Correlation Between 25-Hydroxyvitamin D Level and Cardiac Diastolic Dysfunction in Chinese Adults with Early-Onset Type 2 Diabetes Mellitus: A Cross-Sectional Study

Lei Xiu, Xiao-ai Yao, Tao Jiang Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of ChinaCorrespondence: Tao JiangDepartment of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyilu, Yang F...

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Autores principales:	Xiu L, Yao X, Jiang T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	early-onset type 2 diabetes in adults 25-hydroxyvitamin d decreased diastolic function non-alcoholic fatty liver disease. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/8caaf738e95e4a5189cb048362b84795
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spelling	oai:doaj.org-article:8caaf738e95e4a5189cb048362b847952021-12-02T15:29:03ZCorrelation Between 25-Hydroxyvitamin D Level and Cardiac Diastolic Dysfunction in Chinese Adults with Early-Onset Type 2 Diabetes Mellitus: A Cross-Sectional Study1178-7007https://doaj.org/article/8caaf738e95e4a5189cb048362b847952021-04-01T00:00:00Zhttps://www.dovepress.com/correlation-between-25-hydroxyvitamin-d-level-and-cardiac-diastolic-dy-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Lei Xiu, Xiao-ai Yao, Tao Jiang Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of ChinaCorrespondence: Tao JiangDepartment of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyilu, Yang Fang Dian, Beijing, 100038, People’s Republic of ChinaTel/Fax +86-10-63926692Email jiangtao@bjsjth.cnPurpose: Chinese adults with early-onset type 2 diabetes mellitus have impaired diastolic function. This study aims to analyse the association between serum vitamin D levels and cardiac diastolic dysfunction in Chinese adults with early-onset type 2 diabetes mellitus.Patients and Methods: We enrolled Chinese adults with early-onset type 2 diabetes mellitus in this study. These patients were divided into two groups: those with diastolic dysfunction and those without diastolic dysfunction. We then compared the levels of serum 25-hydroxyvitamin D [25-(OH)D] between the two groups. The correlation between diastolic function and 25-(OH)D was evaluated by Pearson correlation analysis. Finally, binary logistic regression was used to analyse the relationship between the decrease in diastolic function and 25-(OH)D and other indexes in Chinese adults with early-onset type 2 diabetes mellitus.Results: The level of 25-(OH)D in patients with early-onset type 2 diabetes mellitus complicated with cardiac diastolic dysfunction was significantly lower than that in patients without cardiac diastolic dysfunction (P< 0.01). The degree of liver fibrosis in adult patients with early-onset type 2 diabetes mellitus complicated with diastolic dysfunction was significantly higher than that in adult patients without diastolic dysfunction (P< 0.01). Moreover, decreased 25-(OH)D levels were associated with decreased diastolic function in adults with early-onset type 2 diabetes.Conclusion: 25-(OH)-D was identified as an independent predictor of decreased diastolic function in adults with early-onset type 2 diabetes. The serum 25-(OH)D level in adults with early-onset type 2 diabetes was significantly reduced. 25-(OH)D influences the reduction in diastolic function in adults with early-onset type 2 diabetes and can be used as a predictor of decreased diastolic function in such patients.Keywords: early-onset type 2 diabetes in adults, 25-hydroxyvitamin D, decreased diastolic function, non-alcoholic fatty liver diseaseXiu LYao XJiang TDove Medical Pressarticleearly-onset type 2 diabetes in adults25-hydroxyvitamin ddecreased diastolic functionnon-alcoholic fatty liver disease.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1823-1831 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	early-onset type 2 diabetes in adults 25-hydroxyvitamin d decreased diastolic function non-alcoholic fatty liver disease. Specialties of internal medicine RC581-951
