Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 and poor outcomes. Here the authors compare the transcriptomes of single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19...

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Autores principales:	Linh T. Bui, Nichelle I. Winters, Mei-I Chung, Chitra Joseph, Austin J. Gutierrez, Arun C. Habermann, Taylor S. Adams, Jonas C. Schupp, Sergio Poli, Lance M. Peter, Chase J. Taylor, Jessica B. Blackburn, Bradley W. Richmond, Andrew G. Nicholson, Doris Rassl, William A. Wallace, Ivan O. Rosas, R. Gisli Jenkins, Naftali Kaminski, Jonathan A. Kropski, Nicholas E. Banovich, Human Cell Atlas Lung Biological Network
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c96b7d10ceb4972b8de290313cf45fb
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spelling	oai:doaj.org-article:8c96b7d10ceb4972b8de290313cf45fb2021-12-02T15:33:05ZChronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity10.1038/s41467-021-24467-02041-1723https://doaj.org/article/8c96b7d10ceb4972b8de290313cf45fb2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24467-0https://doaj.org/toc/2041-1723Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 and poor outcomes. Here the authors compare the transcriptomes of single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in these patients.Linh T. BuiNichelle I. WintersMei-I ChungChitra JosephAustin J. GutierrezArun C. HabermannTaylor S. AdamsJonas C. SchuppSergio PoliLance M. PeterChase J. TaylorJessica B. BlackburnBradley W. RichmondAndrew G. NicholsonDoris RasslWilliam A. WallaceIvan O. RosasR. Gisli JenkinsNaftali KaminskiJonathan A. KropskiNicholas E. BanovichHuman Cell Atlas Lung Biological NetworkNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linh T. Bui Nichelle I. Winters Mei-I Chung Chitra Joseph Austin J. Gutierrez Arun C. Habermann Taylor S. Adams Jonas C. Schupp Sergio Poli Lance M. Peter Chase J. Taylor Jessica B. Blackburn Bradley W. Richmond Andrew G. Nicholson Doris Rassl William A. Wallace Ivan O. Rosas R. Gisli Jenkins Naftali Kaminski Jonathan A. Kropski Nicholas E. Banovich Human Cell Atlas Lung Biological Network Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
description	Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 and poor outcomes. Here the authors compare the transcriptomes of single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in these patients.
format	article
author	Linh T. Bui Nichelle I. Winters Mei-I Chung Chitra Joseph Austin J. Gutierrez Arun C. Habermann Taylor S. Adams Jonas C. Schupp Sergio Poli Lance M. Peter Chase J. Taylor Jessica B. Blackburn Bradley W. Richmond Andrew G. Nicholson Doris Rassl William A. Wallace Ivan O. Rosas R. Gisli Jenkins Naftali Kaminski Jonathan A. Kropski Nicholas E. Banovich Human Cell Atlas Lung Biological Network
author_facet	Linh T. Bui Nichelle I. Winters Mei-I Chung Chitra Joseph Austin J. Gutierrez Arun C. Habermann Taylor S. Adams Jonas C. Schupp Sergio Poli Lance M. Peter Chase J. Taylor Jessica B. Blackburn Bradley W. Richmond Andrew G. Nicholson Doris Rassl William A. Wallace Ivan O. Rosas R. Gisli Jenkins Naftali Kaminski Jonathan A. Kropski Nicholas E. Banovich Human Cell Atlas Lung Biological Network
author_sort	Linh T. Bui
title	Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
title_short	Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
title_full	Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
title_fullStr	Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
title_full_unstemmed	Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity
title_sort	chronic lung diseases are associated with gene expression programs favoring sars-cov-2 entry and severity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8c96b7d10ceb4972b8de290313cf45fb
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Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

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