LRPPRC-mediated folding of the mitochondrial transcriptome

The mitochondrial genome, being compressed to 16 kb, is an attractive model system to investigate how RNA-binding proteins chaperone mRNA lifecycles. Here the authors use RNase footprinting and PAR-CLIP to show that the LRPPRC–SLIRP complex stabilizes mRNA structures to expose sites required for tra...

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Autores principales:	Stefan J. Siira, Henrik Spåhr, Anne-Marie J. Shearwood, Benedetta Ruzzenente, Nils-Göran Larsson, Oliver Rackham, Aleksandra Filipovska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c6adab0547346b6a630adf12ab05ecd
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spelling	oai:doaj.org-article:8c6adab0547346b6a630adf12ab05ecd2021-12-02T17:06:19ZLRPPRC-mediated folding of the mitochondrial transcriptome10.1038/s41467-017-01221-z2041-1723https://doaj.org/article/8c6adab0547346b6a630adf12ab05ecd2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01221-zhttps://doaj.org/toc/2041-1723The mitochondrial genome, being compressed to 16 kb, is an attractive model system to investigate how RNA-binding proteins chaperone mRNA lifecycles. Here the authors use RNase footprinting and PAR-CLIP to show that the LRPPRC–SLIRP complex stabilizes mRNA structures to expose sites required for translation and polyadenylation.Stefan J. SiiraHenrik SpåhrAnne-Marie J. ShearwoodBenedetta RuzzenenteNils-Göran LarssonOliver RackhamAleksandra FilipovskaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefan J. Siira Henrik Spåhr Anne-Marie J. Shearwood Benedetta Ruzzenente Nils-Göran Larsson Oliver Rackham Aleksandra Filipovska LRPPRC-mediated folding of the mitochondrial transcriptome
description	The mitochondrial genome, being compressed to 16 kb, is an attractive model system to investigate how RNA-binding proteins chaperone mRNA lifecycles. Here the authors use RNase footprinting and PAR-CLIP to show that the LRPPRC–SLIRP complex stabilizes mRNA structures to expose sites required for translation and polyadenylation.
format	article
author	Stefan J. Siira Henrik Spåhr Anne-Marie J. Shearwood Benedetta Ruzzenente Nils-Göran Larsson Oliver Rackham Aleksandra Filipovska
author_facet	Stefan J. Siira Henrik Spåhr Anne-Marie J. Shearwood Benedetta Ruzzenente Nils-Göran Larsson Oliver Rackham Aleksandra Filipovska
author_sort	Stefan J. Siira
title	LRPPRC-mediated folding of the mitochondrial transcriptome
title_short	LRPPRC-mediated folding of the mitochondrial transcriptome
title_full	LRPPRC-mediated folding of the mitochondrial transcriptome
title_fullStr	LRPPRC-mediated folding of the mitochondrial transcriptome
title_full_unstemmed	LRPPRC-mediated folding of the mitochondrial transcriptome
title_sort	lrpprc-mediated folding of the mitochondrial transcriptome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8c6adab0547346b6a630adf12ab05ecd
work_keys_str_mv	AT stefanjsiira lrpprcmediatedfoldingofthemitochondrialtranscriptome AT henrikspahr lrpprcmediatedfoldingofthemitochondrialtranscriptome AT annemariejshearwood lrpprcmediatedfoldingofthemitochondrialtranscriptome AT benedettaruzzenente lrpprcmediatedfoldingofthemitochondrialtranscriptome AT nilsgoranlarsson lrpprcmediatedfoldingofthemitochondrialtranscriptome AT oliverrackham lrpprcmediatedfoldingofthemitochondrialtranscriptome AT aleksandrafilipovska lrpprcmediatedfoldingofthemitochondrialtranscriptome
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LRPPRC-mediated folding of the mitochondrial transcriptome

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