Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis

The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread.

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Autores principales:	Tamara Muliaditan, Jonathan Caron, Mary Okesola, James W. Opzoomer, Paris Kosti, Mirella Georgouli, Peter Gordon, Sharanpreet Lall, Desislava M. Kuzeva, Luisa Pedro, Jacqueline D. Shields, Cheryl E. Gillett, Sandra S. Diebold, Victoria Sanz-Moreno, Tony Ng, Esther Hoste, James N. Arnold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c66af37aaba412f826bf1e4aabd5fd7
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spelling	oai:doaj.org-article:8c66af37aaba412f826bf1e4aabd5fd72021-12-02T15:34:38ZMacrophages are exploited from an innate wound healing response to facilitate cancer metastasis10.1038/s41467-018-05346-72041-1723https://doaj.org/article/8c66af37aaba412f826bf1e4aabd5fd72018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05346-7https://doaj.org/toc/2041-1723The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread.Tamara MuliaditanJonathan CaronMary OkesolaJames W. OpzoomerParis KostiMirella GeorgouliPeter GordonSharanpreet LallDesislava M. KuzevaLuisa PedroJacqueline D. ShieldsCheryl E. GillettSandra S. DieboldVictoria Sanz-MorenoTony NgEsther HosteJames N. ArnoldNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tamara Muliaditan Jonathan Caron Mary Okesola James W. Opzoomer Paris Kosti Mirella Georgouli Peter Gordon Sharanpreet Lall Desislava M. Kuzeva Luisa Pedro Jacqueline D. Shields Cheryl E. Gillett Sandra S. Diebold Victoria Sanz-Moreno Tony Ng Esther Hoste James N. Arnold Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
description	The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread.
format	article
author	Tamara Muliaditan Jonathan Caron Mary Okesola James W. Opzoomer Paris Kosti Mirella Georgouli Peter Gordon Sharanpreet Lall Desislava M. Kuzeva Luisa Pedro Jacqueline D. Shields Cheryl E. Gillett Sandra S. Diebold Victoria Sanz-Moreno Tony Ng Esther Hoste James N. Arnold
author_facet	Tamara Muliaditan Jonathan Caron Mary Okesola James W. Opzoomer Paris Kosti Mirella Georgouli Peter Gordon Sharanpreet Lall Desislava M. Kuzeva Luisa Pedro Jacqueline D. Shields Cheryl E. Gillett Sandra S. Diebold Victoria Sanz-Moreno Tony Ng Esther Hoste James N. Arnold
author_sort	Tamara Muliaditan
title	Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
title_short	Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
title_full	Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
title_fullStr	Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
title_full_unstemmed	Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
title_sort	macrophages are exploited from an innate wound healing response to facilitate cancer metastasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8c66af37aaba412f826bf1e4aabd5fd7
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Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis

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