The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles

Second generation triazoles are widely used as first-line drugs for the treatment of invasive fungal infections, including aspergillosis and candidiasis. This class, along with itraconazole, voriconazole, posaconazole, and isavuconazole, is characterized by a broad range of activity, however, indivi...

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Autores principales:	Andrzej Czyrski, Matylda Resztak, Paweł Świderski, Jan Brylak, Franciszek K. Główka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug-drug interaction drug-food interaction itraconazole voriconazole ketoconazole isavuconazole Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/8c6f41a950264a1995cf13296a6765fa
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spelling	oai:doaj.org-article:8c6f41a950264a1995cf13296a6765fa2021-11-25T18:42:23ZThe Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles10.3390/pharmaceutics131119611999-4923https://doaj.org/article/8c6f41a950264a1995cf13296a6765fa2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1961https://doaj.org/toc/1999-4923Second generation triazoles are widely used as first-line drugs for the treatment of invasive fungal infections, including aspergillosis and candidiasis. This class, along with itraconazole, voriconazole, posaconazole, and isavuconazole, is characterized by a broad range of activity, however, individual drugs vary considerably in safety, tolerability, pharmacokinetics profiles, and interactions with concomitant medications. The interaction may be encountered on the absorption, distribution, metabolism, and elimination (ADME) step. All triazoles as inhibitors or substrates of CYP isoenzymes can often interact with many drugs, which may result in the change of the activity of the drug and cause serious side effects. Drugs of this class should be used with caution with other agents, and an understanding of their pharmacokinetic profile, safety, and drug-drug interaction profiles is important to provide effective antifungal therapy. The manuscript reviews significant drug interactions of azoles with other medications, as well as with food. The PubMed and Google Scholar bases were searched to collect the literature data. The interactions with anticonvulsants, antibiotics, statins, kinase inhibitors, proton pump inhibitors, non-nucleoside reverse transcriptase inhibitors, opioid analgesics, benzodiazepines, cardiac glycosides, nonsteroidal anti-inflammatory drugs, immunosuppressants, antipsychotics, corticosteroids, biguanides, and anticoagulants are presented. We also paid attention to possible interactions with drugs during experimental therapies for the treatment of COVID-19.Andrzej CzyrskiMatylda ResztakPaweł ŚwiderskiJan BrylakFranciszek K. GłówkaMDPI AGarticledrug-drug interactiondrug-food interactionitraconazolevoriconazoleketoconazoleisavuconazolePharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1961, p 1961 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug-drug interaction drug-food interaction itraconazole voriconazole ketoconazole isavuconazole Pharmacy and materia medica RS1-441
spellingShingle	drug-drug interaction drug-food interaction itraconazole voriconazole ketoconazole isavuconazole Pharmacy and materia medica RS1-441 Andrzej Czyrski Matylda Resztak Paweł Świderski Jan Brylak Franciszek K. Główka The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles
description	Second generation triazoles are widely used as first-line drugs for the treatment of invasive fungal infections, including aspergillosis and candidiasis. This class, along with itraconazole, voriconazole, posaconazole, and isavuconazole, is characterized by a broad range of activity, however, individual drugs vary considerably in safety, tolerability, pharmacokinetics profiles, and interactions with concomitant medications. The interaction may be encountered on the absorption, distribution, metabolism, and elimination (ADME) step. All triazoles as inhibitors or substrates of CYP isoenzymes can often interact with many drugs, which may result in the change of the activity of the drug and cause serious side effects. Drugs of this class should be used with caution with other agents, and an understanding of their pharmacokinetic profile, safety, and drug-drug interaction profiles is important to provide effective antifungal therapy. The manuscript reviews significant drug interactions of azoles with other medications, as well as with food. The PubMed and Google Scholar bases were searched to collect the literature data. The interactions with anticonvulsants, antibiotics, statins, kinase inhibitors, proton pump inhibitors, non-nucleoside reverse transcriptase inhibitors, opioid analgesics, benzodiazepines, cardiac glycosides, nonsteroidal anti-inflammatory drugs, immunosuppressants, antipsychotics, corticosteroids, biguanides, and anticoagulants are presented. We also paid attention to possible interactions with drugs during experimental therapies for the treatment of COVID-19.
format	article
author	Andrzej Czyrski Matylda Resztak Paweł Świderski Jan Brylak Franciszek K. Główka
author_facet	Andrzej Czyrski Matylda Resztak Paweł Świderski Jan Brylak Franciszek K. Główka
author_sort	Andrzej Czyrski
title	The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles
title_short	The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles
title_full	The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles
title_fullStr	The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles
title_full_unstemmed	The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles
title_sort	overview on the pharmacokinetic and pharmacodynamic interactions of triazoles
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8c6f41a950264a1995cf13296a6765fa
work_keys_str_mv	AT andrzejczyrski theoverviewonthepharmacokineticandpharmacodynamicinteractionsoftriazoles AT matyldaresztak theoverviewonthepharmacokineticandpharmacodynamicinteractionsoftriazoles AT pawełswiderski theoverviewonthepharmacokineticandpharmacodynamicinteractionsoftriazoles AT janbrylak theoverviewonthepharmacokineticandpharmacodynamicinteractionsoftriazoles AT franciszekkgłowka theoverviewonthepharmacokineticandpharmacodynamicinteractionsoftriazoles AT andrzejczyrski overviewonthepharmacokineticandpharmacodynamicinteractionsoftriazoles AT matyldaresztak overviewonthepharmacokineticandpharmacodynamicinteractionsoftriazoles AT pawełswiderski overviewonthepharmacokineticandpharmacodynamicinteractionsoftriazoles AT janbrylak overviewonthepharmacokineticandpharmacodynamicinteractionsoftriazoles AT franciszekkgłowka overviewonthepharmacokineticandpharmacodynamicinteractionsoftriazoles
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The Overview on the Pharmacokinetic and Pharmacodynamic Interactions of Triazoles

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