COVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review

The COVID-19 pandemic and the limited therapeutic arsenal available strain daily clinical practice. Guidelines have recently recommended routine anticoagulation of hospitalized COVID-19 patients. However, apart from the expert panels’ experience, the provenance of this recommendation is not clear, d...

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Autores principales:	Maximiliano Gabriel Castro, Gisel Cuevas
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2021
Materias:	covid-19 sars-cov-2 thrombosis anticoagulation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8c68abe46dd24f6984a34fcc5bf39c37
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spelling	oai:doaj.org-article:8c68abe46dd24f6984a34fcc5bf39c372021-12-02T17:45:29ZCOVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review10.5281/zenodo.45543512695-5075https://doaj.org/article/8c68abe46dd24f6984a34fcc5bf39c372021-02-01T00:00:00Zhttps://doi.org/10.5281/zenodo.4554351https://doaj.org/toc/2695-5075The COVID-19 pandemic and the limited therapeutic arsenal available strain daily clinical practice. Guidelines have recently recommended routine anticoagulation of hospitalized COVID-19 patients. However, apart from the expert panels’ experience, the provenance of this recommendation is not clear, due to the scarce published evidence. We provide a narrative review with the objective of unraveling the rationale for this practice. First, we analyze the biochemical, histopathological and clinical evidence for a pro-thrombotic profile in COVID-19 patients. Then, we present the clinical data from previous studies and discuss to what extent they aid in clinical decision-making. We conclude that, in the absence of randomized controlled trials, which are of utmost importance, prophylactic-dose anticoagulation should be offered to critically ill patients hospitalized for COVID-19 pneumonia, particularly those with high d-dimer levels, since they are the population most likely to benefit from it.Maximiliano Gabriel CastroGisel CuevasEmergency Department of Hospital San Pedro (Logroño, Spain)articlecovid-19sars-cov-2thrombosisanticoagulationMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 3, Iss 2, Pp 122-129 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 sars-cov-2 thrombosis anticoagulation Medicine (General) R5-920
spellingShingle	covid-19 sars-cov-2 thrombosis anticoagulation Medicine (General) R5-920 Maximiliano Gabriel Castro Gisel Cuevas COVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review
description	The COVID-19 pandemic and the limited therapeutic arsenal available strain daily clinical practice. Guidelines have recently recommended routine anticoagulation of hospitalized COVID-19 patients. However, apart from the expert panels’ experience, the provenance of this recommendation is not clear, due to the scarce published evidence. We provide a narrative review with the objective of unraveling the rationale for this practice. First, we analyze the biochemical, histopathological and clinical evidence for a pro-thrombotic profile in COVID-19 patients. Then, we present the clinical data from previous studies and discuss to what extent they aid in clinical decision-making. We conclude that, in the absence of randomized controlled trials, which are of utmost importance, prophylactic-dose anticoagulation should be offered to critically ill patients hospitalized for COVID-19 pneumonia, particularly those with high d-dimer levels, since they are the population most likely to benefit from it.
format	article
author	Maximiliano Gabriel Castro Gisel Cuevas
author_facet	Maximiliano Gabriel Castro Gisel Cuevas
author_sort	Maximiliano Gabriel Castro
title	COVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review
title_short	COVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review
title_full	COVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review
title_fullStr	COVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review
title_full_unstemmed	COVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review
title_sort	covid-19: potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. narrative review
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2021
url	https://doaj.org/article/8c68abe46dd24f6984a34fcc5bf39c37
work_keys_str_mv	AT maximilianogabrielcastro covid19potentialroleofprophylacticanticoagulationinpreventingthromboticeventsandmortalitynarrativereview AT giselcuevas covid19potentialroleofprophylacticanticoagulationinpreventingthromboticeventsandmortalitynarrativereview
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COVID-19: Potential role of prophylactic anticoagulation in preventing thrombotic events and mortality. Narrative review

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