Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

WalKR is an essential two-component regulator that controls peptidoglycan synthesis in the human pathogen Staphylococcus aureus. Here, the authors provide biochemical, structural, and functional evidence supporting that the binding of a zinc ion inhibits autophosphorylation and thus alters WalKR reg...

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Autores principales:	Ian R. Monk, Nausad Shaikh, Stephanie L. Begg, Mike Gajdiss, Liam K. R. Sharkey, Jean Y. H. Lee, Sacha J. Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M. Collins, Gabriele Bierbaum, Saumya R. Udagedara, Jacqueline R. Morey, Neha Pulyani, Benjamin P. Howden, Megan J. Maher, Christopher A. McDevitt, Glenn F. King, Timothy P. Stinear
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c79c77e7e1c43c2b593eb5939e70c11
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:8c79c77e7e1c43c2b593eb5939e70c112021-12-02T15:35:39ZZinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus10.1038/s41467-019-10932-42041-1723https://doaj.org/article/8c79c77e7e1c43c2b593eb5939e70c112019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10932-4https://doaj.org/toc/2041-1723WalKR is an essential two-component regulator that controls peptidoglycan synthesis in the human pathogen Staphylococcus aureus. Here, the authors provide biochemical, structural, and functional evidence supporting that the binding of a zinc ion inhibits autophosphorylation and thus alters WalKR regulatory activity.Ian R. MonkNausad ShaikhStephanie L. BeggMike GajdissLiam K. R. SharkeyJean Y. H. LeeSacha J. PidotTorsten SeemannMichael KuiperBrit WinnenRikki HvorupBrett M. CollinsGabriele BierbaumSaumya R. UdagedaraJacqueline R. MoreyNeha PulyaniBenjamin P. HowdenMegan J. MaherChristopher A. McDevittGlenn F. KingTimothy P. StinearNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ian R. Monk Nausad Shaikh Stephanie L. Begg Mike Gajdiss Liam K. R. Sharkey Jean Y. H. Lee Sacha J. Pidot Torsten Seemann Michael Kuiper Brit Winnen Rikki Hvorup Brett M. Collins Gabriele Bierbaum Saumya R. Udagedara Jacqueline R. Morey Neha Pulyani Benjamin P. Howden Megan J. Maher Christopher A. McDevitt Glenn F. King Timothy P. Stinear Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
description	WalKR is an essential two-component regulator that controls peptidoglycan synthesis in the human pathogen Staphylococcus aureus. Here, the authors provide biochemical, structural, and functional evidence supporting that the binding of a zinc ion inhibits autophosphorylation and thus alters WalKR regulatory activity.
format	article
author	Ian R. Monk Nausad Shaikh Stephanie L. Begg Mike Gajdiss Liam K. R. Sharkey Jean Y. H. Lee Sacha J. Pidot Torsten Seemann Michael Kuiper Brit Winnen Rikki Hvorup Brett M. Collins Gabriele Bierbaum Saumya R. Udagedara Jacqueline R. Morey Neha Pulyani Benjamin P. Howden Megan J. Maher Christopher A. McDevitt Glenn F. King Timothy P. Stinear
author_facet	Ian R. Monk Nausad Shaikh Stephanie L. Begg Mike Gajdiss Liam K. R. Sharkey Jean Y. H. Lee Sacha J. Pidot Torsten Seemann Michael Kuiper Brit Winnen Rikki Hvorup Brett M. Collins Gabriele Bierbaum Saumya R. Udagedara Jacqueline R. Morey Neha Pulyani Benjamin P. Howden Megan J. Maher Christopher A. McDevitt Glenn F. King Timothy P. Stinear
author_sort	Ian R. Monk
title	Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
title_short	Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
title_full	Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
title_fullStr	Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
title_full_unstemmed	Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
title_sort	zinc-binding to the cytoplasmic pas domain regulates the essential walk histidine kinase of staphylococcus aureus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8c79c77e7e1c43c2b593eb5939e70c11
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Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

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