Mycophenolate mofetil for myasthenia gravis: a clear and present controversy
Chad Heatwole, Emma CiafaloniDepartment of Neurology, The University of Rochester, Rochester, New York, USAAbstract: Mycophenolate mofetil (MMF) has been used to treat myasthenia gravis (MG) for over 10 years. MMF’s use in the MG population stems from its theoretical mechanism of actio...
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Dove Medical Press
2008
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oai:doaj.org-article:8c86069ab9fb4db2873d6c827b7de2e22021-12-02T05:34:45ZMycophenolate mofetil for myasthenia gravis: a clear and present controversy1176-63281178-2021https://doaj.org/article/8c86069ab9fb4db2873d6c827b7de2e22008-11-01T00:00:00Zhttp://www.dovepress.com/mycophenolate-mofetil-for-myasthenia-gravis-a-clear-and-present-contro-a2548https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Chad Heatwole, Emma CiafaloniDepartment of Neurology, The University of Rochester, Rochester, New York, USAAbstract: Mycophenolate mofetil (MMF) has been used to treat myasthenia gravis (MG) for over 10 years. MMF’s use in the MG population stems from its theoretical mechanism of action and the medical literature that supports its benefit in MG patients. Recently, two large, double-blinded, placebo-controlled, randomized clinical trials were initiated to study the effectiveness of MMF for MG. One of these studies found no benefit in taking MMF with 20 mg of prednisone as compared to taking prednisone alone, while the other study demonstrated no advantage in taking MMF against placebo during a 36-week prednisone taper. This article critically reviews the medical literature on MMF’s use in MG and suggests further research avenues on this topic.Keywords: myasthenia gravis, mycophenolate mofetil, CellCept Chad HeatwoleEmma CiafaloniDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 6, Pp 1203-1209 (2008) |
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DOAJ |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chad Heatwole Emma Ciafaloni Mycophenolate mofetil for myasthenia gravis: a clear and present controversy |
| description |
Chad Heatwole, Emma CiafaloniDepartment of Neurology, The University of Rochester, Rochester, New York, USAAbstract: Mycophenolate mofetil (MMF) has been used to treat myasthenia gravis (MG) for over 10 years. MMF’s use in the MG population stems from its theoretical mechanism of action and the medical literature that supports its benefit in MG patients. Recently, two large, double-blinded, placebo-controlled, randomized clinical trials were initiated to study the effectiveness of MMF for MG. One of these studies found no benefit in taking MMF with 20 mg of prednisone as compared to taking prednisone alone, while the other study demonstrated no advantage in taking MMF against placebo during a 36-week prednisone taper. This article critically reviews the medical literature on MMF’s use in MG and suggests further research avenues on this topic.Keywords: myasthenia gravis, mycophenolate mofetil, CellCept |
| format |
article |
| author |
Chad Heatwole Emma Ciafaloni |
| author_facet |
Chad Heatwole Emma Ciafaloni |
| author_sort |
Chad Heatwole |
| title |
Mycophenolate mofetil for myasthenia gravis: a clear and present controversy |
| title_short |
Mycophenolate mofetil for myasthenia gravis: a clear and present controversy |
| title_full |
Mycophenolate mofetil for myasthenia gravis: a clear and present controversy |
| title_fullStr |
Mycophenolate mofetil for myasthenia gravis: a clear and present controversy |
| title_full_unstemmed |
Mycophenolate mofetil for myasthenia gravis: a clear and present controversy |
| title_sort |
mycophenolate mofetil for myasthenia gravis: a clear and present controversy |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/8c86069ab9fb4db2873d6c827b7de2e2 |
| work_keys_str_mv |
AT chadheatwole mycophenolatemofetilformyastheniagravisaclearandpresentcontroversy AT emmaciafaloni mycophenolatemofetilformyastheniagravisaclearandpresentcontroversy |
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1718400362837180416 |