Current and emerging treatments for amyotrophic lateral sclerosis

Stefano Zoccolella1, Andrea Santamato2, Paolo Lamberti31Azienda Ospedaliero-UniversitariaOspedali Riuniti, Department of Medical and Neurological Sciences, Clinic of Nervous System Diseases, University of Foggia, Italy; 2Department of Physical Medicine and Rehabilitation, University of Foggia, OORR,...

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Autores principales:	Stefano Zoccolella, Andrea Santamato, Paolo Lamberti
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8c7354c611d24e3fa1f71f95ba79cd21
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spelling	oai:doaj.org-article:8c7354c611d24e3fa1f71f95ba79cd212021-12-02T00:48:16ZCurrent and emerging treatments for amyotrophic lateral sclerosis1176-63281178-2021https://doaj.org/article/8c7354c611d24e3fa1f71f95ba79cd212009-11-01T00:00:00Zhttp://www.dovepress.com/current-and-emerging-treatments-for-amyotrophic-lateral-sclerosis-a3691https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Stefano Zoccolella1, Andrea Santamato2, Paolo Lamberti31Azienda Ospedaliero-UniversitariaOspedali Riuniti, Department of Medical and Neurological Sciences, Clinic of Nervous System Diseases, University of Foggia, Italy; 2Department of Physical Medicine and Rehabilitation, University of Foggia, OORR, Italy; 3Department of Neurology and Psychiatry, University of Bari, ItalyBackground: Amyotrophic lateral sclerosis (ALS) is a relatively rare neurodegenerative disorder of both upper and lower motoneurons. Currently, the management of ALS is essentially symptoms-based, and riluzole, an antiglutamatergic agent, is the only drug for the treatment of ALS approved by the food and drug administration.Objective: We reviewed current literature concerning emerging treatments for amyotrophic lateral sclerosis.Methods: A Medline literature search was performed to identify all studies on ALS treatment published from January 1st, 1986 through August 31st, 2009. We selected papers concerning only disease-modifying therapy.Results: Forty-eight compounds were identified and reviewed in this study.Conclusions: Riluzole is the only compound that demonstrated a beneficial effect on ALS patients, but with only modest increase in survival. Although several drugs showed effective results in the animal models for ALS, none of them significantly prolonged survival or improved quality of life of ALS patients. Several factors have been implicated in explaining the predominantly negative results of numerous randomized clinical trials in ALS, including methodological problems in the use of animal-drug screening, the lack of assessment of pharmacokinetic profile of the drugs, and methodological pitfalls of clinical trials in ALS patients.Keywords: amyotrophic lateral sclerosis, therapy, drug, survival Stefano ZoccolellaAndrea SantamatoPaolo LambertiDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 577-595 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Stefano Zoccolella Andrea Santamato Paolo Lamberti Current and emerging treatments for amyotrophic lateral sclerosis
description	Stefano Zoccolella1, Andrea Santamato2, Paolo Lamberti31Azienda Ospedaliero-UniversitariaOspedali Riuniti, Department of Medical and Neurological Sciences, Clinic of Nervous System Diseases, University of Foggia, Italy; 2Department of Physical Medicine and Rehabilitation, University of Foggia, OORR, Italy; 3Department of Neurology and Psychiatry, University of Bari, ItalyBackground: Amyotrophic lateral sclerosis (ALS) is a relatively rare neurodegenerative disorder of both upper and lower motoneurons. Currently, the management of ALS is essentially symptoms-based, and riluzole, an antiglutamatergic agent, is the only drug for the treatment of ALS approved by the food and drug administration.Objective: We reviewed current literature concerning emerging treatments for amyotrophic lateral sclerosis.Methods: A Medline literature search was performed to identify all studies on ALS treatment published from January 1st, 1986 through August 31st, 2009. We selected papers concerning only disease-modifying therapy.Results: Forty-eight compounds were identified and reviewed in this study.Conclusions: Riluzole is the only compound that demonstrated a beneficial effect on ALS patients, but with only modest increase in survival. Although several drugs showed effective results in the animal models for ALS, none of them significantly prolonged survival or improved quality of life of ALS patients. Several factors have been implicated in explaining the predominantly negative results of numerous randomized clinical trials in ALS, including methodological problems in the use of animal-drug screening, the lack of assessment of pharmacokinetic profile of the drugs, and methodological pitfalls of clinical trials in ALS patients.Keywords: amyotrophic lateral sclerosis, therapy, drug, survival
format	article
author	Stefano Zoccolella Andrea Santamato Paolo Lamberti
author_facet	Stefano Zoccolella Andrea Santamato Paolo Lamberti
author_sort	Stefano Zoccolella
title	Current and emerging treatments for amyotrophic lateral sclerosis
title_short	Current and emerging treatments for amyotrophic lateral sclerosis
title_full	Current and emerging treatments for amyotrophic lateral sclerosis
title_fullStr	Current and emerging treatments for amyotrophic lateral sclerosis
title_full_unstemmed	Current and emerging treatments for amyotrophic lateral sclerosis
title_sort	current and emerging treatments for amyotrophic lateral sclerosis
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/8c7354c611d24e3fa1f71f95ba79cd21
work_keys_str_mv	AT stefanozoccolella currentandemergingtreatmentsforamyotrophiclateralsclerosis AT andreasantamato currentandemergingtreatmentsforamyotrophiclateralsclerosis AT paololamberti currentandemergingtreatmentsforamyotrophiclateralsclerosis
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Current and emerging treatments for amyotrophic lateral sclerosis

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