Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR

Repeat-associated non-ATG translation of dipeptide repeat proteins (DPRs) contributes to disease manifestation in FTD/ALS associated with the hexanucleotide repeat expansion of the C9ORF72 gene. Here the authors show that a transgenic mouse line expressing poly-PR28 in neurons displays some signs of...

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Autores principales:	Zongbing Hao, Liu Liu, Zhouteng Tao, Rui Wang, Haigang Ren, Hongyang Sun, Zixuan Lin, Zhixiong Zhang, Chenchen Mu, Jiawei Zhou, Guanghui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8cac0edff2a24ec9832f5a4a7a8a98f6
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spelling	oai:doaj.org-article:8cac0edff2a24ec9832f5a4a7a8a98f62021-12-02T15:35:49ZMotor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR10.1038/s41467-019-10956-w2041-1723https://doaj.org/article/8cac0edff2a24ec9832f5a4a7a8a98f62019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10956-whttps://doaj.org/toc/2041-1723Repeat-associated non-ATG translation of dipeptide repeat proteins (DPRs) contributes to disease manifestation in FTD/ALS associated with the hexanucleotide repeat expansion of the C9ORF72 gene. Here the authors show that a transgenic mouse line expressing poly-PR28 in neurons displays some signs of neuronal loss that mirrors that seen in the disease.Zongbing HaoLiu LiuZhouteng TaoRui WangHaigang RenHongyang SunZixuan LinZhixiong ZhangChenchen MuJiawei ZhouGuanghui WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zongbing Hao Liu Liu Zhouteng Tao Rui Wang Haigang Ren Hongyang Sun Zixuan Lin Zhixiong Zhang Chenchen Mu Jiawei Zhou Guanghui Wang Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR
description	Repeat-associated non-ATG translation of dipeptide repeat proteins (DPRs) contributes to disease manifestation in FTD/ALS associated with the hexanucleotide repeat expansion of the C9ORF72 gene. Here the authors show that a transgenic mouse line expressing poly-PR28 in neurons displays some signs of neuronal loss that mirrors that seen in the disease.
format	article
author	Zongbing Hao Liu Liu Zhouteng Tao Rui Wang Haigang Ren Hongyang Sun Zixuan Lin Zhixiong Zhang Chenchen Mu Jiawei Zhou Guanghui Wang
author_facet	Zongbing Hao Liu Liu Zhouteng Tao Rui Wang Haigang Ren Hongyang Sun Zixuan Lin Zhixiong Zhang Chenchen Mu Jiawei Zhou Guanghui Wang
author_sort	Zongbing Hao
title	Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR
title_short	Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR
title_full	Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR
title_fullStr	Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR
title_full_unstemmed	Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR
title_sort	motor dysfunction and neurodegeneration in a c9orf72 mouse line expressing poly-pr
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8cac0edff2a24ec9832f5a4a7a8a98f6
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Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR

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