The role of CD40 receptor-ligand system in the development of diabetes mellitus and its complications

The CD40 receptor-CD40 ligand system, along with other signal molecules, plays an important role in the development of immune and inflammatoryreactions. CD40R and CD40L are expressed in lymphocytes, monocytes, platelets, endothelial and smooth muscle cells, pancreatic beta-cells, adipocytes,and othe...

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Autores principales:	Irina Arkad'evna Bondar', Vadim Valer'evich Klimontov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2011
Materias:	diabetes mellitus atherosclerosis diabetic nephropathy cd40-cd40l system inflammation Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/8c9d71d861564059b45b25db51d626d1
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id	oai:doaj.org-article:8c9d71d861564059b45b25db51d626d1
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spelling	oai:doaj.org-article:8c9d71d861564059b45b25db51d626d12021-11-14T09:00:16ZThe role of CD40 receptor-ligand system in the development of diabetes mellitus and its complications2072-03512072-037810.14341/2072-0351-6219https://doaj.org/article/8c9d71d861564059b45b25db51d626d12011-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6219https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The CD40 receptor-CD40 ligand system, along with other signal molecules, plays an important role in the development of immune and inflammatoryreactions. CD40R and CD40L are expressed in lymphocytes, monocytes, platelets, endothelial and smooth muscle cells, pancreatic beta-cells, adipocytes,and other cells. The CD40-CD40L system participates in the formation of immune and inflammatory reactions in the cardiovascular system,platelet production and development of autoimmune diseases. Signals mediated through CD40 receptors are involved in the autoimmune process intype 1 diabetes, inflammation of adipose tissue in DM2, development of atherosclerosis and diabetic nephropathy. Therefore, the CD40-CD40Lsystem can be regarded as a universal pathogenetic factor responsible for immune and inflammatory processes, hyperglycemia, and vascular complications.Measurement of CD40 expression in lymphocytes, monocytes, and adipocytes and sCD40L in blood and urine can be used to diagnose andforetell immune and inflammatory processes associated with diabetes mellitus. HMG-CoA reductase inhibitors (statins) and disaggregants (aspirin,clopidogrel) inhibit activity of the CD40-CD40L system. Further studies of possibilities of pharmacological correction of this system may provide abasis for the development of new therapeutic modalities for the management of diabetes and its complications.Irina Arkad'evna Bondar'Vadim Valer'evich KlimontovEndocrinology Research Centrearticlediabetes mellitusatherosclerosisdiabetic nephropathycd40-cd40l systeminflammationNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 3, Pp 21-25 (2011)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus atherosclerosis diabetic nephropathy cd40-cd40l system inflammation Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus atherosclerosis diabetic nephropathy cd40-cd40l system inflammation Nutritional diseases. Deficiency diseases RC620-627 Irina Arkad'evna Bondar' Vadim Valer'evich Klimontov The role of CD40 receptor-ligand system in the development of diabetes mellitus and its complications
description	The CD40 receptor-CD40 ligand system, along with other signal molecules, plays an important role in the development of immune and inflammatoryreactions. CD40R and CD40L are expressed in lymphocytes, monocytes, platelets, endothelial and smooth muscle cells, pancreatic beta-cells, adipocytes,and other cells. The CD40-CD40L system participates in the formation of immune and inflammatory reactions in the cardiovascular system,platelet production and development of autoimmune diseases. Signals mediated through CD40 receptors are involved in the autoimmune process intype 1 diabetes, inflammation of adipose tissue in DM2, development of atherosclerosis and diabetic nephropathy. Therefore, the CD40-CD40Lsystem can be regarded as a universal pathogenetic factor responsible for immune and inflammatory processes, hyperglycemia, and vascular complications.Measurement of CD40 expression in lymphocytes, monocytes, and adipocytes and sCD40L in blood and urine can be used to diagnose andforetell immune and inflammatory processes associated with diabetes mellitus. HMG-CoA reductase inhibitors (statins) and disaggregants (aspirin,clopidogrel) inhibit activity of the CD40-CD40L system. Further studies of possibilities of pharmacological correction of this system may provide abasis for the development of new therapeutic modalities for the management of diabetes and its complications.
format	article
author	Irina Arkad'evna Bondar' Vadim Valer'evich Klimontov
author_facet	Irina Arkad'evna Bondar' Vadim Valer'evich Klimontov
author_sort	Irina Arkad'evna Bondar'
title	The role of CD40 receptor-ligand system in the development of diabetes mellitus and its complications
title_short	The role of CD40 receptor-ligand system in the development of diabetes mellitus and its complications
title_full	The role of CD40 receptor-ligand system in the development of diabetes mellitus and its complications
title_fullStr	The role of CD40 receptor-ligand system in the development of diabetes mellitus and its complications
title_full_unstemmed	The role of CD40 receptor-ligand system in the development of diabetes mellitus and its complications
title_sort	role of cd40 receptor-ligand system in the development of diabetes mellitus and its complications
publisher	Endocrinology Research Centre
publishDate	2011
url	https://doaj.org/article/8c9d71d861564059b45b25db51d626d1
work_keys_str_mv	AT irinaarkadevnabondar theroleofcd40receptorligandsysteminthedevelopmentofdiabetesmellitusanditscomplications AT vadimvalerevichklimontov theroleofcd40receptorligandsysteminthedevelopmentofdiabetesmellitusanditscomplications AT irinaarkadevnabondar roleofcd40receptorligandsysteminthedevelopmentofdiabetesmellitusanditscomplications AT vadimvalerevichklimontov roleofcd40receptorligandsysteminthedevelopmentofdiabetesmellitusanditscomplications
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The role of CD40 receptor-ligand system in the development of diabetes mellitus and its complications

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