Tracing TB: Are there predictors for active TB disease in patients with Xpert Ultra trace results?

Objectives: The Xpert MTB/Rif Ultra (Xpert Ultra; Cepheid, USA) has increased sensitivity compared with its predecessor (Gene Xpert), due to the addition of multicopy amplification targets and a novel trace call. The World Health Organization suggests that tuberculosis (TB) treatment should be initi...

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Autores principales:	Wentzel Bruce Dowling, Andrew Whitelaw, Pieter Nel
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Xpert Ultra Mycobacterium tuberculosis TB culture Trace results Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/8c702860b48b46ee83f57904a3892c32
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spelling	oai:doaj.org-article:8c702860b48b46ee83f57904a3892c322021-11-28T04:29:16ZTracing TB: Are there predictors for active TB disease in patients with Xpert Ultra trace results?1201-971210.1016/j.ijid.2021.10.056https://doaj.org/article/8c702860b48b46ee83f57904a3892c322022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221008456https://doaj.org/toc/1201-9712Objectives: The Xpert MTB/Rif Ultra (Xpert Ultra; Cepheid, USA) has increased sensitivity compared with its predecessor (Gene Xpert), due to the addition of multicopy amplification targets and a novel trace call. The World Health Organization suggests that tuberculosis (TB) treatment should be initiated in HIV, paediatric, and extra-pulmonary TB patients with trace results. However, other factors such as previous TB disease may complicate the interpretation of trace results in high-burden TB settings. This study aimed to clarify the positive predictors for active TB disease in patients with trace results and to investigate if previous TB disease influences TB culture positivity. Methods: A retrospective descriptive study was performed on 290 patients with trace results, to determine what the positive predictors for active TB are by comparing clinical factors to TB culture. Results: The key findings of this study were that extra-pulmonary TB samples (OR, 2.7; p=0.012), no previous TB disease (OR, 4.5; p=0.001) and symptoms suggestive of TB (OR, 6.4; p<0.001) are independent predictors for active TB disease. Conclusion: This study found readily available clinical predictors that can aid clinicians with TB management decisions in patients with trace results.Wentzel Bruce DowlingAndrew WhitelawPieter NelElsevierarticleXpert UltraMycobacterium tuberculosisTB cultureTrace resultsInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 114, Iss , Pp 115-123 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Xpert Ultra Mycobacterium tuberculosis TB culture Trace results Infectious and parasitic diseases RC109-216
spellingShingle	Xpert Ultra Mycobacterium tuberculosis TB culture Trace results Infectious and parasitic diseases RC109-216 Wentzel Bruce Dowling Andrew Whitelaw Pieter Nel Tracing TB: Are there predictors for active TB disease in patients with Xpert Ultra trace results?
description	Objectives: The Xpert MTB/Rif Ultra (Xpert Ultra; Cepheid, USA) has increased sensitivity compared with its predecessor (Gene Xpert), due to the addition of multicopy amplification targets and a novel trace call. The World Health Organization suggests that tuberculosis (TB) treatment should be initiated in HIV, paediatric, and extra-pulmonary TB patients with trace results. However, other factors such as previous TB disease may complicate the interpretation of trace results in high-burden TB settings. This study aimed to clarify the positive predictors for active TB disease in patients with trace results and to investigate if previous TB disease influences TB culture positivity. Methods: A retrospective descriptive study was performed on 290 patients with trace results, to determine what the positive predictors for active TB are by comparing clinical factors to TB culture. Results: The key findings of this study were that extra-pulmonary TB samples (OR, 2.7; p=0.012), no previous TB disease (OR, 4.5; p=0.001) and symptoms suggestive of TB (OR, 6.4; p<0.001) are independent predictors for active TB disease. Conclusion: This study found readily available clinical predictors that can aid clinicians with TB management decisions in patients with trace results.
format	article
author	Wentzel Bruce Dowling Andrew Whitelaw Pieter Nel
author_facet	Wentzel Bruce Dowling Andrew Whitelaw Pieter Nel
author_sort	Wentzel Bruce Dowling
title	Tracing TB: Are there predictors for active TB disease in patients with Xpert Ultra trace results?
title_short	Tracing TB: Are there predictors for active TB disease in patients with Xpert Ultra trace results?
title_full	Tracing TB: Are there predictors for active TB disease in patients with Xpert Ultra trace results?
title_fullStr	Tracing TB: Are there predictors for active TB disease in patients with Xpert Ultra trace results?
title_full_unstemmed	Tracing TB: Are there predictors for active TB disease in patients with Xpert Ultra trace results?
title_sort	tracing tb: are there predictors for active tb disease in patients with xpert ultra trace results?
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/8c702860b48b46ee83f57904a3892c32
work_keys_str_mv	AT wentzelbrucedowling tracingtbaretherepredictorsforactivetbdiseaseinpatientswithxpertultratraceresults AT andrewwhitelaw tracingtbaretherepredictorsforactivetbdiseaseinpatientswithxpertultratraceresults AT pieternel tracingtbaretherepredictorsforactivetbdiseaseinpatientswithxpertultratraceresults
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Tracing TB: Are there predictors for active TB disease in patients with Xpert Ultra trace results?

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