Luciferase-induced photoreductive uncaging of small-molecule effectors

Bioluminescence resonance energy transfer (BRET) has been mostly employed in imaging applications. Here the authors use BRET to activate a ruthenium-based photocatalyst and perform a bioorthogonal chemical reaction, which can be used to uncage small molecule drugs in a cellular context.

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Autores principales:	Eric Lindberg, Simona Angerani, Marcello Anzola, Nicolas Winssinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c819437d8e744dbb7cd4be87488f8b1
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spelling	oai:doaj.org-article:8c819437d8e744dbb7cd4be87488f8b12021-12-02T17:32:32ZLuciferase-induced photoreductive uncaging of small-molecule effectors10.1038/s41467-018-05916-92041-1723https://doaj.org/article/8c819437d8e744dbb7cd4be87488f8b12018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05916-9https://doaj.org/toc/2041-1723Bioluminescence resonance energy transfer (BRET) has been mostly employed in imaging applications. Here the authors use BRET to activate a ruthenium-based photocatalyst and perform a bioorthogonal chemical reaction, which can be used to uncage small molecule drugs in a cellular context.Eric LindbergSimona AngeraniMarcello AnzolaNicolas WinssingerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eric Lindberg Simona Angerani Marcello Anzola Nicolas Winssinger Luciferase-induced photoreductive uncaging of small-molecule effectors
description	Bioluminescence resonance energy transfer (BRET) has been mostly employed in imaging applications. Here the authors use BRET to activate a ruthenium-based photocatalyst and perform a bioorthogonal chemical reaction, which can be used to uncage small molecule drugs in a cellular context.
format	article
author	Eric Lindberg Simona Angerani Marcello Anzola Nicolas Winssinger
author_facet	Eric Lindberg Simona Angerani Marcello Anzola Nicolas Winssinger
author_sort	Eric Lindberg
title	Luciferase-induced photoreductive uncaging of small-molecule effectors
title_short	Luciferase-induced photoreductive uncaging of small-molecule effectors
title_full	Luciferase-induced photoreductive uncaging of small-molecule effectors
title_fullStr	Luciferase-induced photoreductive uncaging of small-molecule effectors
title_full_unstemmed	Luciferase-induced photoreductive uncaging of small-molecule effectors
title_sort	luciferase-induced photoreductive uncaging of small-molecule effectors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8c819437d8e744dbb7cd4be87488f8b1
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Luciferase-induced photoreductive uncaging of small-molecule effectors

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