spellingShingle	early-onset type 2 diabetes in adults 25-hydroxyvitamin d decreased diastolic function non-alcoholic fatty liver disease. Specialties of internal medicine RC581-951 Xiu L Yao X Jiang T Correlation Between 25-Hydroxyvitamin D Level and Cardiac Diastolic Dysfunction in Chinese Adults with Early-Onset Type 2 Diabetes Mellitus: A Cross-Sectional Study
description	Lei Xiu, Xiao-ai Yao, Tao Jiang Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of ChinaCorrespondence: Tao JiangDepartment of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyilu, Yang Fang Dian, Beijing, 100038, People’s Republic of ChinaTel/Fax +86-10-63926692Email jiangtao@bjsjth.cnPurpose: Chinese adults with early-onset type 2 diabetes mellitus have impaired diastolic function. This study aims to analyse the association between serum vitamin D levels and cardiac diastolic dysfunction in Chinese adults with early-onset type 2 diabetes mellitus.Patients and Methods: We enrolled Chinese adults with early-onset type 2 diabetes mellitus in this study. These patients were divided into two groups: those with diastolic dysfunction and those without diastolic dysfunction. We then compared the levels of serum 25-hydroxyvitamin D [25-(OH)D] between the two groups. The correlation between diastolic function and 25-(OH)D was evaluated by Pearson correlation analysis. Finally, binary logistic regression was used to analyse the relationship between the decrease in diastolic function and 25-(OH)D and other indexes in Chinese adults with early-onset type 2 diabetes mellitus.Results: The level of 25-(OH)D in patients with early-onset type 2 diabetes mellitus complicated with cardiac diastolic dysfunction was significantly lower than that in patients without cardiac diastolic dysfunction (P< 0.01). The degree of liver fibrosis in adult patients with early-onset type 2 diabetes mellitus complicated with diastolic dysfunction was significantly higher than that in adult patients without diastolic dysfunction (P< 0.01). Moreover, decreased 25-(OH)D levels were associated with decreased diastolic function in adults with early-onset type 2 diabetes.Conclusion: 25-(OH)-D was identified as an independent predictor of decreased diastolic function in adults with early-onset type 2 diabetes. The serum 25-(OH)D level in adults with early-onset type 2 diabetes was significantly reduced. 25-(OH)D influences the reduction in diastolic function in adults with early-onset type 2 diabetes and can be used as a predictor of decreased diastolic function in such patients.Keywords: early-onset type 2 diabetes in adults, 25-hydroxyvitamin D, decreased diastolic function, non-alcoholic fatty liver disease
format	article
author	Xiu L Yao X Jiang T
author_facet	Xiu L Yao X Jiang T
author_sort	Xiu L
title	Correlation Between 25-Hydroxyvitamin D Level and Cardiac Diastolic Dysfunction in Chinese Adults with Early-Onset Type 2 Diabetes Mellitus: A Cross-Sectional Study
title_short	Correlation Between 25-Hydroxyvitamin D Level and Cardiac Diastolic Dysfunction in Chinese Adults with Early-Onset Type 2 Diabetes Mellitus: A Cross-Sectional Study
title_full	Correlation Between 25-Hydroxyvitamin D Level and Cardiac Diastolic Dysfunction in Chinese Adults with Early-Onset Type 2 Diabetes Mellitus: A Cross-Sectional Study
title_fullStr	Correlation Between 25-Hydroxyvitamin D Level and Cardiac Diastolic Dysfunction in Chinese Adults with Early-Onset Type 2 Diabetes Mellitus: A Cross-Sectional Study
title_full_unstemmed	Correlation Between 25-Hydroxyvitamin D Level and Cardiac Diastolic Dysfunction in Chinese Adults with Early-Onset Type 2 Diabetes Mellitus: A Cross-Sectional Study
title_sort	correlation between 25-hydroxyvitamin d level and cardiac diastolic dysfunction in chinese adults with early-onset type 2 diabetes mellitus: a cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8caaf738e95e4a5189cb048362b84795
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Correlation Between 25-Hydroxyvitamin D Level and Cardiac Diastolic Dysfunction in Chinese Adults with Early-Onset Type 2 Diabetes Mellitus: A Cross-Sectional Study

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