Exploring new roles for actin upon LTP induction in dendritic spines

Abstract Dendritic spines, small protrusions of the dendrites, enlarge upon LTP induction, linking morphological and functional properties. Although the role of actin in spine enlargement has been well studied, little is known about its relationship with mechanical membrane properties, such as membr...

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Autores principales:	Mayte Bonilla-Quintana, Florentin Wörgötter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c8daf2f2de84a8bab2b7137daf5456e
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spelling	oai:doaj.org-article:8c8daf2f2de84a8bab2b7137daf5456e2021-12-02T14:23:23ZExploring new roles for actin upon LTP induction in dendritic spines10.1038/s41598-021-86367-z2045-2322https://doaj.org/article/8c8daf2f2de84a8bab2b7137daf5456e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86367-zhttps://doaj.org/toc/2045-2322Abstract Dendritic spines, small protrusions of the dendrites, enlarge upon LTP induction, linking morphological and functional properties. Although the role of actin in spine enlargement has been well studied, little is known about its relationship with mechanical membrane properties, such as membrane tension, which is involved in many cell processes, like exocytosis. Here, we use a 3D model of the dendritic spine to investigate how polymerization of actin filaments can effectively elevate the membrane tension to trigger exocytosis in a domain close to the tip of the spine. Moreover, we show that the same pool of actin promotes full membrane fusion after exocytosis and spine stabilization.Mayte Bonilla-QuintanaFlorentin WörgötterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mayte Bonilla-Quintana Florentin Wörgötter Exploring new roles for actin upon LTP induction in dendritic spines
description	Abstract Dendritic spines, small protrusions of the dendrites, enlarge upon LTP induction, linking morphological and functional properties. Although the role of actin in spine enlargement has been well studied, little is known about its relationship with mechanical membrane properties, such as membrane tension, which is involved in many cell processes, like exocytosis. Here, we use a 3D model of the dendritic spine to investigate how polymerization of actin filaments can effectively elevate the membrane tension to trigger exocytosis in a domain close to the tip of the spine. Moreover, we show that the same pool of actin promotes full membrane fusion after exocytosis and spine stabilization.
format	article
author	Mayte Bonilla-Quintana Florentin Wörgötter
author_facet	Mayte Bonilla-Quintana Florentin Wörgötter
author_sort	Mayte Bonilla-Quintana
title	Exploring new roles for actin upon LTP induction in dendritic spines
title_short	Exploring new roles for actin upon LTP induction in dendritic spines
title_full	Exploring new roles for actin upon LTP induction in dendritic spines
title_fullStr	Exploring new roles for actin upon LTP induction in dendritic spines
title_full_unstemmed	Exploring new roles for actin upon LTP induction in dendritic spines
title_sort	exploring new roles for actin upon ltp induction in dendritic spines
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8c8daf2f2de84a8bab2b7137daf5456e
work_keys_str_mv	AT maytebonillaquintana exploringnewrolesforactinuponltpinductionindendriticspines AT florentinworgotter exploringnewrolesforactinuponltpinductionindendriticspines
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Exploring new roles for actin upon LTP induction in dendritic spines

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