Ethnicity and cutaneous melanoma in the city of Sao Paulo, Brazil: a case-control study.
<h4>Background</h4>Over the last century the incidence of cutaneous melanoma has increased worldwide, a trend that has also been observed in Brazil. The identified risk factors for melanoma include the pattern of sun exposure, family history, and certain phenotypic features. In addition,...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8c99c8bf2276453d9b0ae5cf085407dd |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8c99c8bf2276453d9b0ae5cf085407dd |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8c99c8bf2276453d9b0ae5cf085407dd2021-11-18T07:20:16ZEthnicity and cutaneous melanoma in the city of Sao Paulo, Brazil: a case-control study.1932-620310.1371/journal.pone.0036348https://doaj.org/article/8c99c8bf2276453d9b0ae5cf085407dd2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22558444/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Over the last century the incidence of cutaneous melanoma has increased worldwide, a trend that has also been observed in Brazil. The identified risk factors for melanoma include the pattern of sun exposure, family history, and certain phenotypic features. In addition, the incidence of melanoma might be influenced by ethnicity. Like many countries, Brazil has high immigration rates and consequently a heterogeneous population. However, Brazil is unique among such countries in that the ethnic heterogeneity of its population is primarily attributable to admixture. This study aimed to evaluate the contribution of European ethnicity to the risk of cutaneous melanoma in Brazil.<h4>Methodology/principal findings</h4>We carried out a hospital-based case-control study in the metropolitan area of Sao Paulo, Brazil. We evaluated 424 hospitalized patients (202 melanoma patients and 222 control patients) regarding phenotypic features, sun exposure, and number of grandparents born in Europe. Through multivariate logistic regression analysis, we found the following variables to be independently associated with melanoma: grandparents born in Europe-Spain (OR = 3.01, 95% CI: 1.03-8.77), Italy (OR = 3.47, 95% CI: 1.41-8.57), a Germanic/Slavic country (OR = 3.06, 95% CI: 1.05-8.93), or ≥ 2 European countries (OR = 2.82, 95% CI: 1.06-7.47); eye color-light brown (OR = 1.99, 95% CI: 1.14-3.84) and green/blue (OR = 4.62; 95% CI 2.22-9.58); pigmented lesion removal (OR = 3.78; 95% CI: 2.21-6.49); no lifetime sunscreen use (OR = 3.08; 95% CI: 1.03-9.22); and lifetime severe sunburn (OR = 1.81; 95% CI: 1.03-3.19).<h4>Conclusions</h4>Our results indicate that European ancestry is a risk factor for cutaneous melanoma. Such risk appears to be related not only to skin type, eye color, and tanning capacity but also to others specific characteristics of European populations introduced in the New World by European immigrants.Olinda C LuizReinaldo José GianiniFernanda T GonçalvesGuilherme FranciscoCyro Festa-NetoJosé Antonio SanchesGilka J F GattasRoger ChammasJosé Eluf-NetoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e36348 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Olinda C Luiz Reinaldo José Gianini Fernanda T Gonçalves Guilherme Francisco Cyro Festa-Neto José Antonio Sanches Gilka J F Gattas Roger Chammas José Eluf-Neto Ethnicity and cutaneous melanoma in the city of Sao Paulo, Brazil: a case-control study. |
| description |
<h4>Background</h4>Over the last century the incidence of cutaneous melanoma has increased worldwide, a trend that has also been observed in Brazil. The identified risk factors for melanoma include the pattern of sun exposure, family history, and certain phenotypic features. In addition, the incidence of melanoma might be influenced by ethnicity. Like many countries, Brazil has high immigration rates and consequently a heterogeneous population. However, Brazil is unique among such countries in that the ethnic heterogeneity of its population is primarily attributable to admixture. This study aimed to evaluate the contribution of European ethnicity to the risk of cutaneous melanoma in Brazil.<h4>Methodology/principal findings</h4>We carried out a hospital-based case-control study in the metropolitan area of Sao Paulo, Brazil. We evaluated 424 hospitalized patients (202 melanoma patients and 222 control patients) regarding phenotypic features, sun exposure, and number of grandparents born in Europe. Through multivariate logistic regression analysis, we found the following variables to be independently associated with melanoma: grandparents born in Europe-Spain (OR = 3.01, 95% CI: 1.03-8.77), Italy (OR = 3.47, 95% CI: 1.41-8.57), a Germanic/Slavic country (OR = 3.06, 95% CI: 1.05-8.93), or ≥ 2 European countries (OR = 2.82, 95% CI: 1.06-7.47); eye color-light brown (OR = 1.99, 95% CI: 1.14-3.84) and green/blue (OR = 4.62; 95% CI 2.22-9.58); pigmented lesion removal (OR = 3.78; 95% CI: 2.21-6.49); no lifetime sunscreen use (OR = 3.08; 95% CI: 1.03-9.22); and lifetime severe sunburn (OR = 1.81; 95% CI: 1.03-3.19).<h4>Conclusions</h4>Our results indicate that European ancestry is a risk factor for cutaneous melanoma. Such risk appears to be related not only to skin type, eye color, and tanning capacity but also to others specific characteristics of European populations introduced in the New World by European immigrants. |
| format |
article |
| author |
Olinda C Luiz Reinaldo José Gianini Fernanda T Gonçalves Guilherme Francisco Cyro Festa-Neto José Antonio Sanches Gilka J F Gattas Roger Chammas José Eluf-Neto |
| author_facet |
Olinda C Luiz Reinaldo José Gianini Fernanda T Gonçalves Guilherme Francisco Cyro Festa-Neto José Antonio Sanches Gilka J F Gattas Roger Chammas José Eluf-Neto |
| author_sort |
Olinda C Luiz |
| title |
Ethnicity and cutaneous melanoma in the city of Sao Paulo, Brazil: a case-control study. |
| title_short |
Ethnicity and cutaneous melanoma in the city of Sao Paulo, Brazil: a case-control study. |
| title_full |
Ethnicity and cutaneous melanoma in the city of Sao Paulo, Brazil: a case-control study. |
| title_fullStr |
Ethnicity and cutaneous melanoma in the city of Sao Paulo, Brazil: a case-control study. |
| title_full_unstemmed |
Ethnicity and cutaneous melanoma in the city of Sao Paulo, Brazil: a case-control study. |
| title_sort |
ethnicity and cutaneous melanoma in the city of sao paulo, brazil: a case-control study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/8c99c8bf2276453d9b0ae5cf085407dd |
| work_keys_str_mv |
AT olindacluiz ethnicityandcutaneousmelanomainthecityofsaopaulobrazilacasecontrolstudy AT reinaldojosegianini ethnicityandcutaneousmelanomainthecityofsaopaulobrazilacasecontrolstudy AT fernandatgoncalves ethnicityandcutaneousmelanomainthecityofsaopaulobrazilacasecontrolstudy AT guilhermefrancisco ethnicityandcutaneousmelanomainthecityofsaopaulobrazilacasecontrolstudy AT cyrofestaneto ethnicityandcutaneousmelanomainthecityofsaopaulobrazilacasecontrolstudy AT joseantoniosanches ethnicityandcutaneousmelanomainthecityofsaopaulobrazilacasecontrolstudy AT gilkajfgattas ethnicityandcutaneousmelanomainthecityofsaopaulobrazilacasecontrolstudy AT rogerchammas ethnicityandcutaneousmelanomainthecityofsaopaulobrazilacasecontrolstudy AT joseelufneto ethnicityandcutaneousmelanomainthecityofsaopaulobrazilacasecontrolstudy |
| _version_ |
1718423610577649664 |