Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer

Abstract The vast majority of studies investigating immune checkpoint inhibition (ICI) in patients with breast cancer have focused on triple-negative breast cancer (TNBC). In this study, we compared the tumor immune microenvironment (TIME) between TNBC and hormone receptor-negative HER2-positive bre...

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Autores principales:	Hanne Vos, Kathleen Lambein, François Richard, Bram Mariën, Ines Nevelsteen, Kevin Punie, Hans Wildiers, Lieze Berben, Annouschka Laenen, Giuseppe Floris, Christine Desmedt, Ann Smeets
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8c78a70e9b4d4db798014a17106372d6
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spelling	oai:doaj.org-article:8c78a70e9b4d4db798014a17106372d62021-12-02T18:48:11ZComparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer10.1038/s41523-021-00332-72374-4677https://doaj.org/article/8c78a70e9b4d4db798014a17106372d62021-09-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00332-7https://doaj.org/toc/2374-4677Abstract The vast majority of studies investigating immune checkpoint inhibition (ICI) in patients with breast cancer have focused on triple-negative breast cancer (TNBC). In this study, we compared the tumor immune microenvironment (TIME) between TNBC and hormone receptor-negative HER2-positive breast cancer based on a selection of immune markers at the protein level in an institutional retrospective series. Additionally, we performed a similar comparison using publicly available transcriptomics data. Altogether, the results show a comparable TIME in both groups, with possible implications for the use of ICI in patients with hormone receptor-negative HER2-positive breast tumors.Hanne VosKathleen LambeinFrançois RichardBram MariënInes NevelsteenKevin PunieHans WildiersLieze BerbenAnnouschka LaenenGiuseppe FlorisChristine DesmedtAnn SmeetsNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hanne Vos Kathleen Lambein François Richard Bram Mariën Ines Nevelsteen Kevin Punie Hans Wildiers Lieze Berben Annouschka Laenen Giuseppe Floris Christine Desmedt Ann Smeets Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer
description	Abstract The vast majority of studies investigating immune checkpoint inhibition (ICI) in patients with breast cancer have focused on triple-negative breast cancer (TNBC). In this study, we compared the tumor immune microenvironment (TIME) between TNBC and hormone receptor-negative HER2-positive breast cancer based on a selection of immune markers at the protein level in an institutional retrospective series. Additionally, we performed a similar comparison using publicly available transcriptomics data. Altogether, the results show a comparable TIME in both groups, with possible implications for the use of ICI in patients with hormone receptor-negative HER2-positive breast tumors.
format	article
author	Hanne Vos Kathleen Lambein François Richard Bram Mariën Ines Nevelsteen Kevin Punie Hans Wildiers Lieze Berben Annouschka Laenen Giuseppe Floris Christine Desmedt Ann Smeets
author_facet	Hanne Vos Kathleen Lambein François Richard Bram Mariën Ines Nevelsteen Kevin Punie Hans Wildiers Lieze Berben Annouschka Laenen Giuseppe Floris Christine Desmedt Ann Smeets
author_sort	Hanne Vos
title	Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer
title_short	Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer
title_full	Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer
title_fullStr	Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer
title_full_unstemmed	Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer
title_sort	comparison of the tumor immune microenvironment of primary hormone receptor-negative her2-positive and triple negative breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8c78a70e9b4d4db798014a17106372d6
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Comparison of the tumor immune microenvironment of primary hormone receptor-negative HER2-positive and triple negative breast cancer

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