Catechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity.

<h4>Background</h4>Muscle strength declines on average by one percent annually from midlife on. In postmenopausal women this decrement coincides with a rapid decline in estrogen production. The genetics underlying the effects of estrogen on skeletal muscle remains unclear. In the present...

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Autores principales:	Paula H A Ronkainen, Eija Pöllänen, Timo Törmäkangas, Kristina Tiainen, Markku Koskenvuo, Jaakko Kaprio, Taina Rantanen, Sarianna Sipilä, Vuokko Kovanen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c85faed835f4ca288dbb474d8c759ca
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spelling	oai:doaj.org-article:8c85faed835f4ca288dbb474d8c759ca2021-11-25T06:13:02ZCatechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity.1932-620310.1371/journal.pone.0001819https://doaj.org/article/8c85faed835f4ca288dbb474d8c759ca2008-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18350156/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Muscle strength declines on average by one percent annually from midlife on. In postmenopausal women this decrement coincides with a rapid decline in estrogen production. The genetics underlying the effects of estrogen on skeletal muscle remains unclear. In the present study, we examined whether polymorphisms within COMT and ESR1 are associated with muscle properties and assessed their interaction and their combined effects with physical activity.<h4>Methodology/principal findings</h4>A cross-sectional data analysis was conducted with 434 63-76-year-old women from the population-based Finnish Twin Study on Aging. Body anthropometry, muscle cross-sectional area (mCSA), isometric hand grip and knee extension strengths, and leg extension power were measured. COMT Val158Met and ESR1 PvuII genotypes were determined by the RFLP method. mCSA differed by COMT genotypes (p = 0.014) being significantly larger in LL than HL individuals in unadjusted (p = 0.001) and age- and height-adjusted model (p = 0.004). When physical activity and age were entered into GEE model, COMT genotype had a significant main effect (p = 0.038) on mCSA. Furthermore, sedentary individuals with the HH genotype had lower muscle mass, strength and power, but they also appeared to benefit the most from physical activity. No association of ESR1 PvuII polymorphism with any of the muscle outcomes was observed.<h4>Conclusions/significance</h4>The present study suggests that the COMT polymorphism, affecting the activity of the enzyme, is associated with muscle mass. Furthermore, sedentary individuals with potential high enzyme activity were the weakest group, but they may potentially benefit the most from physical activity. This observation elucidates the importance of both environmental and genetic factors in muscle properties.Paula H A RonkainenEija PöllänenTimo TörmäkangasKristina TiainenMarkku KoskenvuoJaakko KaprioTaina RantanenSarianna SipiläVuokko KovanenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 3, p e1819 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paula H A Ronkainen Eija Pöllänen Timo Törmäkangas Kristina Tiainen Markku Koskenvuo Jaakko Kaprio Taina Rantanen Sarianna Sipilä Vuokko Kovanen Catechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity.
description	<h4>Background</h4>Muscle strength declines on average by one percent annually from midlife on. In postmenopausal women this decrement coincides with a rapid decline in estrogen production. The genetics underlying the effects of estrogen on skeletal muscle remains unclear. In the present study, we examined whether polymorphisms within COMT and ESR1 are associated with muscle properties and assessed their interaction and their combined effects with physical activity.<h4>Methodology/principal findings</h4>A cross-sectional data analysis was conducted with 434 63-76-year-old women from the population-based Finnish Twin Study on Aging. Body anthropometry, muscle cross-sectional area (mCSA), isometric hand grip and knee extension strengths, and leg extension power were measured. COMT Val158Met and ESR1 PvuII genotypes were determined by the RFLP method. mCSA differed by COMT genotypes (p = 0.014) being significantly larger in LL than HL individuals in unadjusted (p = 0.001) and age- and height-adjusted model (p = 0.004). When physical activity and age were entered into GEE model, COMT genotype had a significant main effect (p = 0.038) on mCSA. Furthermore, sedentary individuals with the HH genotype had lower muscle mass, strength and power, but they also appeared to benefit the most from physical activity. No association of ESR1 PvuII polymorphism with any of the muscle outcomes was observed.<h4>Conclusions/significance</h4>The present study suggests that the COMT polymorphism, affecting the activity of the enzyme, is associated with muscle mass. Furthermore, sedentary individuals with potential high enzyme activity were the weakest group, but they may potentially benefit the most from physical activity. This observation elucidates the importance of both environmental and genetic factors in muscle properties.
format	article
author	Paula H A Ronkainen Eija Pöllänen Timo Törmäkangas Kristina Tiainen Markku Koskenvuo Jaakko Kaprio Taina Rantanen Sarianna Sipilä Vuokko Kovanen
author_facet	Paula H A Ronkainen Eija Pöllänen Timo Törmäkangas Kristina Tiainen Markku Koskenvuo Jaakko Kaprio Taina Rantanen Sarianna Sipilä Vuokko Kovanen
author_sort	Paula H A Ronkainen
title	Catechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity.
title_short	Catechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity.
title_full	Catechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity.
title_fullStr	Catechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity.
title_full_unstemmed	Catechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity.
title_sort	catechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/8c85faed835f4ca288dbb474d8c759ca
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Catechol-o-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity.

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