In Vivo Investigation of Soft Tissue Response of Novel Silver/Poly(Vinyl Alcohol)/ Graphene and Silver/Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Aimed for Medical Applications – The First Experience

In this paper, we have shown for the fi rst time the soft tissue response of novel silver/ poly(vinyl alcohol)/graphene (Ag/PVA/Gr) and silver/poly(vinyl alcohol)/chitosan/ graphene (Ag/PVA/CHI/Gr) nanocomposite hydrogels aimed for medical applications. These novel hydrogels were produced by in situ...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lužajić Božinovski Tijana1, Marković Danica, Todorović Vera, Prokić Bolka Bogomir, Milošević Ivan, Drndarević Neda, Nešović Katarina, Kyong Yop Rhee, Mišković-Stanković Vesna
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	biocompatibility nanocomposite hydrogels rat soft tissue response Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/8c86aec0d6b44b648072e86be5db5db4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8c86aec0d6b44b648072e86be5db5db4
record_format	dspace
spelling	oai:doaj.org-article:8c86aec0d6b44b648072e86be5db5db42021-11-17T21:27:53ZIn Vivo Investigation of Soft Tissue Response of Novel Silver/Poly(Vinyl Alcohol)/ Graphene and Silver/Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Aimed for Medical Applications – The First Experience1820-744810.2478/acve-2018-0027https://doaj.org/article/8c86aec0d6b44b648072e86be5db5db42018-09-01T00:00:00Zhttps://doi.org/10.2478/acve-2018-0027https://doaj.org/toc/1820-7448In this paper, we have shown for the fi rst time the soft tissue response of novel silver/ poly(vinyl alcohol)/graphene (Ag/PVA/Gr) and silver/poly(vinyl alcohol)/chitosan/ graphene (Ag/PVA/CHI/Gr) nanocomposite hydrogels aimed for medical applications. These novel hydrogels were produced by in situ electrochemical synthesis of silver nanoparticles in the polymer matrices as described in our previously published works. Both Ag/PVA/Gr and Ag/PVA/CHI/Gr, as well as controls Ag/PVA, Ag/PVA/CHI and commercial Suprasorb©hydrogel discs, were implanted in the subcutaneous tissue of rats. Implants with the surrounding tissue were dissected after post-implantation on days 7, 15, 30 and 60, and then processed for histological examination. The tissue irritation index (TIrI) score, according to ISO 10993-6, 2007, as well as the number of leukocytes in the peri-implant zone and connective tissue capsule thickness were examined. The results show that each TIrI score, the leukocyte number around the implanted materials and capsule thickness gradually decreased during the observation period. At the endpoint of follow-up, the Ag/PVA/CHI/Gr implant was surrounded with a thinner capsule, while both the TIrI score and the number of leukocytes of the peri-implant zone were greater compared to the Ag/PVA/Gr implant. Despite the observed differences, we can conclude that our in vivo experiment suggested that both novel hydrogels were biocompatible and suitable for medical use.Lužajić Božinovski Tijana1Marković DanicaTodorović VeraProkić Bolka BogomirMilošević IvanDrndarević NedaNešović KatarinaKyong Yop RheeMišković-Stanković VesnaSciendoarticlebiocompatibilitynanocomposite hydrogelsratsoft tissue responseVeterinary medicineSF600-1100ENActa Veterinaria, Vol 68, Iss 3, Pp 321-339 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	biocompatibility nanocomposite hydrogels rat soft tissue response Veterinary medicine SF600-1100
spellingShingle	biocompatibility nanocomposite hydrogels rat soft tissue response Veterinary medicine SF600-1100 Lužajić Božinovski Tijana1 Marković Danica Todorović Vera Prokić Bolka Bogomir Milošević Ivan Drndarević Neda Nešović Katarina Kyong Yop Rhee Mišković-Stanković Vesna In Vivo Investigation of Soft Tissue Response of Novel Silver/Poly(Vinyl Alcohol)/ Graphene and Silver/Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Aimed for Medical Applications – The First Experience
