Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

A substantial obstacle in basic research is the use of poorly validated tool compounds with purported useful biological functions. Here, the authors systematically profile widely used histone acetyltransferase inhibitors and find that the majority are nonselective interference compounds.

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Autores principales:	Jayme L. Dahlin, Kathryn M. Nelson, Jessica M. Strasser, Dalia Barsyte-Lovejoy, Magdalena M. Szewczyk, Shawna Organ, Matthew Cuellar, Gurpreet Singh, Jonathan H. Shrimp, Nghi Nguyen, Jordan L. Meier, Cheryl H. Arrowsmith, Peter J. Brown, Jonathan B. Baell, Michael A. Walters
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ca9ff19d5524b75acdb413bf0ff0f30
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spelling	oai:doaj.org-article:8ca9ff19d5524b75acdb413bf0ff0f302021-12-02T17:06:30ZAssay interference and off-target liabilities of reported histone acetyltransferase inhibitors10.1038/s41467-017-01657-32041-1723https://doaj.org/article/8ca9ff19d5524b75acdb413bf0ff0f302017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01657-3https://doaj.org/toc/2041-1723A substantial obstacle in basic research is the use of poorly validated tool compounds with purported useful biological functions. Here, the authors systematically profile widely used histone acetyltransferase inhibitors and find that the majority are nonselective interference compounds.Jayme L. DahlinKathryn M. NelsonJessica M. StrasserDalia Barsyte-LovejoyMagdalena M. SzewczykShawna OrganMatthew CuellarGurpreet SinghJonathan H. ShrimpNghi NguyenJordan L. MeierCheryl H. ArrowsmithPeter J. BrownJonathan B. BaellMichael A. WaltersNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jayme L. Dahlin Kathryn M. Nelson Jessica M. Strasser Dalia Barsyte-Lovejoy Magdalena M. Szewczyk Shawna Organ Matthew Cuellar Gurpreet Singh Jonathan H. Shrimp Nghi Nguyen Jordan L. Meier Cheryl H. Arrowsmith Peter J. Brown Jonathan B. Baell Michael A. Walters Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
description	A substantial obstacle in basic research is the use of poorly validated tool compounds with purported useful biological functions. Here, the authors systematically profile widely used histone acetyltransferase inhibitors and find that the majority are nonselective interference compounds.
format	article
author	Jayme L. Dahlin Kathryn M. Nelson Jessica M. Strasser Dalia Barsyte-Lovejoy Magdalena M. Szewczyk Shawna Organ Matthew Cuellar Gurpreet Singh Jonathan H. Shrimp Nghi Nguyen Jordan L. Meier Cheryl H. Arrowsmith Peter J. Brown Jonathan B. Baell Michael A. Walters
author_facet	Jayme L. Dahlin Kathryn M. Nelson Jessica M. Strasser Dalia Barsyte-Lovejoy Magdalena M. Szewczyk Shawna Organ Matthew Cuellar Gurpreet Singh Jonathan H. Shrimp Nghi Nguyen Jordan L. Meier Cheryl H. Arrowsmith Peter J. Brown Jonathan B. Baell Michael A. Walters
author_sort	Jayme L. Dahlin
title	Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
title_short	Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
title_full	Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
title_fullStr	Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
title_full_unstemmed	Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
title_sort	assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8ca9ff19d5524b75acdb413bf0ff0f30
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Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

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