The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.

The generation of a diversity of photoreceptor (PR) subtypes with different spectral sensitivities is essential for color vision in animals. In the Drosophila eye, the Hippo pathway has been implicated in blue- and green-sensitive PR subtype fate specification. Specifically, Hippo pathway activation...

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Autores principales:	Qingliang Sang, Gang Wang, David B Morton, Hui Wu, Baotong Xie
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/8c65de35f2184309a08b07d3e4fde6b7
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spelling	oai:doaj.org-article:8c65de35f2184309a08b07d3e4fde6b72021-12-02T20:03:26ZThe ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.1553-73901553-740410.1371/journal.pgen.1009894https://doaj.org/article/8c65de35f2184309a08b07d3e4fde6b72021-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009894https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404The generation of a diversity of photoreceptor (PR) subtypes with different spectral sensitivities is essential for color vision in animals. In the Drosophila eye, the Hippo pathway has been implicated in blue- and green-sensitive PR subtype fate specification. Specifically, Hippo pathway activation promotes green-sensitive PR fate at the expense of blue-sensitive PRs. Here, using a sensitized triple heterozygote-based genetic screening approach, we report the identification of the single Drosophila zonula occludens-1 (ZO-1) protein Polychaetoid (Pyd) as a new regulator of the Hippo pathway during the blue- and green-sensitive PR subtype binary fate choice. We demonstrate that Pyd acts upstream of the core components and the upstream regulator Pez in the Hippo pathway. Furthermore, We found that Pyd represses the activity of Su(dx), a E3 ligase that negatively regulates Pez and can physically interact with Pyd, during PR subtype fate specification. Together, our results identify a new mechanism underlying the Hippo signaling pathway in post-mitotic neuronal fate specification.Qingliang SangGang WangDavid B MortonHui WuBaotong XiePublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 11, p e1009894 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Qingliang Sang Gang Wang David B Morton Hui Wu Baotong Xie The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.
description	The generation of a diversity of photoreceptor (PR) subtypes with different spectral sensitivities is essential for color vision in animals. In the Drosophila eye, the Hippo pathway has been implicated in blue- and green-sensitive PR subtype fate specification. Specifically, Hippo pathway activation promotes green-sensitive PR fate at the expense of blue-sensitive PRs. Here, using a sensitized triple heterozygote-based genetic screening approach, we report the identification of the single Drosophila zonula occludens-1 (ZO-1) protein Polychaetoid (Pyd) as a new regulator of the Hippo pathway during the blue- and green-sensitive PR subtype binary fate choice. We demonstrate that Pyd acts upstream of the core components and the upstream regulator Pez in the Hippo pathway. Furthermore, We found that Pyd represses the activity of Su(dx), a E3 ligase that negatively regulates Pez and can physically interact with Pyd, during PR subtype fate specification. Together, our results identify a new mechanism underlying the Hippo signaling pathway in post-mitotic neuronal fate specification.
format	article
author	Qingliang Sang Gang Wang David B Morton Hui Wu Baotong Xie
author_facet	Qingliang Sang Gang Wang David B Morton Hui Wu Baotong Xie
author_sort	Qingliang Sang
title	The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.
title_short	The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.
title_full	The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.
title_fullStr	The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.
title_full_unstemmed	The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.
title_sort	zo-1 protein polychaetoid as an upstream regulator of the hippo pathway in drosophila.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8c65de35f2184309a08b07d3e4fde6b7
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The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.

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