Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators

Both the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury. Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner. During inflammation...

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Autores principales:	Javier Perez-Hernandez, Valerio Chiurchiù, Sylvain Perruche, Sylvaine You
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	resolution adaptive immunity autoimmunity T cell therapy specialized pro-resolving lipid mediators (SPMs) Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8c9b52be948d4ead82a8151922b16622
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spelling	oai:doaj.org-article:8c9b52be948d4ead82a8151922b166222021-11-16T07:32:02ZRegulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators1664-322410.3389/fimmu.2021.768133https://doaj.org/article/8c9b52be948d4ead82a8151922b166222021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.768133/fullhttps://doaj.org/toc/1664-3224Both the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury. Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner. During inflammation and its resolution, polymorphonuclear cells (PMNs) and macrophages switch from producing pro-inflammatory prostaglandins and leukotrienes to specialized pro-resolving lipid mediators (SPMs), namely, lipoxins, resolvins, protectins, and maresins, which are operative at the local level to limit further inflammation and tissue injury and restore homeostasis. Accumulating evidences expand now the role and actions of these lipid mediators from innate to adaptive immunity. In particular, SPMs have been shown to contribute to the control of chronic inflammation, and alterations in their production and/or function have been associated with the persistence of several pathological conditions, including autoimmunity, in human and experimental models. In this review, we focus on the impact of pro-resolving lipids on T cells through their ability to modulate T-cell responses. In particular, the effects of the different families of SPMs to restrain effector T-cell functions while promoting regulatory T cells will be reviewed, along with the underlying mechanisms. Furthermore, the emerging concept of SPMs as new biological markers for disease diagnostic and progression and as putative therapeutic tools to regulate the development and magnitude of inflammatory and autoimmune diseases is discussed.Javier Perez-HernandezJavier Perez-HernandezValerio ChiurchiùValerio ChiurchiùSylvain PerrucheSylvain PerrucheSylvaine YouFrontiers Media S.A.articleresolutionadaptive immunityautoimmunityT celltherapyspecialized pro-resolving lipid mediators (SPMs)Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	resolution adaptive immunity autoimmunity T cell therapy specialized pro-resolving lipid mediators (SPMs) Immunologic diseases. Allergy RC581-607
spellingShingle	resolution adaptive immunity autoimmunity T cell therapy specialized pro-resolving lipid mediators (SPMs) Immunologic diseases. Allergy RC581-607 Javier Perez-Hernandez Javier Perez-Hernandez Valerio Chiurchiù Valerio Chiurchiù Sylvain Perruche Sylvain Perruche Sylvaine You Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
description	Both the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury. Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner. During inflammation and its resolution, polymorphonuclear cells (PMNs) and macrophages switch from producing pro-inflammatory prostaglandins and leukotrienes to specialized pro-resolving lipid mediators (SPMs), namely, lipoxins, resolvins, protectins, and maresins, which are operative at the local level to limit further inflammation and tissue injury and restore homeostasis. Accumulating evidences expand now the role and actions of these lipid mediators from innate to adaptive immunity. In particular, SPMs have been shown to contribute to the control of chronic inflammation, and alterations in their production and/or function have been associated with the persistence of several pathological conditions, including autoimmunity, in human and experimental models. In this review, we focus on the impact of pro-resolving lipids on T cells through their ability to modulate T-cell responses. In particular, the effects of the different families of SPMs to restrain effector T-cell functions while promoting regulatory T cells will be reviewed, along with the underlying mechanisms. Furthermore, the emerging concept of SPMs as new biological markers for disease diagnostic and progression and as putative therapeutic tools to regulate the development and magnitude of inflammatory and autoimmune diseases is discussed.
format	article
author	Javier Perez-Hernandez Javier Perez-Hernandez Valerio Chiurchiù Valerio Chiurchiù Sylvain Perruche Sylvain Perruche Sylvaine You
author_facet	Javier Perez-Hernandez Javier Perez-Hernandez Valerio Chiurchiù Valerio Chiurchiù Sylvain Perruche Sylvain Perruche Sylvaine You
author_sort	Javier Perez-Hernandez
title	Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
title_short	Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
title_full	Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
title_fullStr	Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
title_full_unstemmed	Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
title_sort	regulation of t-cell immune responses by pro-resolving lipid mediators
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8c9b52be948d4ead82a8151922b16622
work_keys_str_mv	AT javierperezhernandez regulationoftcellimmuneresponsesbyproresolvinglipidmediators AT javierperezhernandez regulationoftcellimmuneresponsesbyproresolvinglipidmediators AT valeriochiurchiu regulationoftcellimmuneresponsesbyproresolvinglipidmediators AT valeriochiurchiu regulationoftcellimmuneresponsesbyproresolvinglipidmediators AT sylvainperruche regulationoftcellimmuneresponsesbyproresolvinglipidmediators AT sylvainperruche regulationoftcellimmuneresponsesbyproresolvinglipidmediators AT sylvaineyou regulationoftcellimmuneresponsesbyproresolvinglipidmediators
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Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators

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