Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

Disruption of autophagy function in cellular and animal models of tauopathy increases tau aggregation. Here, the authors describe a small-molecule screen to identify compounds that promote autophagy clearance of tau and rescue disease-relevant phenotypes in tauopathy patient-derived neurons.

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Autores principales:	M. Catarina Silva, Ghata A. Nandi, Sharon Tentarelli, Ian K. Gurrell, Tanguy Jamier, Diane Lucente, Bradford C. Dickerson, Dean G. Brown, Nicholas J. Brandon, Stephen J. Haggarty
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c984694d54f4d749b8a1bed03dbaffc
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spelling	oai:doaj.org-article:8c984694d54f4d749b8a1bed03dbaffc2021-12-02T17:14:22ZProlonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons10.1038/s41467-020-16984-12041-1723https://doaj.org/article/8c984694d54f4d749b8a1bed03dbaffc2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16984-1https://doaj.org/toc/2041-1723Disruption of autophagy function in cellular and animal models of tauopathy increases tau aggregation. Here, the authors describe a small-molecule screen to identify compounds that promote autophagy clearance of tau and rescue disease-relevant phenotypes in tauopathy patient-derived neurons.M. Catarina SilvaGhata A. NandiSharon TentarelliIan K. GurrellTanguy JamierDiane LucenteBradford C. DickersonDean G. BrownNicholas J. BrandonStephen J. HaggartyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q M. Catarina Silva Ghata A. Nandi Sharon Tentarelli Ian K. Gurrell Tanguy Jamier Diane Lucente Bradford C. Dickerson Dean G. Brown Nicholas J. Brandon Stephen J. Haggarty Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
description	Disruption of autophagy function in cellular and animal models of tauopathy increases tau aggregation. Here, the authors describe a small-molecule screen to identify compounds that promote autophagy clearance of tau and rescue disease-relevant phenotypes in tauopathy patient-derived neurons.
format	article
author	M. Catarina Silva Ghata A. Nandi Sharon Tentarelli Ian K. Gurrell Tanguy Jamier Diane Lucente Bradford C. Dickerson Dean G. Brown Nicholas J. Brandon Stephen J. Haggarty
author_facet	M. Catarina Silva Ghata A. Nandi Sharon Tentarelli Ian K. Gurrell Tanguy Jamier Diane Lucente Bradford C. Dickerson Dean G. Brown Nicholas J. Brandon Stephen J. Haggarty
author_sort	M. Catarina Silva
title	Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
title_short	Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
title_full	Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
title_fullStr	Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
title_full_unstemmed	Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
title_sort	prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8c984694d54f4d749b8a1bed03dbaffc
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Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

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