The RNA-binding protein HuR is required for maintenance of the germinal centre response

Germinal centre (GC) responses may require RNA binding proteins (RBP) for post-transcriptional gene regulation. Here the authors show the RBP HuR supports GCs by promoting Myc and Myc-dependent transcription to enhance antigen-specific GC B cell selection and production of high affinity antibodies.

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Autores principales:	Ines C. Osma-Garcia, Dunja Capitan-Sobrino, Mailys Mouysset, Sarah E. Bell, Manuel Lebeurrier, Martin Turner, Manuel D. Diaz-Muñoz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c6df193561843a48b0c03e234de7ff4
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spelling	oai:doaj.org-article:8c6df193561843a48b0c03e234de7ff42021-11-14T12:34:43ZThe RNA-binding protein HuR is required for maintenance of the germinal centre response10.1038/s41467-021-26908-22041-1723https://doaj.org/article/8c6df193561843a48b0c03e234de7ff42021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26908-2https://doaj.org/toc/2041-1723Germinal centre (GC) responses may require RNA binding proteins (RBP) for post-transcriptional gene regulation. Here the authors show the RBP HuR supports GCs by promoting Myc and Myc-dependent transcription to enhance antigen-specific GC B cell selection and production of high affinity antibodies.Ines C. Osma-GarciaDunja Capitan-SobrinoMailys MouyssetSarah E. BellManuel LebeurrierMartin TurnerManuel D. Diaz-MuñozNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ines C. Osma-Garcia Dunja Capitan-Sobrino Mailys Mouysset Sarah E. Bell Manuel Lebeurrier Martin Turner Manuel D. Diaz-Muñoz The RNA-binding protein HuR is required for maintenance of the germinal centre response
description	Germinal centre (GC) responses may require RNA binding proteins (RBP) for post-transcriptional gene regulation. Here the authors show the RBP HuR supports GCs by promoting Myc and Myc-dependent transcription to enhance antigen-specific GC B cell selection and production of high affinity antibodies.
format	article
author	Ines C. Osma-Garcia Dunja Capitan-Sobrino Mailys Mouysset Sarah E. Bell Manuel Lebeurrier Martin Turner Manuel D. Diaz-Muñoz
author_facet	Ines C. Osma-Garcia Dunja Capitan-Sobrino Mailys Mouysset Sarah E. Bell Manuel Lebeurrier Martin Turner Manuel D. Diaz-Muñoz
author_sort	Ines C. Osma-Garcia
title	The RNA-binding protein HuR is required for maintenance of the germinal centre response
title_short	The RNA-binding protein HuR is required for maintenance of the germinal centre response
title_full	The RNA-binding protein HuR is required for maintenance of the germinal centre response
title_fullStr	The RNA-binding protein HuR is required for maintenance of the germinal centre response
title_full_unstemmed	The RNA-binding protein HuR is required for maintenance of the germinal centre response
title_sort	rna-binding protein hur is required for maintenance of the germinal centre response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8c6df193561843a48b0c03e234de7ff4
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The RNA-binding protein HuR is required for maintenance of the germinal centre response

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