description	In this paper, we have shown for the fi rst time the soft tissue response of novel silver/ poly(vinyl alcohol)/graphene (Ag/PVA/Gr) and silver/poly(vinyl alcohol)/chitosan/ graphene (Ag/PVA/CHI/Gr) nanocomposite hydrogels aimed for medical applications. These novel hydrogels were produced by in situ electrochemical synthesis of silver nanoparticles in the polymer matrices as described in our previously published works. Both Ag/PVA/Gr and Ag/PVA/CHI/Gr, as well as controls Ag/PVA, Ag/PVA/CHI and commercial Suprasorb©hydrogel discs, were implanted in the subcutaneous tissue of rats. Implants with the surrounding tissue were dissected after post-implantation on days 7, 15, 30 and 60, and then processed for histological examination. The tissue irritation index (TIrI) score, according to ISO 10993-6, 2007, as well as the number of leukocytes in the peri-implant zone and connective tissue capsule thickness were examined. The results show that each TIrI score, the leukocyte number around the implanted materials and capsule thickness gradually decreased during the observation period. At the endpoint of follow-up, the Ag/PVA/CHI/Gr implant was surrounded with a thinner capsule, while both the TIrI score and the number of leukocytes of the peri-implant zone were greater compared to the Ag/PVA/Gr implant. Despite the observed differences, we can conclude that our in vivo experiment suggested that both novel hydrogels were biocompatible and suitable for medical use.
format	article
author	Lužajić Božinovski Tijana1 Marković Danica Todorović Vera Prokić Bolka Bogomir Milošević Ivan Drndarević Neda Nešović Katarina Kyong Yop Rhee Mišković-Stanković Vesna
author_facet	Lužajić Božinovski Tijana1 Marković Danica Todorović Vera Prokić Bolka Bogomir Milošević Ivan Drndarević Neda Nešović Katarina Kyong Yop Rhee Mišković-Stanković Vesna
author_sort	Lužajić Božinovski Tijana1
title	In Vivo Investigation of Soft Tissue Response of Novel Silver/Poly(Vinyl Alcohol)/ Graphene and Silver/Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Aimed for Medical Applications – The First Experience
title_short	In Vivo Investigation of Soft Tissue Response of Novel Silver/Poly(Vinyl Alcohol)/ Graphene and Silver/Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Aimed for Medical Applications – The First Experience
title_full	In Vivo Investigation of Soft Tissue Response of Novel Silver/Poly(Vinyl Alcohol)/ Graphene and Silver/Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Aimed for Medical Applications – The First Experience
title_fullStr	In Vivo Investigation of Soft Tissue Response of Novel Silver/Poly(Vinyl Alcohol)/ Graphene and Silver/Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Aimed for Medical Applications – The First Experience
title_full_unstemmed	In Vivo Investigation of Soft Tissue Response of Novel Silver/Poly(Vinyl Alcohol)/ Graphene and Silver/Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Aimed for Medical Applications – The First Experience
title_sort	in vivo investigation of soft tissue response of novel silver/poly(vinyl alcohol)/ graphene and silver/poly(vinyl alcohol)/chitosan/graphene hydrogels aimed for medical applications – the first experience
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/8c86aec0d6b44b648072e86be5db5db4
work_keys_str_mv	AT luzajicbozinovskitijana1 invivoinvestigationofsofttissueresponseofnovelsilverpolyvinylalcoholgrapheneandsilverpolyvinylalcoholchitosangraphenehydrogelsaimedformedicalapplicationsthefirstexperience AT markovicdanica invivoinvestigationofsofttissueresponseofnovelsilverpolyvinylalcoholgrapheneandsilverpolyvinylalcoholchitosangraphenehydrogelsaimedformedicalapplicationsthefirstexperience AT todorovicvera invivoinvestigationofsofttissueresponseofnovelsilverpolyvinylalcoholgrapheneandsilverpolyvinylalcoholchitosangraphenehydrogelsaimedformedicalapplicationsthefirstexperience AT prokicbolkabogomir invivoinvestigationofsofttissueresponseofnovelsilverpolyvinylalcoholgrapheneandsilverpolyvinylalcoholchitosangraphenehydrogelsaimedformedicalapplicationsthefirstexperience AT milosevicivan invivoinvestigationofsofttissueresponseofnovelsilverpolyvinylalcoholgrapheneandsilverpolyvinylalcoholchitosangraphenehydrogelsaimedformedicalapplicationsthefirstexperience AT drndarevicneda invivoinvestigationofsofttissueresponseofnovelsilverpolyvinylalcoholgrapheneandsilverpolyvinylalcoholchitosangraphenehydrogelsaimedformedicalapplicationsthefirstexperience AT nesovickatarina invivoinvestigationofsofttissueresponseofnovelsilverpolyvinylalcoholgrapheneandsilverpolyvinylalcoholchitosangraphenehydrogelsaimedformedicalapplicationsthefirstexperience AT kyongyoprhee invivoinvestigationofsofttissueresponseofnovelsilverpolyvinylalcoholgrapheneandsilverpolyvinylalcoholchitosangraphenehydrogelsaimedformedicalapplicationsthefirstexperience AT miskovicstankovicvesna invivoinvestigationofsofttissueresponseofnovelsilverpolyvinylalcoholgrapheneandsilverpolyvinylalcoholchitosangraphenehydrogelsaimedformedicalapplicationsthefirstexperience
_version_	1718425297205854208

In Vivo Investigation of Soft Tissue Response of Novel Silver/Poly(Vinyl Alcohol)/ Graphene and Silver/Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Aimed for Medical Applications – The First Experience

Ejemplares similares