Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition

Abstract The abnormal intrauterine milieu of fetal growth retardation could lead to dyslipidemia in adulthood. Studies have shown that growth hormone (GH) therapy in small for gestational age (SGA) children would be beneficial for metabolic parameters. Here we investigated whether GH treatment intro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wei-fen Zhu, Sheng-jie Tang, Zheng Shen, Ying-min Wang, Li Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c709b5bff924dbbb567f70895cfce37
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8c709b5bff924dbbb567f70895cfce37
record_format	dspace
spelling	oai:doaj.org-article:8c709b5bff924dbbb567f70895cfce372021-12-02T11:52:58ZGrowth hormone reverses dyslipidemia in adult offspring after maternal undernutrition10.1038/s41598-017-05045-12045-2322https://doaj.org/article/8c709b5bff924dbbb567f70895cfce372017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05045-1https://doaj.org/toc/2045-2322Abstract The abnormal intrauterine milieu of fetal growth retardation could lead to dyslipidemia in adulthood. Studies have shown that growth hormone (GH) therapy in small for gestational age (SGA) children would be beneficial for metabolic parameters. Here we investigated whether GH treatment introduced at adolescent period in SGA could reverse dyslipidemia during later life. SGA rat model was established by using semi-starvation treatment during the whole pregnancy. SGA or appropriate for gestational age (AGA) offspring were assigned to receive GH or normal saline (NS). Once-daily subcutaneous injections of GH were administered between 21–35 days of age. In adulthood, as compared to AGA, SGA showed: (1) decreased body weight and length; (2) increased serum triglycerides; (3) down-regulated hepatic AMPK-α1 but up-regulated SREBP-1c and ACC-1; (4) a significant reduction in histone H3 acetylation at the promoter of AMPK-α1. Exogenous GH administration led to a restoration of body weight and length and normalized serum triglycerides by reversing expression of AMPK-α1 and its targeted genes SREBP-1c and ACC-1, through increasing H3 acetylation at the promoter of AMPK-α1 in SGA in adult period. These results demonstrated positive effects on lipid metabolism by a short treatment course of GH in SGA adult period.Wei-fen ZhuSheng-jie TangZheng ShenYing-min WangLi LiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei-fen Zhu Sheng-jie Tang Zheng Shen Ying-min Wang Li Liang Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition
description	Abstract The abnormal intrauterine milieu of fetal growth retardation could lead to dyslipidemia in adulthood. Studies have shown that growth hormone (GH) therapy in small for gestational age (SGA) children would be beneficial for metabolic parameters. Here we investigated whether GH treatment introduced at adolescent period in SGA could reverse dyslipidemia during later life. SGA rat model was established by using semi-starvation treatment during the whole pregnancy. SGA or appropriate for gestational age (AGA) offspring were assigned to receive GH or normal saline (NS). Once-daily subcutaneous injections of GH were administered between 21–35 days of age. In adulthood, as compared to AGA, SGA showed: (1) decreased body weight and length; (2) increased serum triglycerides; (3) down-regulated hepatic AMPK-α1 but up-regulated SREBP-1c and ACC-1; (4) a significant reduction in histone H3 acetylation at the promoter of AMPK-α1. Exogenous GH administration led to a restoration of body weight and length and normalized serum triglycerides by reversing expression of AMPK-α1 and its targeted genes SREBP-1c and ACC-1, through increasing H3 acetylation at the promoter of AMPK-α1 in SGA in adult period. These results demonstrated positive effects on lipid metabolism by a short treatment course of GH in SGA adult period.
format	article
author	Wei-fen Zhu Sheng-jie Tang Zheng Shen Ying-min Wang Li Liang
author_facet	Wei-fen Zhu Sheng-jie Tang Zheng Shen Ying-min Wang Li Liang
author_sort	Wei-fen Zhu
title	Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition
title_short	Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition
title_full	Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition
title_fullStr	Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition
title_full_unstemmed	Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition
title_sort	growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8c709b5bff924dbbb567f70895cfce37
work_keys_str_mv	AT weifenzhu growthhormonereversesdyslipidemiainadultoffspringaftermaternalundernutrition AT shengjietang growthhormonereversesdyslipidemiainadultoffspringaftermaternalundernutrition AT zhengshen growthhormonereversesdyslipidemiainadultoffspringaftermaternalundernutrition AT yingminwang growthhormonereversesdyslipidemiainadultoffspringaftermaternalundernutrition AT liliang growthhormonereversesdyslipidemiainadultoffspringaftermaternalundernutrition
_version_	1718394938467549184

Growth hormone reverses dyslipidemia in adult offspring after maternal undernutrition

Ejemplares similares