Risk Factors of Pleural Effusion Following Pediatric Liver Transplantation and the Perioperative Outcomes

Chollasak Thirapattaraphan,1,2 Prapatsorn Srina,1 Ampaipan Boonthai,1,2 Nuttapon Arpornsujaritkun,2,3 Bundit Sakulchairungrueng,2,3 Worapot Apinyachon,2,4 Suporn Treepongkaruna2,5 1Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Ban...

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Autores principales:	Thirapattaraphan C, Srina P, Boonthai A, Arpornsujaritkun N, Sakulchairungrueng B, Apinyachon W, Treepongkaruna S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	pleural effusion pediatric liver transplantation liver transplantation post-liver transplant pleural effusion pulmonary complications Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8c7d5a4206e64ad488e0dfb645cd8d5e
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spelling	oai:doaj.org-article:8c7d5a4206e64ad488e0dfb645cd8d5e2021-12-02T12:09:07ZRisk Factors of Pleural Effusion Following Pediatric Liver Transplantation and the Perioperative Outcomes1179-1616https://doaj.org/article/8c7d5a4206e64ad488e0dfb645cd8d5e2020-11-01T00:00:00Zhttps://www.dovepress.com/risk-factors-of-pleural-effusion-following-pediatric-liver-transplanta-peer-reviewed-article-TRRMhttps://doaj.org/toc/1179-1616Chollasak Thirapattaraphan,1,2 Prapatsorn Srina,1 Ampaipan Boonthai,1,2 Nuttapon Arpornsujaritkun,2,3 Bundit Sakulchairungrueng,2,3 Worapot Apinyachon,2,4 Suporn Treepongkaruna2,5 1Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Ramathibodi Excellent Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Division of Vascular Surgery and Transplantation, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 4Department of Anesthesiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 5Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Suporn TreepongkarunaDivision of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok 10400, ThailandTel/Fax +6622011446Email suporntr@gmail.comBackground: Pediatric liver transplantation (LT) has been accepted as a definitive treatment for end-stage liver disease. Pleural effusion is a common pulmonary complication following LT in children. The objectives of the study were to identify prevalence of post-LT pleural effusion, risk factors, and the impact on patients’ outcomes.Methods: A retrospective study was conducted in 107 pediatric patients who underwent LT at our center between March 2001 and June 2018. They were categorized into pleural effusion and non-pleural effusion groups. Preoperative and perioperative data, intraoperative findings, liver graft characteristics, and perioperative outcomes were compared between the two groups.Results: Post-LT pleural effusion occurred in 64 (59.8%) patients. There were more patients with PELD score ≥ 18 in the pleural effusion group (68.8 vs 48.8%, P=0.039). Other preoperative and perioperative data were not significantly different. The pleural effusion group had a higher rate of reoperation than non-pleural effusion group (55.6 vs 30.9%, P=0.013). Median oxygen dependence time, length of ICU and hospital stay were significantly longer in the pleural effusion group (18.5 vs 7.0, 10 vs 7 and 48 vs 34 days, respectively, P < 0.05). However, mortality was not significantly different. Among the patients with pleural effusion, median time to extubation, oxygen dependence time, length of ICU and hospital stay were significantly longer in those who required therapeutic interventions than those without interventions (12 vs 3, 31 vs 10, 17 vs 8, and 60 vs 43 days, respectively, P < 0.05).Conclusion: Pleural effusion following pediatric LT is common and its potential risk factor is PELD score at LT ≥ 18. Post-LT pleural effusion is associated with prolonged oxygen dependence time, ICU stay and hospital stay, particularly those who required therapeutic interventions.Keywords: pleural effusion, pediatric liver transplantation, liver transplantation, post-liver transplant pleural effusion, pulmonary complicationsThirapattaraphan CSrina PBoonthai AArpornsujaritkun NSakulchairungrueng BApinyachon WTreepongkaruna SDove Medical Pressarticlepleural effusionpediatric liver transplantationliver transplantationpost-liver transplant pleural effusionpulmonary complicationsMedicine (General)R5-920ENTransplant Research and Risk Management, Vol Volume 12, Pp 29-35 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	pleural effusion pediatric liver transplantation liver transplantation post-liver transplant pleural effusion pulmonary complications Medicine (General) R5-920
spellingShingle	pleural effusion pediatric liver transplantation liver transplantation post-liver transplant pleural effusion pulmonary complications Medicine (General) R5-920 Thirapattaraphan C Srina P Boonthai A Arpornsujaritkun N Sakulchairungrueng B Apinyachon W Treepongkaruna S Risk Factors of Pleural Effusion Following Pediatric Liver Transplantation and the Perioperative Outcomes
