The RNA-binding protein HuR is required for maintenance of the germinal centre response

The RNA-binding protein HuR is required for maintenance of the germinal centre response

Germinal centre (GC) responses may require RNA binding proteins (RBP) for post-transcriptional gene regulation. Here the authors show the RBP HuR supports GCs by promoting Myc and Myc-dependent transcription to enhance antigen-specific GC B cell selection and production of high affinity antibodies.

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Detalles Bibliográficos
Autores principales: Ines C. Osma-Garcia, Dunja Capitan-Sobrino, Mailys Mouysset, Sarah E. Bell, Manuel Lebeurrier, Martin Turner, Manuel D. Diaz-Muñoz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/8c6df193561843a48b0c03e234de7ff4
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Sumario:Germinal centre (GC) responses may require RNA binding proteins (RBP) for post-transcriptional gene regulation. Here the authors show the RBP HuR supports GCs by promoting Myc and Myc-dependent transcription to enhance antigen-specific GC B cell selection and production of high affinity antibodies.

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