A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol
α-Syn in CSF is a biomarker of neurodegenerative diseases; however, the detection of clinically relevant species is difficult. Here, the authors create a nanobody biosensor that reveals the presence of α-Syn in cells, which allow the detection of transmittable forms of α-Syn present in human CSF.
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Autores principales: | Christoph Gerdes, Natalia Waal, Thomas Offner, Eugenio F. Fornasiero, Nora Wender, Hannes Verbarg, Ivan Manzini, Claudia Trenkwalder, Brit Mollenhauer, Timo Strohäker, Markus Zweckstetter, Stefan Becker, Silvio O. Rizzoli, Fitnat Buket Basmanav, Felipe Opazo |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Materias: | |
Acceso en línea: | https://doaj.org/article/8c988c42912b4775afde11da5ff67e31 |
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