Risk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma

Abstract Background One of the major concerns of patients with upper tract urothelial carcinoma (UTUC) treated with nephroureterectomy is intravesical recurrence (IVR). The purpose of the present study was to investigate the predictive risk factors for IVR after retroperitoneoscopic nephroureterecto...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Masato Yanagi, Tsutomu Hamasaki, Jun Akatsuka, Yuki Endo, Hayato Takeda, Yukihiro Kondo
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Upper urinary tract Urothelial carcinoma Retroperitoneoscopic nephroureterectomy Pneumoretroperitoneum time Intravesical recurrence Urine cytology Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/8ca86caa62384464a470671033aedc8b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8ca86caa62384464a470671033aedc8b
record_format	dspace
spelling	oai:doaj.org-article:8ca86caa62384464a470671033aedc8b2021-12-05T12:19:54ZRisk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma10.1186/s12894-021-00932-21471-2490https://doaj.org/article/8ca86caa62384464a470671033aedc8b2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12894-021-00932-2https://doaj.org/toc/1471-2490Abstract Background One of the major concerns of patients with upper tract urothelial carcinoma (UTUC) treated with nephroureterectomy is intravesical recurrence (IVR). The purpose of the present study was to investigate the predictive risk factors for IVR after retroperitoneoscopic nephroureterectomy (RNU) for UTUC. Methods Clinicopathological and surgical information were collected from the medical records of 73 patients treated with RNU for non-metastatic UTUC, without a history of or concomitant bladder cancer. The association between IVR after RNU and clinicopathological and surgery-related factors, including preoperative urine cytology and pneumoretroperitoneum time, was analyzed using the Fisher exact test. Results During the median follow-up time of 39.1 months, 18 (24.7%) patients had subsequent IVR after RNU. The 1- and 3-year IVR-free survival rates were 85.9% and 76.5%, respectively. The Fisher exact test revealed that prolonged pneumoretroperitoneum time of ≥ 210 min was a risk factor for IVR in 1 year after RNU (p = 0.0358) and positive urine cytology was a risk factor for IVR in 3 years after RNU (p = 0.0352). Conclusions In UTUC, the occurrences of IVR in 1 and 3 years after RNU are highly probable when the pneumoretroperitoneum time is prolonged (≥ 210 min) and in patients with positive urine cytology, respectively. Strict follow-up after RNU is more probable recommended for these patients.Masato YanagiTsutomu HamasakiJun AkatsukaYuki EndoHayato TakedaYukihiro KondoBMCarticleUpper urinary tractUrothelial carcinomaRetroperitoneoscopic nephroureterectomyPneumoretroperitoneum timeIntravesical recurrenceUrine cytologyDiseases of the genitourinary system. UrologyRC870-923ENBMC Urology, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Upper urinary tract Urothelial carcinoma Retroperitoneoscopic nephroureterectomy Pneumoretroperitoneum time Intravesical recurrence Urine cytology Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Upper urinary tract Urothelial carcinoma Retroperitoneoscopic nephroureterectomy Pneumoretroperitoneum time Intravesical recurrence Urine cytology Diseases of the genitourinary system. Urology RC870-923 Masato Yanagi Tsutomu Hamasaki Jun Akatsuka Yuki Endo Hayato Takeda Yukihiro Kondo Risk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma
description	Abstract Background One of the major concerns of patients with upper tract urothelial carcinoma (UTUC) treated with nephroureterectomy is intravesical recurrence (IVR). The purpose of the present study was to investigate the predictive risk factors for IVR after retroperitoneoscopic nephroureterectomy (RNU) for UTUC. Methods Clinicopathological and surgical information were collected from the medical records of 73 patients treated with RNU for non-metastatic UTUC, without a history of or concomitant bladder cancer. The association between IVR after RNU and clinicopathological and surgery-related factors, including preoperative urine cytology and pneumoretroperitoneum time, was analyzed using the Fisher exact test. Results During the median follow-up time of 39.1 months, 18 (24.7%) patients had subsequent IVR after RNU. The 1- and 3-year IVR-free survival rates were 85.9% and 76.5%, respectively. The Fisher exact test revealed that prolonged pneumoretroperitoneum time of ≥ 210 min was a risk factor for IVR in 1 year after RNU (p = 0.0358) and positive urine cytology was a risk factor for IVR in 3 years after RNU (p = 0.0352). Conclusions In UTUC, the occurrences of IVR in 1 and 3 years after RNU are highly probable when the pneumoretroperitoneum time is prolonged (≥ 210 min) and in patients with positive urine cytology, respectively. Strict follow-up after RNU is more probable recommended for these patients.
format	article
author	Masato Yanagi Tsutomu Hamasaki Jun Akatsuka Yuki Endo Hayato Takeda Yukihiro Kondo
author_facet	Masato Yanagi Tsutomu Hamasaki Jun Akatsuka Yuki Endo Hayato Takeda Yukihiro Kondo
author_sort	Masato Yanagi
title	Risk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma
title_short	Risk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma
title_full	Risk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma
title_fullStr	Risk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma
title_full_unstemmed	Risk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma
title_sort	risk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8ca86caa62384464a470671033aedc8b
work_keys_str_mv	AT masatoyanagi riskfactoranalysisofintravesicalrecurrenceafterretroperitoneoscopicnephroureterectomyforuppertracturothelialcarcinoma AT tsutomuhamasaki riskfactoranalysisofintravesicalrecurrenceafterretroperitoneoscopicnephroureterectomyforuppertracturothelialcarcinoma AT junakatsuka riskfactoranalysisofintravesicalrecurrenceafterretroperitoneoscopicnephroureterectomyforuppertracturothelialcarcinoma AT yukiendo riskfactoranalysisofintravesicalrecurrenceafterretroperitoneoscopicnephroureterectomyforuppertracturothelialcarcinoma AT hayatotakeda riskfactoranalysisofintravesicalrecurrenceafterretroperitoneoscopicnephroureterectomyforuppertracturothelialcarcinoma AT yukihirokondo riskfactoranalysisofintravesicalrecurrenceafterretroperitoneoscopicnephroureterectomyforuppertracturothelialcarcinoma
_version_	1718372028543664128

Risk factor analysis of intravesical recurrence after retroperitoneoscopic nephroureterectomy for upper tract urothelial carcinoma

Ejemplares similares