Giovanni Battista Contessi Silvia Pesenti Giuseppe De Palma Alice Gaia Elena Zanardini Claudio Vito Sileo Michele Magoni Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
description	Abstract Polychlorinated biphenyls (PCBs) are human carcinogens, based on sufficient evidence for melanoma and limited evidence for non-Hodgkin lymphoma and breast cancer. Few data are available for liver cancer, although PCBs cause it in rats and determined liver damage in poisoned people. We investigated the association between PCB serum levels and hepatocellular carcinoma (HCC) with a case–control study in a PCB-polluted area in North Italy. We enrolled prospectively 102 HCC incident cases and 102 age and gender-matched hospital controls. Serum concentrations of 33 PCB congeners were determined by a gas chromatograph coupled to mass spectrometry. Of 102 HCC cases, 62 who had lost < 3 kg of body weight in past 3 years were included in the analysis (67.7% males, mean age 68 years). The odds ratio (OR) for HCC for 3rd compared to 1st tertile of PCB distribution was 1.76 (95% confidence interval 0.62–5.03) for total PCB, adjusting for socio-demographic variables and risk factors for HCC by logistic regression. For most PCB congeners, ORs > 1.5 or 2 were found, although the 95% CIs included the null value for almost all of them. This preliminary study suggests that PCBs might play a role in HCC development.
format	article
author	Francesco Donato Marco Moneda Nazario Portolani Angelo Rossini Sarah Molfino Silvia Ministrini Giovanni Battista Contessi Silvia Pesenti Giuseppe De Palma Alice Gaia Elena Zanardini Claudio Vito Sileo Michele Magoni
author_facet	Francesco Donato Marco Moneda Nazario Portolani Angelo Rossini Sarah Molfino Silvia Ministrini Giovanni Battista Contessi Silvia Pesenti Giuseppe De Palma Alice Gaia Elena Zanardini Claudio Vito Sileo Michele Magoni
author_sort	Francesco Donato
title	Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
title_short	Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
title_full	Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
title_fullStr	Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
title_full_unstemmed	Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
title_sort	polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in italy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8c61dfe805924fbd95fa80ee94bbfe21
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Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy

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