Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation

Abstract GDF15 is a distant TGF-β family member that induces anorexia and weight loss. Due to its function, GDF15 has attracted attention as a potential therapeutic for the treatment of obesity and its associated metabolic diseases. However, the pharmacokinetic and physicochemical properties of GDF1...

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Autores principales: Ella Fung, Liya Kang, Diana Sapashnik, Susan Benard, Annette Sievers, Yan Liu, Guoying Yan, Jing Zhou, Linette Rodriguez, Weijun Ma, Wayne R. Stochaj, Edward LaVallie, Liliana Wroblewska, Kerry Kelleher, Amy Tam, Olivier Bezy, Danna Breen, Jeffrey R. Chabot, Tao He, Laura Lin, Zhidan Wu, Lidia Mosyak
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/8c6c1df6d01f479188c806163a2d9e3d
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