Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.

The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACE...

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Autores principales: Mariam Jamal-Hanjani, Alan Hackshaw, Yenting Ngai, Jacqueline Shaw, Caroline Dive, Sergio Quezada, Gary Middleton, Elza de Bruin, John Le Quesne, Seema Shafi, Mary Falzon, Stuart Horswell, Fiona Blackhall, Iftekhar Khan, Sam Janes, Marianne Nicolson, David Lawrence, Martin Forster, Dean Fennell, Siow-Ming Lee, Jason Lester, Keith Kerr, Salli Muller, Natasha Iles, Sean Smith, Nirupa Murugaesu, Richard Mitter, Max Salm, Aengus Stuart, Nik Matthews, Haydn Adams, Tanya Ahmad, Richard Attanoos, Jonathan Bennett, Nicolai Juul Birkbak, Richard Booton, Ged Brady, Keith Buchan, Arrigo Capitano, Mahendran Chetty, Mark Cobbold, Philip Crosbie, Helen Davies, Alan Denison, Madhav Djearman, Jacki Goldman, Tom Haswell, Leena Joseph, Malgorzata Kornaszewska, Matthew Krebs, Gerald Langman, Mairead MacKenzie, Joy Millar, Bruno Morgan, Babu Naidu, Daisuke Nonaka, Karl Peggs, Catrin Pritchard, Hardy Remmen, Andrew Rowan, Rajesh Shah, Elaine Smith, Yvonne Summers, Magali Taylor, Selvaraju Veeriah, David Waller, Ben Wilcox, Maggie Wilcox, Ian Woolhouse, Nicholas McGranahan, Charles Swanton
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Publicado: Public Library of Science (PLoS) 2014
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spelling oai:doaj.org-article:8c969701acb64396b9868a4b3806e9e12021-11-25T05:33:03ZTracking genomic cancer evolution for precision medicine: the lung TRACERx study.1544-91731545-788510.1371/journal.pbio.1001906https://doaj.org/article/8c969701acb64396b9868a4b3806e9e12014-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25003521/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.Mariam Jamal-HanjaniAlan HackshawYenting NgaiJacqueline ShawCaroline DiveSergio QuezadaGary MiddletonElza de BruinJohn Le QuesneSeema ShafiMary FalzonStuart HorswellFiona BlackhallIftekhar KhanSam JanesMarianne NicolsonDavid LawrenceMartin ForsterDean FennellSiow-Ming LeeJason LesterKeith KerrSalli MullerNatasha IlesSean SmithNirupa MurugaesuRichard MitterMax SalmAengus StuartNik MatthewsHaydn AdamsTanya AhmadRichard AttanoosJonathan BennettNicolai Juul BirkbakRichard BootonGed BradyKeith BuchanArrigo CapitanoMahendran ChettyMark CobboldPhilip CrosbieHelen DaviesAlan DenisonMadhav DjearmanJacki GoldmanTom HaswellLeena JosephMalgorzata KornaszewskaMatthew KrebsGerald LangmanMairead MacKenzieJoy MillarBruno MorganBabu NaiduDaisuke NonakaKarl PeggsCatrin PritchardHardy RemmenAndrew RowanRajesh ShahElaine SmithYvonne SummersMagali TaylorSelvaraju VeeriahDavid WallerBen WilcoxMaggie WilcoxIan WoolhouseNicholas McGranahanCharles SwantonPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 12, Iss 7, p e1001906 (2014)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Mariam Jamal-Hanjani
Alan Hackshaw
Yenting Ngai
Jacqueline Shaw
Caroline Dive
Sergio Quezada
Gary Middleton
Elza de Bruin
John Le Quesne
Seema Shafi
Mary Falzon
Stuart Horswell
Fiona Blackhall
Iftekhar Khan
Sam Janes
Marianne Nicolson
David Lawrence
Martin Forster
Dean Fennell
Siow-Ming Lee
Jason Lester
Keith Kerr
Salli Muller
Natasha Iles
Sean Smith
Nirupa Murugaesu
Richard Mitter
Max Salm
Aengus Stuart
Nik Matthews
Haydn Adams
Tanya Ahmad
Richard Attanoos
Jonathan Bennett
Nicolai Juul Birkbak
Richard Booton
Ged Brady
Keith Buchan
Arrigo Capitano
Mahendran Chetty
Mark Cobbold
Philip Crosbie
Helen Davies
Alan Denison
Madhav Djearman
Jacki Goldman
Tom Haswell
Leena Joseph
Malgorzata Kornaszewska
Matthew Krebs
Gerald Langman
Mairead MacKenzie
Joy Millar
Bruno Morgan
Babu Naidu
Daisuke Nonaka
Karl Peggs
Catrin Pritchard
Hardy Remmen
Andrew Rowan
Rajesh Shah
Elaine Smith
Yvonne Summers
Magali Taylor
Selvaraju Veeriah
David Waller
Ben Wilcox
Maggie Wilcox
Ian Woolhouse
Nicholas McGranahan
Charles Swanton
Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.
