Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

Plexins are the receptors for the guidance molecules semaphorins and regulate immunity and the development of the nervous and cardiovascular systems. Here authors present a structure of full-length human PlexinC1 in complex with its ligand A39R, which reveals how inter-domain interactions couple ext...

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Autores principales:	Yi-Chun Kuo, Hua Chen, Guijun Shang, Emiko Uchikawa, Hui Tian, Xiao-Chen Bai, Xuewu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ca1c43a536c46318a1ddd5ba7d60d01
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spelling	oai:doaj.org-article:8ca1c43a536c46318a1ddd5ba7d60d012021-12-02T16:49:47ZCryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation10.1038/s41467-020-15862-02041-1723https://doaj.org/article/8ca1c43a536c46318a1ddd5ba7d60d012020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15862-0https://doaj.org/toc/2041-1723Plexins are the receptors for the guidance molecules semaphorins and regulate immunity and the development of the nervous and cardiovascular systems. Here authors present a structure of full-length human PlexinC1 in complex with its ligand A39R, which reveals how inter-domain interactions couple extracellular ligand binding to receptor activation and signaling.Yi-Chun KuoHua ChenGuijun ShangEmiko UchikawaHui TianXiao-Chen BaiXuewu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi-Chun Kuo Hua Chen Guijun Shang Emiko Uchikawa Hui Tian Xiao-Chen Bai Xuewu Zhang Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
description	Plexins are the receptors for the guidance molecules semaphorins and regulate immunity and the development of the nervous and cardiovascular systems. Here authors present a structure of full-length human PlexinC1 in complex with its ligand A39R, which reveals how inter-domain interactions couple extracellular ligand binding to receptor activation and signaling.
format	article
author	Yi-Chun Kuo Hua Chen Guijun Shang Emiko Uchikawa Hui Tian Xiao-Chen Bai Xuewu Zhang
author_facet	Yi-Chun Kuo Hua Chen Guijun Shang Emiko Uchikawa Hui Tian Xiao-Chen Bai Xuewu Zhang
author_sort	Yi-Chun Kuo
title	Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
title_short	Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
title_full	Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
title_fullStr	Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
title_full_unstemmed	Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation
title_sort	cryo-em structure of the plexinc1/a39r complex reveals inter-domain interactions critical for ligand-induced activation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8ca1c43a536c46318a1ddd5ba7d60d01
work_keys_str_mv	AT yichunkuo cryoemstructureoftheplexinc1a39rcomplexrevealsinterdomaininteractionscriticalforligandinducedactivation AT huachen cryoemstructureoftheplexinc1a39rcomplexrevealsinterdomaininteractionscriticalforligandinducedactivation AT guijunshang cryoemstructureoftheplexinc1a39rcomplexrevealsinterdomaininteractionscriticalforligandinducedactivation AT emikouchikawa cryoemstructureoftheplexinc1a39rcomplexrevealsinterdomaininteractionscriticalforligandinducedactivation AT huitian cryoemstructureoftheplexinc1a39rcomplexrevealsinterdomaininteractionscriticalforligandinducedactivation AT xiaochenbai cryoemstructureoftheplexinc1a39rcomplexrevealsinterdomaininteractionscriticalforligandinducedactivation AT xuewuzhang cryoemstructureoftheplexinc1a39rcomplexrevealsinterdomaininteractionscriticalforligandinducedactivation
_version_	1718383228161622016

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

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