Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.

<h4>Unlabelled</h4>Capsaicin, the most abundant pungent molecule produced by pepper plants, represents an important ingredient in spicy foods consumed throughout the world. Studies have shown that capsaicin can relieve inflammation and has anti-proliferative effects on various human mali...

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Autores principales:	Annika Wutka, Vindhya Palagani, Samarpita Barat, Xi Chen, Mona El Khatib, Julian Götze, Hanane Belahmer, Steffen Zender, Przemyslaw Bozko, Nisar P Malek, Ruben R Plentz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c7b76e2563c4dbdaf77480843917111
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spelling	oai:doaj.org-article:8c7b76e2563c4dbdaf774808439171112021-11-18T08:22:24ZCapsaicin treatment attenuates cholangiocarcinoma carcinogenesis.1932-620310.1371/journal.pone.0095605https://doaj.org/article/8c7b76e2563c4dbdaf774808439171112014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24748170/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Unlabelled</h4>Capsaicin, the most abundant pungent molecule produced by pepper plants, represents an important ingredient in spicy foods consumed throughout the world. Studies have shown that capsaicin can relieve inflammation and has anti-proliferative effects on various human malignancies. Cholangiocarcinoma (CC) is a cancer disease with rising incidence. The prognosis remains dismal with little advance in treatment. The aim of the present study is to explore the anti-tumor activity of capsaicin in cultured human CC cell lines. Capsaicin effectively impaired cell proliferation, migration, invasion, epithelial to mesenchymal transition and growth of softagar colonies. Further, we show that capsaicin treatment of CC cells regulates the Hedgehog signaling pathway.<h4>Conclusion</h4>Our results provide a basis for capsaicin to improve the prognosis of CCs in vivo and present new insights into the effectiveness and mode of action of capsaicin.Annika WutkaVindhya PalaganiSamarpita BaratXi ChenMona El KhatibJulian GötzeHanane BelahmerSteffen ZenderPrzemyslaw BozkoNisar P MalekRuben R PlentzPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e95605 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Annika Wutka Vindhya Palagani Samarpita Barat Xi Chen Mona El Khatib Julian Götze Hanane Belahmer Steffen Zender Przemyslaw Bozko Nisar P Malek Ruben R Plentz Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.
description	<h4>Unlabelled</h4>Capsaicin, the most abundant pungent molecule produced by pepper plants, represents an important ingredient in spicy foods consumed throughout the world. Studies have shown that capsaicin can relieve inflammation and has anti-proliferative effects on various human malignancies. Cholangiocarcinoma (CC) is a cancer disease with rising incidence. The prognosis remains dismal with little advance in treatment. The aim of the present study is to explore the anti-tumor activity of capsaicin in cultured human CC cell lines. Capsaicin effectively impaired cell proliferation, migration, invasion, epithelial to mesenchymal transition and growth of softagar colonies. Further, we show that capsaicin treatment of CC cells regulates the Hedgehog signaling pathway.<h4>Conclusion</h4>Our results provide a basis for capsaicin to improve the prognosis of CCs in vivo and present new insights into the effectiveness and mode of action of capsaicin.
format	article
author	Annika Wutka Vindhya Palagani Samarpita Barat Xi Chen Mona El Khatib Julian Götze Hanane Belahmer Steffen Zender Przemyslaw Bozko Nisar P Malek Ruben R Plentz
author_facet	Annika Wutka Vindhya Palagani Samarpita Barat Xi Chen Mona El Khatib Julian Götze Hanane Belahmer Steffen Zender Przemyslaw Bozko Nisar P Malek Ruben R Plentz
author_sort	Annika Wutka
title	Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.
title_short	Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.
title_full	Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.
title_fullStr	Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.
title_full_unstemmed	Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.
title_sort	capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/8c7b76e2563c4dbdaf77480843917111
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Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis.

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