An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.

<h4>Background</h4>Numerous individually underpowered association studies have been conducted on endothelial nitric oxide synthase (eNOS) genetic variants across different ethnic populations, however, the results are often irreproducible. We therefore aimed to meta-analyze three eNOS wid...

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Autores principales:	Wenquan Niu, Yue Qi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8c9a33cb08614a8bb7cd1a28affd5bee
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spelling	oai:doaj.org-article:8c9a33cb08614a8bb7cd1a28affd5bee2021-11-18T06:46:43ZAn updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.1932-620310.1371/journal.pone.0024266https://doaj.org/article/8c9a33cb08614a8bb7cd1a28affd5bee2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21912683/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Numerous individually underpowered association studies have been conducted on endothelial nitric oxide synthase (eNOS) genetic variants across different ethnic populations, however, the results are often irreproducible. We therefore aimed to meta-analyze three eNOS widely-evaluated polymorphisms, G894T (rs1799983) in exon 7, 4b/a in intron 4, and T-786C (rs2070744) in promoter region, in association with hypertension from both English and Chinese publications, while addressing between-study heterogeneity and publication bias.<h4>Methods</h4>Data were analyzed using Stata software (version 11.0), and random-effects model was applied irrespective of between-study heterogeneity, which was evaluated by subgroup and meta-regression analyses. Publication bias was weighed using the Egger's test and funnel plot.<h4>Results</h4>There were total 19284/26003 cases/controls for G894T, and 6890/6858 for 4b/a, and 5346/6392 for T-786C polymorphism. Overall comparison of allele 894T with 894G in all study populations yielded a 16% increased risk for hypertension (odds ratio [OR] = 1.16; 95% confidence interval [95% CI]: 1.07-1.27; P = 0.001), and particularly a 32% increased risk (95% CI: 1.16-1.52; P<0.0005) in Asians and a 40% increased risk (95% CI: 1.19-1.65; P<0.0005) in Chinese. Further subgroup analyses suggested that published languages accounted for the heterogeneity for G894T polymorphism. The overall OR of allele 4a versus 4b was 1.29 (95% CI: 1.13-1.46; P<0.0005) in all study populations, and this estimate was potentiated in Asians (OR = 1.42; 95% CI: 1.16-1.72; P<0.0005). For T-786C, ethnicity-stratified analyses suggested a significantly increased risk for -786C allele (OR = 1.25; 95% CI: 1.06-1.47; P = 0.007) and -786CC genotype (OR = 1.69; 95% CI: 1.20-2.38; P = 0.003) in Whites. As an aside, the aforementioned risk estimates reached significance after Bonferroni correction. Finally, meta-regression analysis on other study-level covariates failed to provide any significance for all polymorphisms.<h4>Conclusion</h4>We, via a comprehensive meta-analysis, ascertained the role of eNOS G894T and 4b/a polymorphisms on hypertension in Asians, and T-786C polymorphism in Whites.Wenquan NiuYue QiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24266 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wenquan Niu Yue Qi An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.
description	<h4>Background</h4>Numerous individually underpowered association studies have been conducted on endothelial nitric oxide synthase (eNOS) genetic variants across different ethnic populations, however, the results are often irreproducible. We therefore aimed to meta-analyze three eNOS widely-evaluated polymorphisms, G894T (rs1799983) in exon 7, 4b/a in intron 4, and T-786C (rs2070744) in promoter region, in association with hypertension from both English and Chinese publications, while addressing between-study heterogeneity and publication bias.<h4>Methods</h4>Data were analyzed using Stata software (version 11.0), and random-effects model was applied irrespective of between-study heterogeneity, which was evaluated by subgroup and meta-regression analyses. Publication bias was weighed using the Egger's test and funnel plot.<h4>Results</h4>There were total 19284/26003 cases/controls for G894T, and 6890/6858 for 4b/a, and 5346/6392 for T-786C polymorphism. Overall comparison of allele 894T with 894G in all study populations yielded a 16% increased risk for hypertension (odds ratio [OR] = 1.16; 95% confidence interval [95% CI]: 1.07-1.27; P = 0.001), and particularly a 32% increased risk (95% CI: 1.16-1.52; P<0.0005) in Asians and a 40% increased risk (95% CI: 1.19-1.65; P<0.0005) in Chinese. Further subgroup analyses suggested that published languages accounted for the heterogeneity for G894T polymorphism. The overall OR of allele 4a versus 4b was 1.29 (95% CI: 1.13-1.46; P<0.0005) in all study populations, and this estimate was potentiated in Asians (OR = 1.42; 95% CI: 1.16-1.72; P<0.0005). For T-786C, ethnicity-stratified analyses suggested a significantly increased risk for -786C allele (OR = 1.25; 95% CI: 1.06-1.47; P = 0.007) and -786CC genotype (OR = 1.69; 95% CI: 1.20-2.38; P = 0.003) in Whites. As an aside, the aforementioned risk estimates reached significance after Bonferroni correction. Finally, meta-regression analysis on other study-level covariates failed to provide any significance for all polymorphisms.<h4>Conclusion</h4>We, via a comprehensive meta-analysis, ascertained the role of eNOS G894T and 4b/a polymorphisms on hypertension in Asians, and T-786C polymorphism in Whites.
format	article
author	Wenquan Niu Yue Qi
author_facet	Wenquan Niu Yue Qi
author_sort	Wenquan Niu
title	An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.
title_short	An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.
title_full	An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.
title_fullStr	An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.
title_full_unstemmed	An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.
title_sort	updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/8c9a33cb08614a8bb7cd1a28affd5bee
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An updated meta-analysis of endothelial nitric oxide synthase gene: three well-characterized polymorphisms with hypertension.

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