A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol

α-Syn in CSF is a biomarker of neurodegenerative diseases; however, the detection of clinically relevant species is difficult. Here, the authors create a nanobody biosensor that reveals the presence of α-Syn in cells, which allow the detection of transmittable forms of α-Syn present in human CSF.

Guardado en:
Detalles Bibliográficos
Autores principales: Christoph Gerdes, Natalia Waal, Thomas Offner, Eugenio F. Fornasiero, Nora Wender, Hannes Verbarg, Ivan Manzini, Claudia Trenkwalder, Brit Mollenhauer, Timo Strohäker, Markus Zweckstetter, Stefan Becker, Silvio O. Rizzoli, Fitnat Buket Basmanav, Felipe Opazo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Q
Acceso en línea:https://doaj.org/article/8c988c42912b4775afde11da5ff67e31
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!