Structural basis of human PCNA sliding on DNA

DNA sliding clamps are ring-shaped proteins that encircle DNA and harbour polymerases and other factors that promote processive DNA replication. Here the authors use X-ray crystallography, NMR and MD simulations to propose a model for a PCNA sliding mechanism that relies on short-lived polar interac...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Matteo De March, Nekane Merino, Susana Barrera-Vilarmau, Ramon Crehuet, Silvia Onesti, Francisco J. Blanco, Alfredo De Biasio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c85d2e68cfb4c3dbfb88a6096a853d2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8c85d2e68cfb4c3dbfb88a6096a853d2
record_format	dspace
spelling	oai:doaj.org-article:8c85d2e68cfb4c3dbfb88a6096a853d22021-12-02T14:41:19ZStructural basis of human PCNA sliding on DNA10.1038/ncomms139352041-1723https://doaj.org/article/8c85d2e68cfb4c3dbfb88a6096a853d22017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13935https://doaj.org/toc/2041-1723DNA sliding clamps are ring-shaped proteins that encircle DNA and harbour polymerases and other factors that promote processive DNA replication. Here the authors use X-ray crystallography, NMR and MD simulations to propose a model for a PCNA sliding mechanism that relies on short-lived polar interactions.Matteo De MarchNekane MerinoSusana Barrera-VilarmauRamon CrehuetSilvia OnestiFrancisco J. BlancoAlfredo De BiasioNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matteo De March Nekane Merino Susana Barrera-Vilarmau Ramon Crehuet Silvia Onesti Francisco J. Blanco Alfredo De Biasio Structural basis of human PCNA sliding on DNA
description	DNA sliding clamps are ring-shaped proteins that encircle DNA and harbour polymerases and other factors that promote processive DNA replication. Here the authors use X-ray crystallography, NMR and MD simulations to propose a model for a PCNA sliding mechanism that relies on short-lived polar interactions.
format	article
author	Matteo De March Nekane Merino Susana Barrera-Vilarmau Ramon Crehuet Silvia Onesti Francisco J. Blanco Alfredo De Biasio
author_facet	Matteo De March Nekane Merino Susana Barrera-Vilarmau Ramon Crehuet Silvia Onesti Francisco J. Blanco Alfredo De Biasio
author_sort	Matteo De March
title	Structural basis of human PCNA sliding on DNA
title_short	Structural basis of human PCNA sliding on DNA
title_full	Structural basis of human PCNA sliding on DNA
title_fullStr	Structural basis of human PCNA sliding on DNA
title_full_unstemmed	Structural basis of human PCNA sliding on DNA
title_sort	structural basis of human pcna sliding on dna
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8c85d2e68cfb4c3dbfb88a6096a853d2
work_keys_str_mv	AT matteodemarch structuralbasisofhumanpcnaslidingondna AT nekanemerino structuralbasisofhumanpcnaslidingondna AT susanabarreravilarmau structuralbasisofhumanpcnaslidingondna AT ramoncrehuet structuralbasisofhumanpcnaslidingondna AT silviaonesti structuralbasisofhumanpcnaslidingondna AT franciscojblanco structuralbasisofhumanpcnaslidingondna AT alfredodebiasio structuralbasisofhumanpcnaslidingondna
_version_	1718389943260151808

Structural basis of human PCNA sliding on DNA

Ejemplares similares