Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice

Abstract Neovascularization of the erectile tissue emerges as a beneficial curative approach to treat erectile dysfunction (ED). Here we for the first time report the unexpected role of vasohibin-1 (VASH1), mainly known as an anti-angiogenic factor, in restoring erectile function in diabetic mice. A...

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Autores principales:	Kang-Moon Song, Woo Jean Kim, Min-Ji Choi, Ki-Dong Kwon, Anita Limanjaya, Kalyan Ghatak, Jiyeon Ock, Guo Nan Yin, Yasufumi Sato, Soon-Sun Hong, Ji-Kan Ryu, Jun-Kyu Suh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c6bb85a828d408387da62af93415110
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spelling	oai:doaj.org-article:8c6bb85a828d408387da62af934151102021-12-02T15:22:58ZVasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice10.1038/s41598-020-80925-72045-2322https://doaj.org/article/8c6bb85a828d408387da62af934151102021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80925-7https://doaj.org/toc/2045-2322Abstract Neovascularization of the erectile tissue emerges as a beneficial curative approach to treat erectile dysfunction (ED). Here we for the first time report the unexpected role of vasohibin-1 (VASH1), mainly known as an anti-angiogenic factor, in restoring erectile function in diabetic mice. A diabetic patient has lower cavernous VASH1 expression than in the potent man. VASH1 was mainly expressed in endothelial cells. There were significant decreases in cavernous endothelial cell and pericyte contents in VASH1 knockout mice compared with those in wild-type mice, which resulted in impairments in erectile function. Intracavernous injection of VASH1 protein successfully restored erectile function in the diabetic mice (~ 90% of control values). VASH1 protein reinstated endothelial cells, pericytes, and endothelial cell–cell junction proteins and induced phosphorylation of eNOS (Ser1177) in the diabetic mice. The induction of angiogenic factors, such as angiopoietin-1 and vascular endothelial growth factor, is responsible for cavernous angiogenesis and the restoration of erectile function mediated by VASH1. Altogether, these findings suggest that VASH1 is proangiogenic in diabetic penis and is a new potential target for diabetic ED.Kang-Moon SongWoo Jean KimMin-Ji ChoiKi-Dong KwonAnita LimanjayaKalyan GhatakJiyeon OckGuo Nan YinYasufumi SatoSoon-Sun HongJi-Kan RyuJun-Kyu SuhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kang-Moon Song Woo Jean Kim Min-Ji Choi Ki-Dong Kwon Anita Limanjaya Kalyan Ghatak Jiyeon Ock Guo Nan Yin Yasufumi Sato Soon-Sun Hong Ji-Kan Ryu Jun-Kyu Suh Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice
description	Abstract Neovascularization of the erectile tissue emerges as a beneficial curative approach to treat erectile dysfunction (ED). Here we for the first time report the unexpected role of vasohibin-1 (VASH1), mainly known as an anti-angiogenic factor, in restoring erectile function in diabetic mice. A diabetic patient has lower cavernous VASH1 expression than in the potent man. VASH1 was mainly expressed in endothelial cells. There were significant decreases in cavernous endothelial cell and pericyte contents in VASH1 knockout mice compared with those in wild-type mice, which resulted in impairments in erectile function. Intracavernous injection of VASH1 protein successfully restored erectile function in the diabetic mice (~ 90% of control values). VASH1 protein reinstated endothelial cells, pericytes, and endothelial cell–cell junction proteins and induced phosphorylation of eNOS (Ser1177) in the diabetic mice. The induction of angiogenic factors, such as angiopoietin-1 and vascular endothelial growth factor, is responsible for cavernous angiogenesis and the restoration of erectile function mediated by VASH1. Altogether, these findings suggest that VASH1 is proangiogenic in diabetic penis and is a new potential target for diabetic ED.
format	article
author	Kang-Moon Song Woo Jean Kim Min-Ji Choi Ki-Dong Kwon Anita Limanjaya Kalyan Ghatak Jiyeon Ock Guo Nan Yin Yasufumi Sato Soon-Sun Hong Ji-Kan Ryu Jun-Kyu Suh
author_facet	Kang-Moon Song Woo Jean Kim Min-Ji Choi Ki-Dong Kwon Anita Limanjaya Kalyan Ghatak Jiyeon Ock Guo Nan Yin Yasufumi Sato Soon-Sun Hong Ji-Kan Ryu Jun-Kyu Suh
author_sort	Kang-Moon Song
title	Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice
title_short	Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice
title_full	Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice
title_fullStr	Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice
title_full_unstemmed	Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice
title_sort	vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8c6bb85a828d408387da62af93415110
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Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice

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