EFFECT OF SOME ORGANIC SOLVENTS IN SATURATION ON THE THERMODYNAMIC FUNCTIONS OF DISSOLUTION FOR NAPROXEN IN AQUEOUS MEDIA AT PHYSIOLOGICAL pH

Naproxen (NAP) is a widely used non-steroidal anti-inflammatory drug, whose physicochemical properties have not been thoroughly studied. As a contribution to the physicochemical characterization of NAP in aqueous solution, we evaluated the effect of some organic solvents in aqueous saturation on the...

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Autores principales:	Carolina P. MORA G., Helber J. BARBOSA B., Fleming MARTÍNEZ R.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Naproxen solubility solvation thermodynamics. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/8ca7f78b196b485f9031b1c9858f9c66
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spelling	oai:doaj.org-article:8ca7f78b196b485f9031b1c9858f9c662021-11-19T04:21:42ZEFFECT OF SOME ORGANIC SOLVENTS IN SATURATION ON THE THERMODYNAMIC FUNCTIONS OF DISSOLUTION FOR NAPROXEN IN AQUEOUS MEDIA AT PHYSIOLOGICAL pH0121-40042145-2660https://doaj.org/article/8ca7f78b196b485f9031b1c9858f9c662009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/567https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Naproxen (NAP) is a widely used non-steroidal anti-inflammatory drug, whose physicochemical properties have not been thoroughly studied. As a contribution to the physicochemical characterization of NAP in aqueous solution, we evaluated the effect of some organic solvents in aqueous saturation on the thermodynamic functions of a NAP solution at physiological pH. Based on solubility values at different temperatures, using the equations of Gibbs and Van´t Hoff, the thermodynamic functions Gibb´s free energy, enthalpy and enthropy were determined for the solution and salvation processes of NAP in three aqueous saturated media at pH 7,4, each one of them with octanol W(ROH), isopropyl myristate W(IPM), or chloroform W(CLF). Results were compared with those obtained for NAP in pure buffer, W, previously reported. Solubility of NAP at 25º C increased in the following order: W(ROH) < W < W(IPM) ≤ W(CLF). In every system, enthalpies and enthropies of the solution of this drug were, respectively, positive and negative; on the other hand, solvation thermodynamic functions were negative in all cases. Results are discussed in terms of solute-solvent interactions. Carolina P. MORA G.Helber J. BARBOSA B.Fleming MARTÍNEZ R.Universidad de AntioquiaarticleNaproxensolubilitysolvationthermodynamics.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 14, Iss 1 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Naproxen solubility solvation thermodynamics. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Naproxen solubility solvation thermodynamics. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Carolina P. MORA G. Helber J. BARBOSA B. Fleming MARTÍNEZ R. EFFECT OF SOME ORGANIC SOLVENTS IN SATURATION ON THE THERMODYNAMIC FUNCTIONS OF DISSOLUTION FOR NAPROXEN IN AQUEOUS MEDIA AT PHYSIOLOGICAL pH
description	Naproxen (NAP) is a widely used non-steroidal anti-inflammatory drug, whose physicochemical properties have not been thoroughly studied. As a contribution to the physicochemical characterization of NAP in aqueous solution, we evaluated the effect of some organic solvents in aqueous saturation on the thermodynamic functions of a NAP solution at physiological pH. Based on solubility values at different temperatures, using the equations of Gibbs and Van´t Hoff, the thermodynamic functions Gibb´s free energy, enthalpy and enthropy were determined for the solution and salvation processes of NAP in three aqueous saturated media at pH 7,4, each one of them with octanol W(ROH), isopropyl myristate W(IPM), or chloroform W(CLF). Results were compared with those obtained for NAP in pure buffer, W, previously reported. Solubility of NAP at 25º C increased in the following order: W(ROH) < W < W(IPM) ≤ W(CLF). In every system, enthalpies and enthropies of the solution of this drug were, respectively, positive and negative; on the other hand, solvation thermodynamic functions were negative in all cases. Results are discussed in terms of solute-solvent interactions.
format	article
author	Carolina P. MORA G. Helber J. BARBOSA B. Fleming MARTÍNEZ R.
author_facet	Carolina P. MORA G. Helber J. BARBOSA B. Fleming MARTÍNEZ R.
author_sort	Carolina P. MORA G.
title	EFFECT OF SOME ORGANIC SOLVENTS IN SATURATION ON THE THERMODYNAMIC FUNCTIONS OF DISSOLUTION FOR NAPROXEN IN AQUEOUS MEDIA AT PHYSIOLOGICAL pH
title_short	EFFECT OF SOME ORGANIC SOLVENTS IN SATURATION ON THE THERMODYNAMIC FUNCTIONS OF DISSOLUTION FOR NAPROXEN IN AQUEOUS MEDIA AT PHYSIOLOGICAL pH
title_full	EFFECT OF SOME ORGANIC SOLVENTS IN SATURATION ON THE THERMODYNAMIC FUNCTIONS OF DISSOLUTION FOR NAPROXEN IN AQUEOUS MEDIA AT PHYSIOLOGICAL pH
title_fullStr	EFFECT OF SOME ORGANIC SOLVENTS IN SATURATION ON THE THERMODYNAMIC FUNCTIONS OF DISSOLUTION FOR NAPROXEN IN AQUEOUS MEDIA AT PHYSIOLOGICAL pH
title_full_unstemmed	EFFECT OF SOME ORGANIC SOLVENTS IN SATURATION ON THE THERMODYNAMIC FUNCTIONS OF DISSOLUTION FOR NAPROXEN IN AQUEOUS MEDIA AT PHYSIOLOGICAL pH
title_sort	effect of some organic solvents in saturation on the thermodynamic functions of dissolution for naproxen in aqueous media at physiological ph
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/8ca7f78b196b485f9031b1c9858f9c66
work_keys_str_mv	AT carolinapmorag effectofsomeorganicsolventsinsaturationonthethermodynamicfunctionsofdissolutionfornaproxeninaqueousmediaatphysiologicalph AT helberjbarbosab effectofsomeorganicsolventsinsaturationonthethermodynamicfunctionsofdissolutionfornaproxeninaqueousmediaatphysiologicalph AT flemingmartinezr effectofsomeorganicsolventsinsaturationonthethermodynamicfunctionsofdissolutionfornaproxeninaqueousmediaatphysiologicalph
_version_	1718420431641247744

EFFECT OF SOME ORGANIC SOLVENTS IN SATURATION ON THE THERMODYNAMIC FUNCTIONS OF DISSOLUTION FOR NAPROXEN IN AQUEOUS MEDIA AT PHYSIOLOGICAL pH

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