description	Chollasak Thirapattaraphan,1,2 Prapatsorn Srina,1 Ampaipan Boonthai,1,2 Nuttapon Arpornsujaritkun,2,3 Bundit Sakulchairungrueng,2,3 Worapot Apinyachon,2,4 Suporn Treepongkaruna2,5 1Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Ramathibodi Excellent Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Division of Vascular Surgery and Transplantation, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 4Department of Anesthesiology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 5Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Suporn TreepongkarunaDivision of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok 10400, ThailandTel/Fax +6622011446Email suporntr@gmail.comBackground: Pediatric liver transplantation (LT) has been accepted as a definitive treatment for end-stage liver disease. Pleural effusion is a common pulmonary complication following LT in children. The objectives of the study were to identify prevalence of post-LT pleural effusion, risk factors, and the impact on patients’ outcomes.Methods: A retrospective study was conducted in 107 pediatric patients who underwent LT at our center between March 2001 and June 2018. They were categorized into pleural effusion and non-pleural effusion groups. Preoperative and perioperative data, intraoperative findings, liver graft characteristics, and perioperative outcomes were compared between the two groups.Results: Post-LT pleural effusion occurred in 64 (59.8%) patients. There were more patients with PELD score ≥ 18 in the pleural effusion group (68.8 vs 48.8%, P=0.039). Other preoperative and perioperative data were not significantly different. The pleural effusion group had a higher rate of reoperation than non-pleural effusion group (55.6 vs 30.9%, P=0.013). Median oxygen dependence time, length of ICU and hospital stay were significantly longer in the pleural effusion group (18.5 vs 7.0, 10 vs 7 and 48 vs 34 days, respectively, P < 0.05). However, mortality was not significantly different. Among the patients with pleural effusion, median time to extubation, oxygen dependence time, length of ICU and hospital stay were significantly longer in those who required therapeutic interventions than those without interventions (12 vs 3, 31 vs 10, 17 vs 8, and 60 vs 43 days, respectively, P < 0.05).Conclusion: Pleural effusion following pediatric LT is common and its potential risk factor is PELD score at LT ≥ 18. Post-LT pleural effusion is associated with prolonged oxygen dependence time, ICU stay and hospital stay, particularly those who required therapeutic interventions.Keywords: pleural effusion, pediatric liver transplantation, liver transplantation, post-liver transplant pleural effusion, pulmonary complications
format	article
author	Thirapattaraphan C Srina P Boonthai A Arpornsujaritkun N Sakulchairungrueng B Apinyachon W Treepongkaruna S
author_facet	Thirapattaraphan C Srina P Boonthai A Arpornsujaritkun N Sakulchairungrueng B Apinyachon W Treepongkaruna S
author_sort	Thirapattaraphan C
title	Risk Factors of Pleural Effusion Following Pediatric Liver Transplantation and the Perioperative Outcomes
title_short	Risk Factors of Pleural Effusion Following Pediatric Liver Transplantation and the Perioperative Outcomes
title_full	Risk Factors of Pleural Effusion Following Pediatric Liver Transplantation and the Perioperative Outcomes
title_fullStr	Risk Factors of Pleural Effusion Following Pediatric Liver Transplantation and the Perioperative Outcomes
title_full_unstemmed	Risk Factors of Pleural Effusion Following Pediatric Liver Transplantation and the Perioperative Outcomes
title_sort	risk factors of pleural effusion following pediatric liver transplantation and the perioperative outcomes
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/8c7d5a4206e64ad488e0dfb645cd8d5e
work_keys_str_mv	AT thirapattaraphanc riskfactorsofpleuraleffusionfollowingpediatriclivertransplantationandtheperioperativeoutcomes AT srinap riskfactorsofpleuraleffusionfollowingpediatriclivertransplantationandtheperioperativeoutcomes AT boonthaia riskfactorsofpleuraleffusionfollowingpediatriclivertransplantationandtheperioperativeoutcomes AT arpornsujaritkunn riskfactorsofpleuraleffusionfollowingpediatriclivertransplantationandtheperioperativeoutcomes AT sakulchairungruengb riskfactorsofpleuraleffusionfollowingpediatriclivertransplantationandtheperioperativeoutcomes AT apinyachonw riskfactorsofpleuraleffusionfollowingpediatriclivertransplantationandtheperioperativeoutcomes AT treepongkarunas riskfactorsofpleuraleffusionfollowingpediatriclivertransplantationandtheperioperativeoutcomes
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Risk Factors of Pleural Effusion Following Pediatric Liver Transplantation and the Perioperative Outcomes

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