Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy

Danial Mohabati,1,2 Camiel JF Boon,1,3 Suzanne Yzer4 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Department of Ophthalmology, Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands; 3Department of Ophthalmology, Academic Medical Center, University of...

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Autores principales:	Mohabati D, Boon CJF, Yzer S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	acute central serous chorioretinopathy chronic csc photodynamic treatment recurrent csc Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/8c68b7b9ab3e43da894bccf034978f79
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spelling	oai:doaj.org-article:8c68b7b9ab3e43da894bccf034978f792021-12-02T09:55:53ZRisk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy1177-5483https://doaj.org/article/8c68b7b9ab3e43da894bccf034978f792020-04-01T00:00:00Zhttps://www.dovepress.com/risk-of-recurrence-and-transition-to-chronic-disease-in-acute-central--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Danial Mohabati,1,2 Camiel JF Boon,1,3 Suzanne Yzer4 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Department of Ophthalmology, Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands; 3Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; 4Department of Ophthalmology, Rotterdam Eye Hospital, Rotterdam, the NetherlandsCorrespondence: Suzanne YzerRotterdam Eye Hospital, Department of Ophthalmology, Schiedamse Vest 180, Rotterdam 3011 BH, the NetherlandsTel +31-10-4017777Fax +31-10-4017699Email S.Yzer@oogziekenhuis.nlPurpose: To study the risk of recurrence in acute central serous chorioretinopathy (aCSC) and to evaluate the risk of transitioning to chronic CSC.Patients and Methods: The medical records and multimodal imaging data of 295 aCSC cases were reviewed. Typical aCSC was defined as the presence of serous subretinal fluid (SRF), one focal leakage spot on fluorescein angiography (FA), retinal pigment epithelium (RPE) alterations limited in area to less than one optic disc diameter, and complete recovery from this first CSC episode. An increase in RPE alterations combined with persistent SRF was considered a sign of chronicity, which was determined in cases with > 12 months follow-up. The main outcome measures included final visual acuity, percentage of disease recurrence, and percentage of cases moving toward a chronic phenotype. Treatment strategies and their efficacy were also reviewed.Results: A total of 295 eyes in 291 patients with aCSC were included. Spontaneous recovery was awaited in 154 eyes (52%), whereas 141 eyes (48%) recovered following treatment. SRF recurrence occurred in 24% of untreated cases and in 4% of treated cases (p< 0.001). An analysis of 61 eyes that underwent an FA after ≥ 12 months of follow-up revealed increased RPE alterations in 22 eyes (36%), and 14 eyes (23%) had both an increase in RPE alterations and SRF recurrence.Conclusion: All aCSC cases recovered from the first disease episode, and none of the cases developed persistent SRF leakage. Among the cases for which long-term follow-up information was available, 36% showed a tendency toward chronicity in terms of increased RPE alterations, whereas 23% showed both an increase in RPE alterations and recurrent SRF. Early photodynamic therapy (PDT) may decrease the risk of recurrences.Keywords: acute central serous chorioretinopathy, chronic CSC, photodynamic treatment, recurrent CSCMohabati DBoon CJFYzer SDove Medical Pressarticleacute central serous chorioretinopathychronic cscphotodynamic treatmentrecurrent cscOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1165-1175 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute central serous chorioretinopathy chronic csc photodynamic treatment recurrent csc Ophthalmology RE1-994
spellingShingle	acute central serous chorioretinopathy chronic csc photodynamic treatment recurrent csc Ophthalmology RE1-994 Mohabati D Boon CJF Yzer S Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
description	Danial Mohabati,1,2 Camiel JF Boon,1,3 Suzanne Yzer4 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Department of Ophthalmology, Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands; 3Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; 4Department of Ophthalmology, Rotterdam Eye Hospital, Rotterdam, the NetherlandsCorrespondence: Suzanne YzerRotterdam Eye Hospital, Department of Ophthalmology, Schiedamse Vest 180, Rotterdam 3011 BH, the NetherlandsTel +31-10-4017777Fax +31-10-4017699Email S.Yzer@oogziekenhuis.nlPurpose: To study the risk of recurrence in acute central serous chorioretinopathy (aCSC) and to evaluate the risk of transitioning to chronic CSC.Patients and Methods: The medical records and multimodal imaging data of 295 aCSC cases were reviewed. Typical aCSC was defined as the presence of serous subretinal fluid (SRF), one focal leakage spot on fluorescein angiography (FA), retinal pigment epithelium (RPE) alterations limited in area to less than one optic disc diameter, and complete recovery from this first CSC episode. An increase in RPE alterations combined with persistent SRF was considered a sign of chronicity, which was determined in cases with > 12 months follow-up. The main outcome measures included final visual acuity, percentage of disease recurrence, and percentage of cases moving toward a chronic phenotype. Treatment strategies and their efficacy were also reviewed.Results: A total of 295 eyes in 291 patients with aCSC were included. Spontaneous recovery was awaited in 154 eyes (52%), whereas 141 eyes (48%) recovered following treatment. SRF recurrence occurred in 24% of untreated cases and in 4% of treated cases (p< 0.001). An analysis of 61 eyes that underwent an FA after ≥ 12 months of follow-up revealed increased RPE alterations in 22 eyes (36%), and 14 eyes (23%) had both an increase in RPE alterations and SRF recurrence.Conclusion: All aCSC cases recovered from the first disease episode, and none of the cases developed persistent SRF leakage. Among the cases for which long-term follow-up information was available, 36% showed a tendency toward chronicity in terms of increased RPE alterations, whereas 23% showed both an increase in RPE alterations and recurrent SRF. Early photodynamic therapy (PDT) may decrease the risk of recurrences.Keywords: acute central serous chorioretinopathy, chronic CSC, photodynamic treatment, recurrent CSC
format	article
author	Mohabati D Boon CJF Yzer S
author_facet	Mohabati D Boon CJF Yzer S
author_sort	Mohabati D
title	Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
title_short	Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
title_full	Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
title_fullStr	Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
title_full_unstemmed	Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
title_sort	risk of recurrence and transition to chronic disease in acute central serous chorioretinopathy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/8c68b7b9ab3e43da894bccf034978f79
work_keys_str_mv	AT mohabatid riskofrecurrenceandtransitiontochronicdiseaseinacutecentralserouschorioretinopathy AT booncjf riskofrecurrenceandtransitiontochronicdiseaseinacutecentralserouschorioretinopathy AT yzers riskofrecurrenceandtransitiontochronicdiseaseinacutecentralserouschorioretinopathy
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Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy

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