Multi-drug-resistance in newly identified patients with tuberculosis in the Sakha Republic (Yakutia)

Epidemiological process of tuberculosis (TB) in the Sakha Republic (Yakutia) has been characterized by growing incidence of M. tuberculosis (MTB) multidrug-resistance (MDR). This study aimed to explore the incidence of primary MDR in patients with pulmonary TBin Yakutia from 2011 to 2016. Rates of p...

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Autores principales:	L. P. Yakovleva, S. N. Kondakov, O. D. Kondratieva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	tuberculosis of respiratory organs incidence rate of tuberculosis bacterial excretion mycobacterium tuberculosis multiple drug resistance Science Q
Acceso en línea:	https://doaj.org/article/8c9401ddc18e478e827360b0f4c984eb
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spelling	oai:doaj.org-article:8c9401ddc18e478e827360b0f4c984eb2021-11-23T06:14:40ZMulti-drug-resistance in newly identified patients with tuberculosis in the Sakha Republic (Yakutia)2541-94202587-959610.29413/ABS.2018-3.2.14https://doaj.org/article/8c9401ddc18e478e827360b0f4c984eb2018-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/564https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Epidemiological process of tuberculosis (TB) in the Sakha Republic (Yakutia) has been characterized by growing incidence of M. tuberculosis (MTB) multidrug-resistance (MDR). This study aimed to explore the incidence of primary MDR in patients with pulmonary TBin Yakutia from 2011 to 2016. Rates of primary MDR (including extensively drug resistant (XDR) cases) incidence were analyzed in new patients with sputum- and/or culture-positive pulmonary TB for Yakutia, Yakutsk, rural regions of Yakutia, and 5 major territorial zones of Yakutia, through theyears 2011 to 2016. We observed an increase from 23 % to 25 % in the proportion of pulmonary TB among primary MDR cases in Yakutia, for the study period. In 2016, this proportion was 1.1 times higher than in Russia (23.4 %), but lower than in the Far East Federal District (25.7 %). In Yakutsk, the same proportion has increased by half (from 24.2 to 35.4 %); in rural regions, on the contrary, it decreased by half (from 21.9 to 14.9 %). Primary MDR percentages among new cases of pulmonary TB decreased in South Yakutia and West Yakutia zones (by factors of 6.7 and 1.6, respectively); same proportions in the Arctic and Central Yakutia zones changed insignificantly. In East Yakutia zone, no case of primary MdR was detected in 2016. XDR cases among new pulmonary TB cases were solitary in 2011, detected only in Yakutsk. During the study period, incidence of XDR among new pulmonary TB cases increased from 0.5 % to 1.7 %, and cases with primary XDR were detected in Yakutsk and Arctic zone.L. P. YakovlevaS. N. KondakovO. D. KondratievaScientific Сentre for Family Health and Human Reproduction Problemsarticletuberculosis of respiratory organsincidence rate of tuberculosisbacterial excretionmycobacterium tuberculosismultiple drug resistanceScienceQRUActa Biomedica Scientifica, Vol 3, Iss 2, Pp 80-84 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis of respiratory organs incidence rate of tuberculosis bacterial excretion mycobacterium tuberculosis multiple drug resistance Science Q
spellingShingle	tuberculosis of respiratory organs incidence rate of tuberculosis bacterial excretion mycobacterium tuberculosis multiple drug resistance Science Q L. P. Yakovleva S. N. Kondakov O. D. Kondratieva Multi-drug-resistance in newly identified patients with tuberculosis in the Sakha Republic (Yakutia)
description	Epidemiological process of tuberculosis (TB) in the Sakha Republic (Yakutia) has been characterized by growing incidence of M. tuberculosis (MTB) multidrug-resistance (MDR). This study aimed to explore the incidence of primary MDR in patients with pulmonary TBin Yakutia from 2011 to 2016. Rates of primary MDR (including extensively drug resistant (XDR) cases) incidence were analyzed in new patients with sputum- and/or culture-positive pulmonary TB for Yakutia, Yakutsk, rural regions of Yakutia, and 5 major territorial zones of Yakutia, through theyears 2011 to 2016. We observed an increase from 23 % to 25 % in the proportion of pulmonary TB among primary MDR cases in Yakutia, for the study period. In 2016, this proportion was 1.1 times higher than in Russia (23.4 %), but lower than in the Far East Federal District (25.7 %). In Yakutsk, the same proportion has increased by half (from 24.2 to 35.4 %); in rural regions, on the contrary, it decreased by half (from 21.9 to 14.9 %). Primary MDR percentages among new cases of pulmonary TB decreased in South Yakutia and West Yakutia zones (by factors of 6.7 and 1.6, respectively); same proportions in the Arctic and Central Yakutia zones changed insignificantly. In East Yakutia zone, no case of primary MdR was detected in 2016. XDR cases among new pulmonary TB cases were solitary in 2011, detected only in Yakutsk. During the study period, incidence of XDR among new pulmonary TB cases increased from 0.5 % to 1.7 %, and cases with primary XDR were detected in Yakutsk and Arctic zone.
format	article
author	L. P. Yakovleva S. N. Kondakov O. D. Kondratieva
author_facet	L. P. Yakovleva S. N. Kondakov O. D. Kondratieva
author_sort	L. P. Yakovleva
title	Multi-drug-resistance in newly identified patients with tuberculosis in the Sakha Republic (Yakutia)
title_short	Multi-drug-resistance in newly identified patients with tuberculosis in the Sakha Republic (Yakutia)
title_full	Multi-drug-resistance in newly identified patients with tuberculosis in the Sakha Republic (Yakutia)
title_fullStr	Multi-drug-resistance in newly identified patients with tuberculosis in the Sakha Republic (Yakutia)
title_full_unstemmed	Multi-drug-resistance in newly identified patients with tuberculosis in the Sakha Republic (Yakutia)
title_sort	multi-drug-resistance in newly identified patients with tuberculosis in the sakha republic (yakutia)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/8c9401ddc18e478e827360b0f4c984eb
work_keys_str_mv	AT lpyakovleva multidrugresistanceinnewlyidentifiedpatientswithtuberculosisinthesakharepublicyakutia AT snkondakov multidrugresistanceinnewlyidentifiedpatientswithtuberculosisinthesakharepublicyakutia AT odkondratieva multidrugresistanceinnewlyidentifiedpatientswithtuberculosisinthesakharepublicyakutia
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Multi-drug-resistance in newly identified patients with tuberculosis in the Sakha Republic (Yakutia)

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