In vitro and in vivo studies of surface-structured implants for bone formation

Lu Xia,1,2 Bo Feng,1 Peizhi Wang,2 Siyang Ding,2 Zhiyuan Liu,1 Jie Zhou,1 Rong Yu11Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan; 2Research Institute of Stomatology, Nanjing Me...

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Autores principales:	Xia L, Feng B, Wang PZ, Ding SY, Liu ZY, Zhou J, Yu R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8c6354a2df5d46329a2ac09365fb3faf
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spelling	oai:doaj.org-article:8c6354a2df5d46329a2ac09365fb3faf2021-12-02T01:08:06ZIn vitro and in vivo studies of surface-structured implants for bone formation1176-91141178-2013https://doaj.org/article/8c6354a2df5d46329a2ac09365fb3faf2012-09-01T00:00:00Zhttp://www.dovepress.com/in-vitro-and-in-vivo-studies-of-surface-structured-implants-for-bone-f-a10963https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Lu Xia,1,2 Bo Feng,1 Peizhi Wang,2 Siyang Ding,2 Zhiyuan Liu,1 Jie Zhou,1 Rong Yu11Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan; 2Research Institute of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, ChinaBackground and methods: Micronanoscale topologies play an important role in implant osteointegration and determine the success of an implant. We investigated the effect of three different implant surface topologies on osteoblast response and bone regeneration. In this study, implants with nanotubes and micropores were used, and implants with flat surfaces were used as the control group.Results: Our in vitro studies showed that the nanostructured topologies improved the proliferation, differentiation, and development of the osteoblastic phenotype. Histological analysis further revealed that the nanotopology increased cell aggregation at the implant-tissue interfaces and enhanced bone-forming ability. Pushout testing indicated that the nanostructured topology greatly increased the bone-implant interfacial strength within 4 weeks of implantation.Conclusion: Nanotopography may improve regeneration of bone tissue and shows promise for dental implant applications.Keywords: osteoblast, osteointegration, titanium, nanostructure, microstructureXia LFeng BWang PZDing SYLiu ZYZhou JYu RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 4873-4881 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xia L Feng B Wang PZ Ding SY Liu ZY Zhou J Yu R In vitro and in vivo studies of surface-structured implants for bone formation
description	Lu Xia,1,2 Bo Feng,1 Peizhi Wang,2 Siyang Ding,2 Zhiyuan Liu,1 Jie Zhou,1 Rong Yu11Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan; 2Research Institute of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, ChinaBackground and methods: Micronanoscale topologies play an important role in implant osteointegration and determine the success of an implant. We investigated the effect of three different implant surface topologies on osteoblast response and bone regeneration. In this study, implants with nanotubes and micropores were used, and implants with flat surfaces were used as the control group.Results: Our in vitro studies showed that the nanostructured topologies improved the proliferation, differentiation, and development of the osteoblastic phenotype. Histological analysis further revealed that the nanotopology increased cell aggregation at the implant-tissue interfaces and enhanced bone-forming ability. Pushout testing indicated that the nanostructured topology greatly increased the bone-implant interfacial strength within 4 weeks of implantation.Conclusion: Nanotopography may improve regeneration of bone tissue and shows promise for dental implant applications.Keywords: osteoblast, osteointegration, titanium, nanostructure, microstructure
format	article
author	Xia L Feng B Wang PZ Ding SY Liu ZY Zhou J Yu R
author_facet	Xia L Feng B Wang PZ Ding SY Liu ZY Zhou J Yu R
author_sort	Xia L
title	In vitro and in vivo studies of surface-structured implants for bone formation
title_short	In vitro and in vivo studies of surface-structured implants for bone formation
title_full	In vitro and in vivo studies of surface-structured implants for bone formation
title_fullStr	In vitro and in vivo studies of surface-structured implants for bone formation
title_full_unstemmed	In vitro and in vivo studies of surface-structured implants for bone formation
title_sort	in vitro and in vivo studies of surface-structured implants for bone formation
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/8c6354a2df5d46329a2ac09365fb3faf
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In vitro and in vivo studies of surface-structured implants for bone formation

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