Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar.

Between October 2001 and April 2002, five cases of acute flaccid paralysis (AFP) associated with type 2 vaccine-derived polioviruses (VDPVs) were reported in the southern province of the Republic of Madagascar. To determine viral factors that favor the emergence of these pathogenic VDPVs, we analyze...

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Autores principales:	Mala Rakoto-Andrianarivelo, Sophie Guillot, Jane Iber, Jean Balanant, Bruno Blondel, Franck Riquet, Javier Martin, Olen Kew, Bakolalao Randriamanalina, Lalatiana Razafinimpiasa, Dominique Rousset, Francis Delpeyroux
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8c797f9b67ab40859cf62d0a318aa758
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spelling	oai:doaj.org-article:8c797f9b67ab40859cf62d0a318aa7582021-11-25T05:46:48ZCo-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar.1553-73661553-737410.1371/journal.ppat.0030191https://doaj.org/article/8c797f9b67ab40859cf62d0a318aa7582007-12-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.0030191https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Between October 2001 and April 2002, five cases of acute flaccid paralysis (AFP) associated with type 2 vaccine-derived polioviruses (VDPVs) were reported in the southern province of the Republic of Madagascar. To determine viral factors that favor the emergence of these pathogenic VDPVs, we analyzed in detail their genomic and phenotypic characteristics and compared them with co-circulating enteroviruses. These VDPVs appeared to belong to two independent recombinant lineages with sequences from the type 2 strain of the oral poliovaccine (OPV) in the 5'-half of the genome and sequences derived from unidentified species C enteroviruses (HEV-C) in the 3'-half. VDPV strains showed characteristics similar to those of wild neurovirulent viruses including neurovirulence in poliovirus-receptor transgenic mice. We looked for other VDPVs and for circulating enteroviruses in 316 stools collected from healthy children living in the small area where most of the AFP cases occurred. We found vaccine PVs, two VDPVs similar to those found in AFP cases, some echoviruses, and above all, many serotypes of coxsackie A viruses belonging to HEV-C, with substantial genetic diversity. Several coxsackie viruses A17 and A13 carried nucleotide sequences closely related to the 2C and the 3D(pol) coding regions of the VDPVs, respectively. There was also evidence of multiple genetic recombination events among the HEV-C resulting in numerous recombinant genotypes. This indicates that co-circulation of HEV-C and OPV strains is associated with evolution by recombination, resulting in unexpectedly extensive viral diversity in small human populations in some tropical regions. This probably contributed to the emergence of recombinant VDPVs. These findings give further insight into viral ecosystems and the evolutionary processes that shape viral biodiversity.Mala Rakoto-AndrianariveloSophie GuillotJane IberJean BalanantBruno BlondelFranck RiquetJavier MartinOlen KewBakolalao RandriamanalinaLalatiana RazafinimpiasaDominique RoussetFrancis DelpeyrouxPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 3, Iss 12, p e191 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Mala Rakoto-Andrianarivelo Sophie Guillot Jane Iber Jean Balanant Bruno Blondel Franck Riquet Javier Martin Olen Kew Bakolalao Randriamanalina Lalatiana Razafinimpiasa Dominique Rousset Francis Delpeyroux Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar.
description	Between October 2001 and April 2002, five cases of acute flaccid paralysis (AFP) associated with type 2 vaccine-derived polioviruses (VDPVs) were reported in the southern province of the Republic of Madagascar. To determine viral factors that favor the emergence of these pathogenic VDPVs, we analyzed in detail their genomic and phenotypic characteristics and compared them with co-circulating enteroviruses. These VDPVs appeared to belong to two independent recombinant lineages with sequences from the type 2 strain of the oral poliovaccine (OPV) in the 5'-half of the genome and sequences derived from unidentified species C enteroviruses (HEV-C) in the 3'-half. VDPV strains showed characteristics similar to those of wild neurovirulent viruses including neurovirulence in poliovirus-receptor transgenic mice. We looked for other VDPVs and for circulating enteroviruses in 316 stools collected from healthy children living in the small area where most of the AFP cases occurred. We found vaccine PVs, two VDPVs similar to those found in AFP cases, some echoviruses, and above all, many serotypes of coxsackie A viruses belonging to HEV-C, with substantial genetic diversity. Several coxsackie viruses A17 and A13 carried nucleotide sequences closely related to the 2C and the 3D(pol) coding regions of the VDPVs, respectively. There was also evidence of multiple genetic recombination events among the HEV-C resulting in numerous recombinant genotypes. This indicates that co-circulation of HEV-C and OPV strains is associated with evolution by recombination, resulting in unexpectedly extensive viral diversity in small human populations in some tropical regions. This probably contributed to the emergence of recombinant VDPVs. These findings give further insight into viral ecosystems and the evolutionary processes that shape viral biodiversity.
format	article
author	Mala Rakoto-Andrianarivelo Sophie Guillot Jane Iber Jean Balanant Bruno Blondel Franck Riquet Javier Martin Olen Kew Bakolalao Randriamanalina Lalatiana Razafinimpiasa Dominique Rousset Francis Delpeyroux
author_facet	Mala Rakoto-Andrianarivelo Sophie Guillot Jane Iber Jean Balanant Bruno Blondel Franck Riquet Javier Martin Olen Kew Bakolalao Randriamanalina Lalatiana Razafinimpiasa Dominique Rousset Francis Delpeyroux
author_sort	Mala Rakoto-Andrianarivelo
title	Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar.
title_short	Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar.
title_full	Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar.
title_fullStr	Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar.
title_full_unstemmed	Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar.
title_sort	co-circulation and evolution of polioviruses and species c enteroviruses in a district of madagascar.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/8c797f9b67ab40859cf62d0a318aa758
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Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar.

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