A study of Spirometric parameters in non asthmatic allergic rhinitis

Introduction: Allergic rhinitis (AR) is a common IgE -mediated inflammatory condition characterised by sneezing, nasal congestion, itching and rhinorrhoea. Nasal allergy is a strong risk factor for the onset of asthma in adults. Bronchial hyper-responsiveness (BHR) is a distinct feature of pathophys...

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Autores principales:	Devika Thayyezhuth, Rajesh Venkataram, Vadisha Srinivas Bhat, Rajeshwary Aroor
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Absolute eosinophil count Bronchial hyperresponsiveness Forced vital capacity Serum total immunoglobulin E Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/8ca98607975145cf8080aa1eb59850be
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spelling	oai:doaj.org-article:8ca98607975145cf8080aa1eb59850be2021-12-02T05:02:21ZA study of Spirometric parameters in non asthmatic allergic rhinitis2405-844010.1016/j.heliyon.2021.e08270https://doaj.org/article/8ca98607975145cf8080aa1eb59850be2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021023732https://doaj.org/toc/2405-8440Introduction: Allergic rhinitis (AR) is a common IgE -mediated inflammatory condition characterised by sneezing, nasal congestion, itching and rhinorrhoea. Nasal allergy is a strong risk factor for the onset of asthma in adults. Bronchial hyper-responsiveness (BHR) is a distinct feature of pathophysiology in asthma. Spirometric parameters like Forced Expiratory Volume in first second [FEV1] and Forced Expiratory Flow [FEF 25–75%] are known to be impaired in patients with allergic rhinitis. We studied these parameters in subjects of AR who have never experienced any chest symptoms. It is well known that, subjects with allergic rhinitis are at greater risk of developing overt bronchial asthma in future. Methods: All patients presented with symptoms of allergic rhinitis without history of bronchial asthma were included. Patients those who were clinically diagnosed with allergic rhinitis were evaluated with absolute eosinophilic count, serum IgE and Spirometric assessment. In spirometry, post bronchodilator FEV1 reversibility and post bronchodilator FEF 25–75% values were used to assess lower airway abnormalities. Results: Among 61 subjects, 32 were males and 29 were females. The maximum numbers [28] of patients were in 21–35 age group. Absolute eosinophil count was elevated in 38% of patients. 33% of patients showed elevated IgE values above 1000. 43% of patients showed FEV1 reversibility which is a sign of Bronchial hyperreactivity. 5% of patients showed impaired post bronchodilator FEF 25–75% which indicates presence of small airway disease. There was significant correlation between FEV1 reversibility and elevated IgE. Conclusion: Impaired spirometric parameters indicate coexistence of bronchial impairment and hence predisposition to progression from allergic rhinitis alone to overt asthma in future. Thus careful evaluation of lower airway has to be done to rule out coexisting subclinical asthma.Devika ThayyezhuthRajesh VenkataramVadisha Srinivas BhatRajeshwary AroorElsevierarticleAbsolute eosinophil countBronchial hyperresponsivenessForced vital capacitySerum total immunoglobulin EScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08270- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Absolute eosinophil count Bronchial hyperresponsiveness Forced vital capacity Serum total immunoglobulin E Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Absolute eosinophil count Bronchial hyperresponsiveness Forced vital capacity Serum total immunoglobulin E Science (General) Q1-390 Social sciences (General) H1-99 Devika Thayyezhuth Rajesh Venkataram Vadisha Srinivas Bhat Rajeshwary Aroor A study of Spirometric parameters in non asthmatic allergic rhinitis
description	Introduction: Allergic rhinitis (AR) is a common IgE -mediated inflammatory condition characterised by sneezing, nasal congestion, itching and rhinorrhoea. Nasal allergy is a strong risk factor for the onset of asthma in adults. Bronchial hyper-responsiveness (BHR) is a distinct feature of pathophysiology in asthma. Spirometric parameters like Forced Expiratory Volume in first second [FEV1] and Forced Expiratory Flow [FEF 25–75%] are known to be impaired in patients with allergic rhinitis. We studied these parameters in subjects of AR who have never experienced any chest symptoms. It is well known that, subjects with allergic rhinitis are at greater risk of developing overt bronchial asthma in future. Methods: All patients presented with symptoms of allergic rhinitis without history of bronchial asthma were included. Patients those who were clinically diagnosed with allergic rhinitis were evaluated with absolute eosinophilic count, serum IgE and Spirometric assessment. In spirometry, post bronchodilator FEV1 reversibility and post bronchodilator FEF 25–75% values were used to assess lower airway abnormalities. Results: Among 61 subjects, 32 were males and 29 were females. The maximum numbers [28] of patients were in 21–35 age group. Absolute eosinophil count was elevated in 38% of patients. 33% of patients showed elevated IgE values above 1000. 43% of patients showed FEV1 reversibility which is a sign of Bronchial hyperreactivity. 5% of patients showed impaired post bronchodilator FEF 25–75% which indicates presence of small airway disease. There was significant correlation between FEV1 reversibility and elevated IgE. Conclusion: Impaired spirometric parameters indicate coexistence of bronchial impairment and hence predisposition to progression from allergic rhinitis alone to overt asthma in future. Thus careful evaluation of lower airway has to be done to rule out coexisting subclinical asthma.
format	article
author	Devika Thayyezhuth Rajesh Venkataram Vadisha Srinivas Bhat Rajeshwary Aroor
author_facet	Devika Thayyezhuth Rajesh Venkataram Vadisha Srinivas Bhat Rajeshwary Aroor
author_sort	Devika Thayyezhuth
title	A study of Spirometric parameters in non asthmatic allergic rhinitis
title_short	A study of Spirometric parameters in non asthmatic allergic rhinitis
title_full	A study of Spirometric parameters in non asthmatic allergic rhinitis
title_fullStr	A study of Spirometric parameters in non asthmatic allergic rhinitis
title_full_unstemmed	A study of Spirometric parameters in non asthmatic allergic rhinitis
title_sort	study of spirometric parameters in non asthmatic allergic rhinitis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8ca98607975145cf8080aa1eb59850be
work_keys_str_mv	AT devikathayyezhuth astudyofspirometricparametersinnonasthmaticallergicrhinitis AT rajeshvenkataram astudyofspirometricparametersinnonasthmaticallergicrhinitis AT vadishasrinivasbhat astudyofspirometricparametersinnonasthmaticallergicrhinitis AT rajeshwaryaroor astudyofspirometricparametersinnonasthmaticallergicrhinitis AT devikathayyezhuth studyofspirometricparametersinnonasthmaticallergicrhinitis AT rajeshvenkataram studyofspirometricparametersinnonasthmaticallergicrhinitis AT vadishasrinivasbhat studyofspirometricparametersinnonasthmaticallergicrhinitis AT rajeshwaryaroor studyofspirometricparametersinnonasthmaticallergicrhinitis
_version_	1718400777037283328

A study of Spirometric parameters in non asthmatic allergic rhinitis

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