description The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.
format article
author Mariam Jamal-Hanjani
Alan Hackshaw
Yenting Ngai
Jacqueline Shaw
Caroline Dive
Sergio Quezada
Gary Middleton
Elza de Bruin
John Le Quesne
Seema Shafi
Mary Falzon
Stuart Horswell
Fiona Blackhall
Iftekhar Khan
Sam Janes
Marianne Nicolson
David Lawrence
Martin Forster
Dean Fennell
Siow-Ming Lee
Jason Lester
Keith Kerr
Salli Muller
Natasha Iles
Sean Smith
Nirupa Murugaesu
Richard Mitter
Max Salm
Aengus Stuart
Nik Matthews
Haydn Adams
Tanya Ahmad
Richard Attanoos
Jonathan Bennett
Nicolai Juul Birkbak
Richard Booton
Ged Brady
Keith Buchan
Arrigo Capitano
Mahendran Chetty
Mark Cobbold
Philip Crosbie
Helen Davies
Alan Denison
Madhav Djearman
Jacki Goldman
Tom Haswell
Leena Joseph
Malgorzata Kornaszewska
Matthew Krebs
Gerald Langman
Mairead MacKenzie
Joy Millar
Bruno Morgan
Babu Naidu
Daisuke Nonaka
Karl Peggs
Catrin Pritchard
Hardy Remmen
Andrew Rowan
Rajesh Shah
Elaine Smith
Yvonne Summers
Magali Taylor
Selvaraju Veeriah
David Waller
Ben Wilcox
Maggie Wilcox
Ian Woolhouse
Nicholas McGranahan
Charles Swanton
author_facet Mariam Jamal-Hanjani
Alan Hackshaw
Yenting Ngai
Jacqueline Shaw
Caroline Dive
Sergio Quezada
Gary Middleton
Elza de Bruin
John Le Quesne
Seema Shafi
Mary Falzon
Stuart Horswell
Fiona Blackhall
Iftekhar Khan
Sam Janes
Marianne Nicolson
David Lawrence
Martin Forster
Dean Fennell
Siow-Ming Lee
Jason Lester
Keith Kerr
Salli Muller
Natasha Iles
Sean Smith
Nirupa Murugaesu
Richard Mitter
Max Salm
Aengus Stuart
Nik Matthews
Haydn Adams
Tanya Ahmad
Richard Attanoos
Jonathan Bennett
Nicolai Juul Birkbak
Richard Booton
Ged Brady
Keith Buchan
Arrigo Capitano
Mahendran Chetty
Mark Cobbold
Philip Crosbie
Helen Davies
Alan Denison
Madhav Djearman
Jacki Goldman
Tom Haswell
Leena Joseph
Malgorzata Kornaszewska
Matthew Krebs
Gerald Langman
Mairead MacKenzie
Joy Millar
Bruno Morgan
Babu Naidu
Daisuke Nonaka
Karl Peggs
Catrin Pritchard
Hardy Remmen
Andrew Rowan
Rajesh Shah
Elaine Smith
Yvonne Summers
Magali Taylor
Selvaraju Veeriah
David Waller
Ben Wilcox
Maggie Wilcox
Ian Woolhouse
Nicholas McGranahan
Charles Swanton
author_sort Mariam Jamal-Hanjani
title Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.
title_short Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.
title_full Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.
title_fullStr Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.
title_full_unstemmed Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.
title_sort tracking genomic cancer evolution for precision medicine: the lung tracerx study.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/8c969701acb64396b9868a4b3806e9e1
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